Indications
Invokana (active ingredient: canagliflozin) is a prescription medication indicated for the following:
- Type 2 Diabetes Mellitus: Invokana is used to improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.
- Cardiovascular Benefits: It is also indicated to reduce the risk of major adverse cardiovascular events (including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease.
- Diabetic Nephropathy: Invokana is indicated to reduce the risk of end-stage kidney disease, doubling of serum creatinine, cardiovascular death, and hospitalization for heart failure in adults with type 2 diabetes mellitus and diabetic nephropathy with albuminuria greater than 300 mg/day.
Invokana belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, which work by helping the kidneys remove glucose from the bloodstream through urine, thereby lowering blood sugar levels and providing additional cardiovascular and renal benefits.
Uses and Dosage
Invokana comes in the form of a tablet to take by mouth as directed by your doctor, usually once daily before the first meal of the day. The dosage of Invokana is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
The recommended starting dosage for Invokana is 100mg, taken orally once daily before the first meal of the day. This dosage can be adjusted based on factors such as the patient's medical condition, response to treatment, and other medications they may be taking. However, the maximum recommended dosage for Invokana is 300mg per day for additional glycemic control. Patients should only take the dosage prescribed by their doctor and inform them of all the products they are using.
Side Effects
Common Side Effects of Invokana (Canagliflozin):
- Constipation
- Dizziness
- Dry mouth
- Fatigue
- Frequent urination
- Lightheadedness
- Nausea
- Thirst
Serious Side Effects of Invokana (Canagliflozin)
- Signs of a bladder infection (fever, burning or pain when urinating, urgent urination)
- Signs of kidney problems (change in urine output, swelling of lower extremities)
- Signs of hyperkalemia or elevated levels of potassium in the blood (muscle weakness, irregular heartbeat)
- Hypoglycemia (sudden sweating, tremors, hunger, blurred vision, tingling of hands or feet)
- Hyperglycemia (thirst, increased urination, confusion, drowsiness, fruity breath odor)
Form and Strength
Invokana (Canagliflozin) is available in the following forms and strengths:
Invokana: Tablet
- 100 mg
- 300 mg
Caution
- If you display signs and symptoms of metabolic acidosis, ketoacidosis should be assessed regardless of their blood glucose level. If ketoacidosis is suspected, INVOKANA treatment should be discontinued, and the patient should be promptly evaluated and treated.
- Consider temporarily discontinuing of INVOKANA in settings of reduced oral intake or fluid losses. If acute kidney injury occurs, discontinue and promptly treat. Monitor renal function during therapy.
- Before taking canagliflozin (INVOKANA), inform one's doctor or pharmacist if they are allergic to it, or if they have any other allergies, as the medication may contain inactive ingredients which can cause allergic reactions or other problems.
- During pregnancy, canagliflozin should be used only when clearly needed and after discussing the risks and benefits with a healthcare professional.
- There have been reports of serious, life-threatening genital infections associated with the use of the medication, including cases of pain, tenderness, erythema, or swelling in the genital or perineal area, along with fever or malaise.
- If hypersensitivity reactions occur, the use of INVOKANA should be discontinued, and the patient should be treated according to the standard of care, and monitored until signs and symptoms resolve.
- Drinking alcohol while taking INVOKANA can increase the risk of hypoglycemia (low blood sugar) and dehydration, so it is important to limit alcohol consumption while taking the medication.
- INVOKANA is not recommended for use during pregnancy, and women who are pregnant or planning to become pregnant should discuss alternative treatment options with their doctor.
Frequently Asked Questions (FAQ)
Can Invokana be taken with other diabetes medications?
Yes, INVOKANA can be taken with other diabetes medications, but you should consult a doctor before taking any new medications to avoid potential drug interactions.
Can Invokana cause dehydration?
Yes, INVOKANA can cause dehydration, and it is important to drink enough fluids while taking the medication.
Can Canagliflozin cause low blood pressure?
Yes, Canagliflozin can cause low blood pressure, and patients should be cautious when rising from a sitting or lying position to avoid dizziness or fainting.
How long does it take for Canagliflozin to start working?
Canagliflozin can lower blood sugar levels within a few days of starting the medication, but it may take up to 2-3 months to see the full effect.
Can INVOKANA help people lose weight?
It is possible that some people may experience weight loss while taking INVOKANA, but it is not a primary goal of the medication.
REVIEWS