Indications
Zoladex LA (generically known as goserelin) is a hormonal therapy drug used in the treatment of certain types of cancer, including prostate and breast cancer. It is also used to thin the lining of the uterus (endometrium) in preparation for certain procedures. Zoladex LA helps mimics the actions of gonadotropin-releasing hormone (GnRH or LHRH), a hormone that affects the release of sex hormones.
Goserelin is a medication that mimics the actions of gonadotropin-releasing hormone (GnRH or LHRH), a hormone that affects the release of sex hormones such as testosterone and estrogen. It works by reducing the amount of sex hormones (testosterone in men and estrogen in women) in the body.
Use and Dosage
Zoladex LA is typically given as an injection under the skin (subcutaneously) every 4 weeks or every 12 weeks, depending on the condition being treated. The injection should be given by a healthcare professional in a clinical setting.
Zoladex LA is given exactly as recommended by your doctor. If you miss an appointment to receive the medication, contact your doctor as soon as possible to reschedule your appointment.
Dosage may vary depending on the individual's medical history, condition, and response to treatment. Follow the dosing schedule recommended by your doctor and do not miss any doses. If you have any questions or concerns about how to use Zoladex LA, you should speak with your doctor or healthcare provider.
Side Effects
Common Side Effects of Zoladex LA (Goserelin):
- Acne
- Bone pain
- Breast swelling or tenderness
- Change in breast size
- Constipation
- Diarrhea
- Dizziness
- Fewer erections than usual
- Hair loss
- Mental/mood changes (such as depression mood swings hallucinations)
- Headache
- Hot flashes (flushing)
- Impotence
- Increased or decreased sexual interest
- Increased sweating
- Injection site reactions (pain bruising bleeding redness or swelling)
- Nausea
- Skin rash or itching
- Sleep problems (insomnia)
- Trouble sleeping
- Vaginal dryness/itching/discharge
Serious Side Effects of Zoladex LA (Goserelin):
- Back pain
- Blurred vision
- Bone pain
- Chest pain or pressure
- Confusion
- Constipation
- Difficulty breathing
- Drowsiness
- Dry mouth
- Dry skin
- Fruity breath odor
- Hives
- Hunger
- Increased thirst or urination
- Loss of bladder or bowel control
- Muscle pain
- Muscle weakness
- Nausea
- Pain, bruising, swelling, redness, oozing, or bleeding where the implant was injected
- Pain spreading to your jaw or shoulder
- Painful or difficult urination
- Problems with balance or coordination
- Problems with vision or balance
- Restlessness
- Severe numbness or tingling in your legs or feet
- Slurred speech and
- Sudden numbness or weakness (especially on one side of the body)
- Sudden severe headache
- Sweating
- Swelling of your face lips tongue or throat
- Tiredness
- Vomiting
- Weakness
- Weight loss
Forms and Strengths
Zoladex LA (Goserelin) is available in the following forms and strength:
Zoladex LA: Disposable Syringe
- 10.8mg
Cautions
- Keep a list of all the products you use (including prescription/nonprescription drugs and herbal supplements) and inform your doctor before starting the medication, as it may interact with other medications.
- Goserelin should be used with caution in patients with a history of diabetes or seizures, as it may worsen these conditions.
- Zoladex LA may cause a decrease in bone density, which can increase the risk of fractures.
- Goserelin may cause a reduction in sex hormones, which can lead to symptoms such as hot flashes, vaginal dryness, and decreased sex drive.
- It may cause an increase in blood sugar levels, and as a result, blood sugar should be monitored in patients with diabetes.
- Goserelin should not be used during pregnancy, as it may harm the developing fetus.
- Goserelin may cause changes in heart function, such as irregular heartbeat or QT prolongation, which can be worsened by certain medications. Therefore, it should be used with caution in patients with a history of heart disease or with certain medications that can also affect heart function.
- Zoladex may cause swelling or tenderness in the breasts, and women should inform their doctor if it occurs.
- Goserelin may increase the risk of developing certain cancers, such as breast cancer, in some patients.
- Some patients may experience mood changes or depression while taking Goserelin.
- Zoladex may interact with certain herbal supplements, such as St. John's wort, which can reduce the effectiveness of the medication.
Frequently Asked Questions (FAQ)
How is Zoladex administered?
Zoladex is typically given as an injection every 4 weeks or every 12 weeks.
Can Zoladex interact with other medications?
Yes, Zoladex may interact with other medications, inform your doctor of all the products you use before starting the medication.
Is Zoladex safe during pregnancy?
No, Zoladex should not be used during pregnancy as it may harm the developing fetus.
Resources
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/019726s059,020578s037lbl.pdf
- https://www.medicalnewstoday.com/articles/zoladex
- https://www.cancerresearchuk.org/about-cancer/treatment/drugs/goserelin-prostate-cancer
- https://www.rxlist.com/zoladex-drug.htm
- https://www.medbroadcast.com/drug/getdrug/zoladex-la
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