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Formulation: ER Tablet
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Formulation: ER Tablet
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Xigduo XR contains two active ingredients: dapagliflozin and metformin hydrochloride.
It is a prescription medication used together with diet and exercise to help improve blood sugar control in adults with type 2 diabetes.
Because it combines two diabetes medications in one tablet, Xigduo XR can lower blood sugar in more than one way.
Type 2 diabetes happens when the body does not use insulin properly or does not make enough insulin to keep blood sugar within a healthy range.
Insulin is a hormone that helps move glucose from the blood into the body’s cells, where it can be used for energy.
When insulin does not work effectively, glucose can build up in the bloodstream.
Keeping blood sugar within the target range can help reduce symptoms of diabetes and lower the risk of long-term complications.
Poorly controlled diabetes may increase the risk of problems involving the:
Xigduo XR is used as part of an overall diabetes treatment plan to help improve blood sugar control over time.
Dapagliflozin belongs to a group of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors.
Normally, the kidneys filter glucose from the blood and return much of it back into the bloodstream.
Dapagliflozin blocks some of this glucose from being reabsorbed. Instead, the extra glucose leaves the body through the urine.
This helps lower the amount of glucose in the bloodstream.
Metformin belongs to a group of medications called biguanides.
It lowers blood sugar mainly by:
Unlike medications that directly stimulate the pancreas to release more insulin, metformin mainly improves how the body manages glucose.
Dapagliflozin and metformin lower blood sugar through different mechanisms.
Dapagliflozin helps remove excess glucose through the urine, while metformin reduces glucose production by the liver and improves insulin sensitivity.
Using both medications together can provide better blood sugar control for some people than using either medication alone.
The “XR” in Xigduo XR means extended release.
The metformin portion of the tablet is designed to release gradually over time. This allows the medication to be taken on a regular schedule while providing a steady effect.
Because of this extended-release design, the tablets should be taken exactly as directed and should not usually be crushed, cut, or chewed.
Xigduo XR works best when it is used as part of a complete diabetes management plan.
Your healthcare provider may also recommend:
Xigduo XR helps manage type 2 diabetes, but it does not cure the condition.
Continue taking the medication as prescribed even if your blood sugar readings improve.
Do not stop taking Xigduo XR or change your dose without speaking with your healthcare provider.
Your healthcare provider may monitor your blood sugar, kidney function, and other health measures while you are taking Xigduo XR.
Contact your healthcare provider if your blood sugar remains consistently above or below your target range or if you develop new or unusual symptoms during treatment.
Xigduo XR comes as an extended-release tablet taken by mouth.
It is usually taken once daily in the morning with food, or exactly as directed by your healthcare provider.
Take Xigduo XR with food to help reduce stomach-related side effects from metformin, such as nausea or diarrhea.
Try to take it at about the same time each day so it is easier to remember.
Xigduo XR is an extended-release medication, which means it releases the medicine slowly over time.
Swallow the tablet whole. Do not:
Damaging the tablet may cause the medication to be released too quickly and may increase the risk of side effects.
The exact dose depends on your current diabetes treatment, kidney function, blood sugar levels, and response to therapy.
The maximum recommended daily dose is generally:
Your healthcare provider may start you on a lower dose and adjust it gradually if needed.
Your kidneys play an important role in how Xigduo XR is used safely.
If you have kidney disease or reduced kidney function, Xigduo XR may not be appropriate for you or your dose may need to be adjusted.
Your healthcare provider may check your kidney function before starting treatment and periodically while you are taking the medication.
Take Xigduo XR every day as prescribed, even if you feel well.
Type 2 diabetes may not always cause noticeable symptoms, so regular blood sugar monitoring is important to determine how well the medication is working.
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose.
If your next dose is approaching, skip the missed dose and continue with your regular schedule.
Do not take two doses at the same time or take extra medication to make up for a missed dose.
Continue checking your blood sugar as recommended by your healthcare provider.
Contact your healthcare provider if your blood sugar remains consistently too high or becomes unusually low.
Do not change your dose or stop taking Xigduo XR without speaking with your healthcare provider.
Continue following your recommended diet, exercise, and blood sugar monitoring plan while taking the medication.
Xigduo XR (Dapagliflozin/Metformin HCl) is available in the following forms and strength:
Xigduo XR contains metformin, which can rarely cause a serious condition called lactic acidosis.
Lactic acidosis happens when too much lactic acid builds up in the blood. It can be life-threatening and requires immediate medical treatment.
Seek medical attention right away if you develop symptoms such as:
The risk may be higher in people with severe kidney problems, liver problems, certain heart conditions, heavy alcohol use, or other conditions that reduce oxygen or blood flow.
Dapagliflozin can cause the body to lose extra water through the urine.
This may lead to dehydration or low blood pressure, especially in older adults, people with kidney problems, or those taking diuretics.
Contact your healthcare provider if you experience dizziness, weakness, fainting, or other signs of dehydration.
Dapagliflozin can increase the risk of genital fungal infections.
Symptoms may include itching, redness, swelling, discomfort, or unusual discharge.
Contact your healthcare provider if you develop symptoms of a genital infection.
Xigduo XR may also increase the risk of urinary tract infections.
In rare cases, these infections can become serious and spread to the kidneys or bloodstream.
Contact your healthcare provider if you develop symptoms such as painful urination, frequent urination, fever, back pain, or blood in your urine.
Xigduo XR does not usually cause significant low blood sugar when used by itself.
However, the risk of hypoglycemia may increase when it is taken with insulin or medications that increase insulin release.
Symptoms may include:
Your healthcare provider may need to adjust the dose of your other diabetes medications.
Dapagliflozin can rarely cause ketoacidosis, a serious condition in which harmful acids called ketones build up in the blood.
This can sometimes occur even when blood sugar is not extremely high.
Seek medical attention if you develop nausea, vomiting, abdominal pain, unusual tiredness, or difficulty breathing.
Kidney function is important when using Xigduo XR.
People with reduced kidney function may have a greater risk of dehydration and other complications. Xigduo XR should not be used in people with severe kidney impairment, end-stage kidney disease, or those receiving dialysis.
Your healthcare provider may check your kidney function before and during treatment.
SGLT2 inhibitors such as dapagliflozin have rarely been linked to a serious infection called Fournier’s gangrene.
Seek immediate medical attention if you develop pain, tenderness, redness, or swelling around the genital or perineal area, especially if you also have fever or feel very unwell.
Do not take Xigduo XR if you have had a serious allergic reaction to dapagliflozin, metformin, or any ingredient in the medication.
Seek emergency medical attention if you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or throat.
Long-term use of metformin can lower vitamin B12 levels in some people.
Low vitamin B12 may contribute to anemia or nerve-related symptoms.
Your healthcare provider may check your blood counts and vitamin B12 levels during long-term treatment.
Xigduo XR can interact with certain medications.
Tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, and supplements you take.
Some medications can affect kidney function, blood sugar, hydration, or the amount of metformin in your body, which may increase the risk of side effects.
Tell your healthcare provider that you take Xigduo XR before having major surgery or a procedure that requires prolonged fasting.
Xigduo XR may need to be temporarily stopped before these procedures. Current prescribing information recommends withholding it for at least 3 days before major surgery or procedures associated with prolonged fasting, when possible.
Tell your healthcare provider if you are scheduled for an imaging test that uses iodinated contrast dye.
Xigduo XR may need to be temporarily stopped before or at the time of the procedure in certain patients. Kidney function may need to be checked before restarting the medication.
Take Xigduo XR exactly as prescribed and attend any recommended blood tests or follow-up appointments.
Contact your healthcare provider if you develop severe dehydration, signs of infection, persistent vomiting, difficulty breathing, unusual weakness, or other serious symptoms while taking the medication.
Yes, but Xigduo XR may interact with certain medications. Tell your healthcare provider about all prescription drugs, over-the-counter medicines, vitamins, and supplements you take before starting treatment. Some medications may affect kidney function, blood sugar levels, hydration, or the amount of metformin in your body, which can increase the risk of side effects.
Xigduo XR is usually taken once daily in the morning with food. Try to take it at about the same time each day. Swallow the extended-release tablet whole and do not crush, cut, or chew it. Always follow the dosing instructions provided by your healthcare provider.
An increased risk of bone fractures is not considered a specific warning for Xigduo XR. However, tell your healthcare provider if you have osteoporosis, a history of fractures, or other conditions that affect your bone health. Seek medical attention if you experience unexplained or severe bone or joint pain.
No. Xigduo XR should be used together with a healthy diet and regular physical activity to help manage type 2 diabetes. Continue following the meal plan, exercise routine, blood sugar monitoring, and other lifestyle recommendations provided by your healthcare provider. Medication works best when it is used as part of an overall diabetes management plan.
| Generic name: | Dapagliflozin/Metformin Hcl |
|---|---|
| Formulation: | ER Tablet |
| Strength(s): | 5/1000mg, 10/500mg, 10/1000mg |
| Quantities Available: | 28, 56, 84, 112 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Xigduo XR (dapagliflozin/metformin hcl) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Xigduo XR is commonly prescribed in dosages of 5 mg/1000 mg, 10/500 mg, or 10 mg/1000 mg, taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
No, we do not sell dapagliflozin/metformin hcl on our website. However, you can still enjoy low prices on Xigduo XR, which contains dapagliflozin/metformin hcl as an active ingredient. To purchase Xigduo XR, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Xigduo XR (dapagliflozin/metformin hcl) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Xigduo XR (Dapagliflozin/Metformin Hcl). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Xigduo XR (Dapagliflozin/Metformin Hcl).
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