Xeljanz (Tofacitinib)

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Xeljanz Brand
Dosage Quantity & Price
Tofacitinib (Generic alternate to Xeljanz) Generic
Dosage Quantity & Price
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Table of contents:

Xeljanz is a prescription medication used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains the active ingredient tofacitinib. Tofacitinib works by blocking the activity of enzymes called Janus kinases (JAKs) that play a role in the body's immune response. By inhibiting JAKs, tofacitinib helps to reduce inflammation and symptoms associated with autoimmune diseases.

Xeljanz is the first JAK inhibitor pill for adult patients with moderate to severe rheumatoid arthritis. It has also been approved for use in the treatment of active polyarticular course juvenile idiopathic arthritis (pcJIA) in patients 2 years of age and older.

Uses and Dosage

You should take tofacitinib as directed by your doctor. It comes in the form of a 5 mg tablet that you take by mouth once or twice daily, with or without food. Swallow the tablets whole and do not split, chew, or crush them. Take tofacitinib at around the same time(s) every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor.

The dosages of Tofacitinib may vary depending on the medical condition being treated. Here are some of the recommended dosages:

  • For Rheumatoid Arthritis and Psoriatic Arthritis: the recommended dose is 5 mg twice a day for immediate-release tablets.
  • For Ulcerative Colitis: the recommended dose is 5 mg four times a day for at least 8 weeks, followed by 5 mg or 10 mg twice a day.
  • For Polyarticular Course Juvenile Idiopathic Arthritis: the recommended dose is 5 mg twice a day.

Side Effect

Common Side Effects of Xeljanz (Tofacitinib):

Serious Side Effects of Xeljanz (Tofacitinib):

Form and Strength

Xeljanz (Tofacitinib) is available in the following forms and strength:

Xeljanz: ER Tablet

  • 5 mg
  • 10 mg

Tofacitinib: ER Tablet

  • 5 mg


  • Tofacitinib should not be used during pregnancy, as it may harm the developing fetus. It is also not known if tofacitinib is excreted in human breast milk, so it is not recommended for use while breastfeeding.
  • Xeljanz should be used with caution in patients with risk factors for serious infections.
  • Tofacitinib has a boxed warning for major adverse cardiovascular events, malignancy, and serious infections and it should be used with caution in patients with at least one heart disease risk factor.
  • Xeljanz should be used with caution in patients with a history of cancer and immune system problems. JAK inhibitors, including Xeljanz, should be used with caution in patients with certain risk factors.
  • Xeljanz may have possible side effects, and patients should be aware of the potential risks and benefits of treatment. Tofacitinib should be prescribed at the lowest effective dose necessary to achieve the desired therapeutic outcome.
  • Xeljanz may increase the risk of infections or worsen current infections. Avoid contact with individuals who have infections that may be contagious, such as chickenpox, measles, or flu. Seek medical advice if you have been exposed to an infection or for further information.
  • Tell your doctor and pharmacist if you are allergic to tofacitinib, any other medications, or any of the ingredients in tofacitinib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

Frequently Asked Questions (FAQ)

Does tofacitinib lower the immune system?

Yes, tofacitinib can lower the immune system's ability to fight infections.

Was tofacitinib approved for psoriatic arthritis?

Tofacitinib was approved by the FDA for psoriatic arthritis treatment in 2022.

Was tofacitinib approved for ulcerative colitis?

Yes, tofacitinib was approved by the FDA for ulcerative colitis treatment in 2018.

Can tofacitinib be used in combination with other medications?

Tofacitinib can be used in combination with other medications used to treat autoimmune diseases but talk to your doctor about the potential risks and benefits of combining medications.

How often is tofacitinib taken?

Tofacitinib is usually taken twice a day.


It's important to purchase Xeljanz from verified Canadian pharmacy.

Additional information

Generic name:





5mg, 10mg

Quantities Available:

56, 60, 112