Indications
Synvisc (generically known as Hylan GF 20) is a medication used to treat knee pain in patients with joint inflammation caused by osteoarthritis. It is a viscosupplement injection made from a natural substance that lubricates and cushions the joint and can provide up to six months of relief from knee pain.
Synvisc is indicated for use in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. It is usually given after other arthritis medications have been tried without success. Synvisc-One is a specific formulation of Synvisc that is designed to be injected in a single dose instead of multiple injections.
Uses and Dosage
Synvisc (Hylan GF 20) is administered by injection directly into the affected joint usually once a week, without using skin disinfectants containing ammonium salts to prepare the injection site. If excess fluid is present in the joint, a doctor may remove it before administering the injection.
Dosage is dependent on the individual medical condition and response to treatment. To avoid increased side effects, the injection should not be given into a vein or artery. Patients should also avoid any strenuous activities that put pressure on the knee joint for at least 48 hours after receiving the injection, such as jogging, tennis, heavy lifting or standing for more than an hour.
After the injection, initial pain and swelling in the knee joint is normal, and if it continues or worsens, patients should consult their doctor immediately. Follow the injection schedule as it may take up to three injections before the full benefits of Synvisc occur.
Side Effects
Common Side Effects of Synvisc (Hylan GF 20):
- Fever, chills, nausea
- Headache, dizziness
- Itching or skin irritation around the knee
- Muscle pain, trouble walking
- Prickly feeling in your skin
- Warmth, redness, pain, stiffness, swelling, or puffiness where the medicine was injected
Serious Side Effects of Synvisc (Hylan GF 20):
- Difficulty breathing
- Closing of the throat
- Swelling of the lips, tongue, or face; or hives
Form and Strength
Synvisc (Hylan GF 20) is available in the following forms and strengths:
Synvisc: Injection Kit
- 16mg/syr
Caution
- Allergic reaction: Patients may experience an allergic reaction to the hylan G-F 20, which is the active ingredient in Synvisc.
- Infection risk: As with any injection or medical procedure, there is a risk of infection at the injection site.
- Bleeding disorders: Synvisc should be used with caution in patients with bleeding disorders or those taking blood-thinning medications.
- Joint infections or skin diseases: Patients with existing joint infections, skin diseases, or infections near the injection site should use Synvisc with caution.
- Pregnancy and breast-feeding: There is limited information about the safety of Synvisc in pregnant and breastfeeding women, so caution is advised when considering this treatment.
- Existing knee replacements or prostheses: Synvisc should not be used in patients with knee replacements or other knee prostheses.
- Rare but serious adverse events: There have been rare reports of serious adverse events associated with the use of Synvisc, including neurologic problems, cardiovascular events, and infection.
- Interactions with other medications: Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking before starting treatment with Synvisc.
- Duration of relief: While Synvisc can provide long-lasting relief from knee pain, it is not a permanent solution, and repeat injections may be needed for continued relief.
Frequently Asked Questions (FAQ)
How often can Synvisc injections be administered?
Synvisc injections are usually given as a series of three injections, given one week apart. Additional injections may be given as needed, but typically no more than two series of injections are recommended.
Is Synvisc a steroid?
No, Synvisc is not a steroid. It is a viscosupplement injection made from a natural substance that lubricates and cushions the joint.
How long does it take for Synvisc to start working?
Patients may start to feel relief from knee pain within a few days of the first injection, but it typically takes several weeks for the full effects of Synvisc to be felt.
Are there any restrictions on activity after receiving a Synvisc injection?
Patients should avoid any strenuous activity, such as running or jumping, for at least 48 hours after receiving a Synvisc injection. After that, patients can slowly return to their regular activities.
Can Synvisc be used in other joints besides the knee?
Synvisc is only approved for use in the knee joint, and it should not be used in other joints.
Can Synvisc be used in patients with severe osteoarthritis?
Synvisc may not be as effective in patients with severe osteoarthritis, and it may be less likely to provide long-lasting relief in these patients.
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