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Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) Shopper Approved

Prescription Prescription Required FormationFormulation: Cream

Tri-Luma Cream

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Prescription Prescription Required FormationFormulation: Cream

Fluocinolone/Hydroquinone/Tretinoin

We don't sell this generic-version medication.

Select the quantity to see the price.

  *  
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* This price includes a dispensing fee, medical review fee, and packing fee.

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Tri-Luma Cream contains three active ingredients: fluocinolone acetonide, hydroquinone, and tretinoin. It is a prescription cream used for the short-term treatment of moderate to severe melasma on the face.

Melasma

Melasma is a skin condition that causes brown or gray-brown patches, most often on the cheeks, forehead, upper lip, nose, or chin.

It can be triggered or worsened by factors such as:

  • Sun exposure
  • Hormonal changes
  • Pregnancy
  • Certain medications

Tri-Luma helps lighten these dark patches and improve the overall appearance of the skin.

How Tri-Luma Works

Tri-Luma combines three medications that work in different ways.

Fluocinolone acetonide is a mild topical corticosteroid. It helps reduce inflammation and irritation.

Hydroquinone is a skin-lightening agent. It reduces the production of melanin, the pigment that gives skin its color.

Tretinoin is a retinoid. It increases skin-cell turnover and helps remove pigmented surface cells more quickly.

Why the Combination Is Helpful

Using all three ingredients together helps target melasma in several ways at once.

Tri-Luma can:

  • Reduce excess pigmentation
  • Increase skin-cell turnover
  • Reduce inflammation
  • Help dark patches gradually become lighter

Short-Term Treatment

Tri-Luma is intended for short-term use, not continuous long-term treatment.

Your healthcare provider will determine how long you should use it based on how your skin responds.

Melasma can return after treatment is stopped, especially if the skin is exposed to sunlight.

Sun Protection Is Important

Sun exposure can make melasma worse and can reduce the benefit of treatment.

Use a broad-spectrum sunscreen, wear protective clothing, and limit unnecessary sun exposure while using Tri-Luma.

Sun protection is an important part of both treating melasma and helping prevent it from returning.

Apply Tri-Luma Cream once daily in the evening, at least 30 minutes before bedtime.

Use it exactly as directed by your healthcare provider. Tri-Luma is intended for short-term treatment of melasma on the face.

Before Applying Tri-Luma

Gently wash your face and neck with a mild cleanser.

Rinse well and pat your skin dry.

Avoid harsh soaps, abrasive cleansers, or scrubbing the skin with a washcloth, as these may increase irritation.

How Much to Apply

Apply a thin layer of Tri-Luma to the areas affected by melasma.

Extend the cream slightly beyond each dark patch to cover about ½ inch of normal-looking skin around the area.

Gently rub the cream into the skin until it is evenly distributed.

Areas to Avoid

Do not apply Tri-Luma:

  • Near the eyes
  • Around the corners of the nose
  • Around the mouth
  • On open wounds
  • Inside the nose or mouth

Tri-Luma is for use on the skin only.

Do Not Cover the Treated Skin

Do not cover treated areas with a bandage or airtight dressing after applying Tri-Luma.

You may use moisturizers and cosmetics during the day if they do not irritate your skin.

Wash Your Hands After Applying It

Wash your hands after applying Tri-Luma unless your hands are the area being treated.

This helps prevent the cream from accidentally getting into your eyes, nose, or mouth.

Sun Protection Is Essential

Sun exposure can make melasma worse and reduce the benefit of treatment.

During the day, use a broad-spectrum sunscreen with SPF 30 or higher, wear protective clothing, and limit exposure to direct sunlight, tanning beds, and sunlamps.

How Long to Use Tri-Luma

Tri-Luma is intended for short-term treatment.

Clinical studies commonly evaluated treatment for up to 8 weeks, but your healthcare provider will decide how long you should continue using it.

Treatment should be stopped when your melasma is adequately controlled.

Skin Irritation

Mild to moderate irritation can occur during treatment.

You may notice:

  • Redness
  • Peeling
  • Mild burning
  • Dryness
  • Itching

These reactions can occur as your skin adjusts to the medication.

If irritation becomes severe, persistent, or unusually painful, stop using Tri-Luma and contact your healthcare provider.

Blue-Black Skin Discoloration

Hydroquinone can rarely cause a blue-black darkening of the skin called exogenous ochronosis.

Stop using Tri-Luma and contact your healthcare provider if you notice unusual blue-black discoloration.

What to Do If You Miss a Dose

If you miss an application, skip it and apply Tri-Luma at your next regularly scheduled time.

Do not apply extra cream or use it more often to make up for a missed dose.

Follow Your Healthcare Provider’s Instructions

Do not use more Tri-Luma or apply it more often than prescribed.

Using extra cream will not make melasma improve faster and may increase redness, peeling, burning, and other skin irritation.

Common Side Effects of Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin):

  • Dry skin
  • Itchy skin
  • Skin burning
  • Skin peeling
  • Skin redness

Serious Side Effects of Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin):

  • Acne
  • Changes to the color of your skin
  • Darkening of normal skin color
  • Extra sensitive skin
  • Irritated skin
  • Rash
  • Skin irritation
  • Spider veins

Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) is available in the following forms and strength:

Tri-Luma Cream: Cream

  • 0.01/4/0.05%

 Avoid the Eyes, Nose, and Mouth

Tri-Luma Cream is for use on the skin only.

Do not apply it:

  • In or around the eyes
  • Inside the nose
  • Inside the mouth
  • On other mucous membranes
  • On open or broken skin

If the cream accidentally gets into your eyes, rinse them thoroughly with water.

Sun Sensitivity

Tri-Luma can make your skin more sensitive to sunlight.

During treatment, use a broad-spectrum sunscreen with SPF 30 or higher, wear protective clothing, and limit unnecessary sun exposure.

Avoid tanning beds and sunlamps.

Sun exposure can also make melasma worse and reduce the benefit of treatment.

Skin Irritation

Redness, peeling, burning, dryness, itching, and acne are common during treatment.

Mild irritation may occur as your skin adjusts to the medication.

Stop using Tri-Luma and contact your healthcare provider if you develop severe or persistent irritation, blistering, significant swelling, or another serious skin reaction.

Blue-Black Skin Discoloration

The hydroquinone in Tri-Luma can rarely cause exogenous ochronosis, a condition that causes gradual blue-black darkening of the skin.

Stop using Tri-Luma and contact your healthcare provider if you notice unusual blue-black discoloration.

Skin Thinning

Tri-Luma contains fluocinolone, a topical corticosteroid.

Using corticosteroids for too long can lead to skin thinning, visible small blood vessels, or other changes in the skin.

Use Tri-Luma only for the length of time prescribed.

Hormonal Effects From the Corticosteroid

If enough fluocinolone is absorbed through the skin, it can rarely affect the body’s natural production of corticosteroid hormones.

This risk is more likely with prolonged use or excessive application.

Do not use larger amounts or apply Tri-Luma more often than prescribed.

Allergic Reactions

Do not use Tri-Luma if you are allergic to any of its ingredients.

The cream also contains sodium metabisulfite, which can cause serious allergic reactions in people who are sensitive to sulfites.

Seek immediate medical attention if you develop:

  • Hives
  • Severe rash
  • Swelling of the face, lips, tongue, or throat
  • Wheezing or difficulty breathing

Stop using Tri-Luma if a serious allergic reaction occurs.

Pregnancy

Tell your healthcare provider if you are pregnant or planning to become pregnant.

Tri-Luma contains tretinoin, which may harm a developing baby.

Because of this potential risk, Tri-Luma should only be considered during pregnancy when a healthcare provider determines that the potential benefit justifies the risk.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or planning to breastfeed.

It is not known whether enough fluocinolone, hydroquinone, or tretinoin is absorbed through the skin to pass into breast milk.

Avoid applying Tri-Luma to areas where an infant could come into direct contact with the medication.

Worsening Pigmentation

Some people may notice worsening or unusual changes in skin pigmentation instead of improvement.

Contact your healthcare provider if your melasma becomes darker or your skin develops an unexpected color change.

Acne and Other Skin Eruptions

Tri-Luma may cause or worsen acne in some people.

Other skin reactions may include dryness, peeling, redness, burning, itching, or irritation.

Tell your healthcare provider if these effects become severe or persistent.

Other Skin Products and Medications

Tri-Luma may cause more irritation when used with other topical products.

Tell your healthcare provider about all:

  • Prescription skin medications
  • Over-the-counter creams
  • Retinoids
  • Acne products
  • Exfoliating products
  • Cosmetics
  • Skin-lightening treatments

Do not add another strong topical treatment without first checking with your healthcare provider.

Use Only as Prescribed

Apply only a thin layer once daily, at least 30 minutes before bedtime.

Do not apply extra cream or use it more often in an attempt to make melasma improve faster.

Tri-Luma is intended for short-term treatment, not continuous long-term use.

Storage

Store Tri-Luma Cream as directed on the product label, away from excessive heat.

Keep the tube tightly closed and out of the reach of children and pets.

Is Tri-Luma Cream available over the counter?

No. Tri-Luma Cream is a prescription medication and requires a prescription from a healthcare provider.

Can Tri-Luma Cream be used on areas other than the face?

Tri-Luma Cream is approved for the short-term treatment of melasma on the face. Do not use it on other areas of the body unless your healthcare provider specifically tells you to.

How long does it take to see results with Tri-Luma Cream?

Some people may begin to notice improvement within about 4 weeks. More noticeable improvement may take up to 8 weeks, depending on the severity of the melasma and how your skin responds to treatment. Use Tri-Luma exactly as prescribed and continue sun protection throughout treatment.

Can I use Tri-Luma Cream with other skincare products?

Possibly, but some skincare products may increase irritation while you are using Tri-Luma. Tell your healthcare provider about all the products you use, especially retinoids, acne treatments, exfoliating acids, skin-lightening products, harsh cleansers, and scrubs. Gentle moisturizers and sunscreen are often recommended, but your healthcare provider can help you choose products that are less likely to irritate your skin.

Can Tri-Luma Cream be used on all skin types?

Tri-Luma may be used in people with different skin types, but the response and risk of irritation or pigment changes can vary. Some people may be more likely to develop dryness, irritation, darker pigmentation, or other skin changes. Your healthcare provider can determine whether Tri-Luma is appropriate for your skin type and condition.

Can I stop using Tri-Luma Cream once my melasma improves?

Tri-Luma is intended for short-term treatment and should not be used continuously as a long-term maintenance cream. Your healthcare provider may tell you to stop once your melasma is adequately controlled. Melasma can return after treatment ends, especially with sun exposure, so daily sun protection remains important. If the dark patches return, speak with your healthcare provider before restarting Tri-Luma.

REVIEWS

Additional Information Book
Generic name:

Fluocinolone/Hydroquinone/Tretinoin

Formulation:

Cream

Strength(s):

0.01/4/0.05%

Quantities Available:

15g, 30g

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Tri-Luma Cream can I order at once from a Canadian pharmacy?

When ordering Tri-Luma Cream (fluocinolone/hydroquinone/tretinoin) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Tri-Luma Cream is usually applied once daily in the evening to the affected areas. The quantity needed for a 90-day supply will depend on the size of the tube prescribed and your specific treatment plan.

Do you sell fluocinolone/hydroquinone/tretinoin?

No, we do not sell fluocinolone/hydroquinone/tretinoin directly, but you can still enjoy low prices on Tri-Luma Cream, which contains fluocinolone/hydroquinone/tretinoin as active ingredients. You will need a valid prescription from your healthcare provider to purchase Tri-Luma Cream. We require this to dispense the medication safely and appropriately. You can mail, fax, or upload your prescription through your online account.

Do you offer shipping of Tri-Luma Cream (fluocinolone/hydroquinone/tretinoin) to the United States?

Yes, we ship Tri-Luma Cream (fluocinolone/hydroquinone/tretinoin) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin).