Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin)

Prescription Prescription Required     Customer Reviews
Tri-Luma Cream Brand
Dosage Quantity & Price
Fluocinolone/Hydroquinone/Tretinoin (Generic alternate to Tri-Luma Cream) Generic

We don't sell this generic-version medication.

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Table of contents:

Tri-Luma cream is a prescription medication used for the short-term treatment of moderate to severe melasma (dark, patchy discoloration of the skin) on the face. It is a combination of three active ingredients that contains fluocinolone acetonide (a corticosteroid), hydroquinone (a melanin synthesis inhibitor), and tretinoin (a retinoid).

Fluocinolone acetonide works by reducing inflammation and irritation in the skin. Hydroquinone works by blocking the production of melanin, which is the pigment that gives color to the skin and can cause discoloration. Tretinoin works by increasing the rate at which skin cells turnover, helping to exfoliate the skin and create a brighter, more even tone. Together, these ingredients help to treat melasma, a skin condition characterized by dark patches on the face. While Tri-Luma Cream may improve the appearance of melasma, it is not a cure.

Uses and Dosage

Tri-Luma Cream should only be used as directed by a healthcare professional. Avoid getting the medication in your eyes, nose, or mouth. Apply Tri-Luma Cream once a day at night, at least 30 minutes before going to bed for up to 8 weeks.

To use the medication properly, follow these steps:

  1. Use a mild cleanser to wash your face and avoid using a washcloth. Rinse and pat your skin dry.
  2. Apply a pea-sized or half-inch amount of Tri-Luma Cream onto the discolored spot(s), as well as a ½ inch area of normal surrounding skin.
  3. After some time, you may find that you need to apply slightly less of the medication to achieve the desired results.
  4. Gently and evenly rub the medication into your skin until it becomes nearly invisible. Avoid applying the medication near your nose, mouth, eyes, or open wounds.

Never use more Tri-Luma Cream or apply it more often than recommended by your doctor, as this can irritate your skin and will not result in faster or better results. Do not cover the treated area with anything after applying Tri-Luma Cream.

During use of Tri-Luma Cream, skin irritation such as redness, burning, peeling, itching, or dryness may occur. If irritation persists for too long, stop using the medication immediately and contact your doctor. In some cases, Tri-Luma Cream may cause a blue-black discoloration of the skin. If this happens, discontinue use of the product, and consult with your doctor immediately.

Side effect

Common Side Effects of Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin):

  • Dry skin
  • Itchy skin
  • Skin burning
  • Skin peeling
  • Skin redness

Serious Side Effects of Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin):

  • Acne
  • Changes to the color of your skin
  • Darkening of normal skin color
  • Extra sensitive skin
  • Irritated skin
  • Rash
  • Skin irritation
  • Spider veins

Form and Strength

Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) is available in the following forms and strength:

Tri-Luma Cream: Cream

  • 0.01/4/0.05%


  • Avoid getting the cream in your eyes, nose, or mouth.
  • Tri-Luma Cream can make your skin more sensitive to sunlight, and use sun protection measures such as sunscreen or protective clothing when using Tri-Luma Cream and to avoid prolonged sun exposure.
  • Stop using the medication immediately and contact your healthcare provider if you experience severe skin irritation, rash, or other allergic reactions.
  • Tri-Luma Cream has not been studied for use in pregnant or breastfeeding women, and it should be used with caution in these populations.
  • Use Tri-Luma Cream as directed and to not use more or less than prescribed.
  • The use of Tri-Luma Cream may increase the risk of skin atrophy, which is a thinning or weakening of the skin.
  • Some individuals may experience increased hyperpigmentation instead of improvement in melasma with Tri-Luma Cream. In this case, speak with your healthcare provider about alternative treatment options.
  • Individuals with a history of allergies or skin sensitivities may have increased risk of allergic reactions to this medication.
  • The use of Tri-Luma Cream may result in skin discoloration or blisters in some individuals.
  • Tri-Luma Cream may interact with other medications or topical treatments, and it is important to disclose all medications and treatments used to your healthcare provider before starting Tri-Luma Cream.
  • The use of Tri-Luma Cream may result in an increase in acne or other skin eruptions in some individuals.
  • Tri-Luma Cream should be stored at room temperature and away from moisture and heat.

Frequently Asked Questions (FAQ)

Is Tri-Luma Cream available over the counter?

No, Tri-Luma Cream is a prescription medication and requires a prescription from a healthcare provider.

Can Tri-Luma Cream be used on areas of the body other than the face?

Tri-Luma Cream is only approved for use on the face and should not be used on other areas of the body.

How long does it take to see the results with Tri-Luma Cream?

Results with Tri-Luma Cream can vary depending on the severity of melasma and individual skin type, but some improvement may be seen in as little as 4 weeks. Full results may take up to 8 weeks.

Can I use Tri-Luma Cream with other skincare products?

Discuss the use of other skincare products with your healthcare provider before using them in conjunction with Tri-Luma Cream.

Can Tri-Luma Cream be used on all skin types?

Tri-Luma Cream is typically safe for use on most skin types but discuss any concerns with your healthcare provider before use.

Can I stop using Tri-Luma Cream once my melasma has improved?

Continue using Tri-Luma Cream as directed by your healthcare provider, even if your melasma has improved. Discontinuing use of the medication may result in a recurrence of melasma.


It's important to purchase Tri-Luma Cream from verified Canadian pharmacy.

Additional information

Generic name:






Quantities Available:

30g, 60g