Diamicron XR (Gliclazide ER)

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Diamicron XR Brand
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Gliclazide ER (Generic alternate to Diamicron XR) Generic

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Table of contents:

Diamicron XR is a prescription medication used to treat type 2 diabetes mellitus in adults. It is usually taken once daily with breakfast or the first main meal of the day. It can be used in combination with other diabetes medications or in conjunction with diet and exercise to manage blood sugar levels.

The active ingredient in Diamicron XR is gliclazide and it is available in tablet form. Gliclazide belongs to a group of medicines called sulfonylureas and helps to lower and control blood sugar levels in the body. It works by increasing the amount of insulin released by the pancreas and helping the body use insulin more efficiently.

The modified-release formulation of the medication is designed to release the drug slowly over a 24-hour period, providing a more consistent and longer-lasting effect compared to immediate-release formulations.

Use and Dosage

Diamicron XR comes in the form of Modified Release Tablets to take them orally once a day with breakfast or with the first main meal of the day. The tablets should be swallowed whole and not chewed, crushed, or broken. Crushing or chewing the tablets may change the effectiveness of the tablet.

The dosage may vary depending on your medical condition and response to treatment, follow your doctor's instructions carefully. Monitor your blood sugar regularly and report any unusual symptoms to your doctor. Additionally, there may be certain people who should not take Diamicron XR, consult with your doctor before starting treatment.

Take your Diamicron XR at the same time each day - usually with breakfast. Taking the tablet with food can help to minimise the risk of hypoglycaemia. If is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as you remember (with food), then go back to taking your tablets as you would normally.

Side Effects

Common Side Effects of Diamicron XR (Gliclazide ER):

  • Diarrhea
  • Dizziness
  • Flatulence
  • Headache
  • Hypoglycemia (low blood sugar levels)
  • Nausea
  • Vomiting
  • Weight gain

Serious Side Effects of Diamicron XR (Gliclazide ER):

  • Changes in vision
  • Clammy skin
  • Confusion
  • Constipation
  • Depression
  • Diarrhea
  • Difficulty in breathing
  • Dizziness
  • Double vision
  • Drowsiness
  • Excessive hunger
  • Excessive sweating
  • Fatigue
  • Feeling agitated
  • Fever
  • Hallucinations
  • Indigestion
  • Loss of consciousness
  • Numbness
  • Paralysis
  • Problems in sleeping
  • Skin rash and itching
  • Slowed or faster heartbeat with chest pain
  • Slowed reactions
  • Stomach pain
  • Trembling
  • Trouble seeing or speaking
  • Unable to concentrate
  • Vomiting
  • Weakness
  • Weight loss and loss of appetite
  • Yellowing of skin and whites of the eyes

Forms and Strength

Diamicron XR (Gliclazide ER) is available in the following forms and strength:

Diamicron XR: Modified Release Tablets

  • 60mg


  • Hypoglycemia: Gliclazide can cause low blood sugar levels (hypoglycemia), especially if taken with other diabetes medications, skipping meals, or doing strenuous exercise.
  • Kidney or liver disease: Gliclazide should be used with caution in patients with kidney or liver disease, as it can affect the function of these organs and may require dose adjustments.
  • Allergic reactions: Some patients may be allergic to gliclazide or other sulfonylurea medications and may experience allergic reactions such as skin rash, itching, or swelling.
  • Pregnancy and breastfeeding: The safety of gliclazide in pregnancy and breastfeeding is not established, and it is not recommended to use it during these periods.
  • Hypersensitivity to sulfonamides: Gliclazide is a sulfonamide derivative and should not be used in patients with known hypersensitivity to sulfonamide medications.
  • Interactions with other medications: Gliclazide can interact with certain medications, including beta-blockers, anticoagulants, and corticosteroids, and may require dose adjustments or monitoring.
  • Vision changes: Rarely, gliclazide can cause changes in vision, including blurred vision or temporary loss of vision, which may be a sign of a serious condition known as non-arteritic anterior ischemic optic neuropathy (NAION).
  • Cardiovascular disease: Gliclazide has been associated with a higher risk of cardiovascular events, particularly in patients with a history of cardiovascular disease, and caution should be taken when using it in these patients.

Frequently Asked Questions (FAQ)

Can Diamicron XR (Gliclazide ER) cause weight gain?

Weight gain is not typically a side effect of Diamicron XR (Gliclazide ER). However, some people may experience weight gain due to improved blood sugar control and increased appetite.

What should I do if I miss a dose of Diamicron XR (Gliclazide ER)?

If you miss a dose of Diamicron XR (Gliclazide ER), take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not take a double dose to make up for a missed dose.

Is it safe to take Diamicron XR (Gliclazide ER) during pregnancy?

There is limited data on the safety of Diamicron XR (Gliclazide ER) during pregnancy. Talk to your doctor about the risks and benefits of taking the tablet if you are pregnant or planning to become pregnant.

Can Diamicron XR (Gliclazide ER) be taken with food?

Diamicron XR (Gliclazide ER) should be taken with food. The timing of taking the medication in relation to meals can affect its hypoglycemic action.

How long does it take for Diamicron XR (Gliclazide ER) to work?

Diamicron XR (Gliclazide ER) starts working within a few hours of taking the first dose. However, it may take several weeks to see the full effects of the medication on blood sugar levels.


It's important to purchase Diamicron XR from verified Canadian pharmacy.

Additional information

Generic name:

Gliclazide ER


Modified Release Tablets



Quantities Available:



Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Diamicron XR (Gliclazide ER). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Diamicron XR (Gliclazide ER).