Arthrotec (Diclofenac/Misoprostal)

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Arthrotec Brand
Dosage Quantity & Price
Diclofenac/Misoprostal (Generic alternate to Arthrotec) Generic

We don't sell this generic-version medication.

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Table of contents:

Arthrotec is a prescription medication used to treat the symptoms of osteoarthritis and rheumatoid arthritis. It is a combination of two drugs, diclofenac, and misoprostol. Diclofenac being a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and relieve pain, while misoprostol is used to protect the stomach from diclofenac's adverse effects. The combination of these two drugs used to treat arthritis in people at elevated risk of getting stomach/intestinal ulcers and complications from the ulcers.

Arthrotec is typically used in adult patients who are at an elevated risk of developing stomach ulcers or bleeding with NSAID therapy. It should not be used in women of childbearing potential unless the patient requires NSAID therapy and is at an elevated risk of developing stomach ulcers or bleeding and should only be used under medical supervision.

Uses and Dosage

To take Arthrotec, swallow the tablets whole with a full glass of water (8 ounces/240 milliliters), unless otherwise instructed by your doctor. After taking the medication, do not lie down for at least 10 minutes to help prevent stomach upset. Avoid crushing, chewing, or dissolving the tablets, as this can increase the risk of side effects. Additionally, take Arthrotec with food to further reduce the risk of stomach issues and diarrhea.

To ensure the safe and effective use of Arthrotec, take it on a regular schedule as directed by your doctor. Following a consistent dosing schedule can help you avoid missing any doses. Do not make any changes to your dosing or the duration of treatment without discussing it with your doctor. Even if you begin to feel better, continue taking Arthrotec as prescribed and do not stop taking it abruptly without first consulting your doctor.

Based on the search results, the recommended dosages of Arthrotec vary depending on the medical conditions being treated, the patient's response to treatment, and any other medications being taken. Here are some dosage recommendations from the search results:

  • For rheumatoid arthritis: Arthrotec 50, 100, or 150 four times a day or three times a day, or Arthrotec 75 two times a day.
  • For osteoarthritis: Arthrotec 50 given three times a day, or Arthrotec 50 or 75 given two times a day.

Side effect

Common Side Effects of Arthrotec (Diclofenac/Misoprostal):

  • Bloating
  • Dizziness
  • Drowsiness
  • Gas
  • Headache
  • Heartburn
  • Nausea

Serious Side Effects of Arthrotec (Diclofenac/Misoprostal):

  • Changes in urine output
  • Dehydration
  • Easy bruising or bleeding
  • High blood pressure or hypertension
  • Irregular periods
  • Painful swallowing
  • Palpitations
  • Ringing in the ears
  • Seizures
  • Severe diarrhea
  • Signs of liver disease (severe abdominal pain, dark urine, yellowish eyes and skin, persistent vomiting)
  • Symptoms of heart failure (shortness of breath, unusual tiredness, sudden weight gain, swelling of the lower extremities)
  • Unexplained stiff neck

Form and Strength

Arthrotec (Diclofenac/Misoprostal) is available in the following forms and strength:

Arthrotec: Tablet

  • 50mg/200mcg
  • 75mg/200mcg


  • Arthrotec should not be used during pregnancy or while breastfeeding, as it may harm the fetus or newborn.
  • Arthrotec is not typically recommended for use in children, as its safety and effectiveness have not been studied in this population.
  • Arthrotec may cause drowsiness or dizziness in some individuals, especially when taken at higher doses or for longer periods of time. Avoid driving or operating heavy machinery while taking Arthrotec until you know how it affects you.
  • Individuals with a history of stomach ulcers or bleeding should use Arthrotec with caution, as it may increase the risk of these conditions.
  • Arthrotec should be used with caution in individuals with liver or kidney problems, a history of heart disease or high blood pressure, or a history of blood disorders.
  • Arthrotec should not be used by pregnant women, as it may cause harm to the fetus, and should be used with caution in breastfeeding women.
  • Arthrotec may interact with several other medications, including blood thinners, corticosteroids, and certain antidepressants or anti-anxiety drugs, which may increase the risk of serious side effects or reduce the effectiveness of the medication.
  • Individuals should inform their healthcare provider of all the medications they are taking before starting Arthrotec and should avoid taking over-the-counter pain relievers with Arthrotec without consulting their doctor.

Frequently Asked Questions (FAQ)

How long does Arthrotec take to work?

Arthrotec may begin to work within a few hours of taking it, but it may take up to several weeks to achieve maximum benefit in relieving symptoms.

Can Arthrotec be taken with food?

Arthrotec should be taken with food or milk to help prevent stomach upset.

What should I do if I miss a dose of Arthrotec?

If you miss a dose of Arthrotec, take it as soon as possible. However, if it is closer to the time for your next dose, skip the missed dose and resume your regular dosing schedule.

How should Arthrotec be stored?

Arthrotec should be stored at room temperature, away from moisture and heat. The tablet should be kept out of reach of children.

Can Arthrotec be used in individuals with a history of stomach ulcers or bleeding?

Arthrotec should be used with caution and under medical supervision in individuals with a history of stomach ulcers or bleeding, as it may increase the risk of these conditions.


It's important to purchase Arthrotec from verified Canadian pharmacy.

Additional information

Generic name:





50mg/200mcg, 75mg/200mcg

Quantities Available:

60, 180