Savaysa (generically known as edoxaban) is an anticoagulant medication used to lower the risk of stroke and blood clots in people with nonvalvular atrial fibrillation or deep vein thrombosis/pulmonary embolism. Savaysa belongs to a class of medications known as direct oral anticoagulants, which target specific clotting factors in the blood. It works by blocking certain clotting proteins in the blood, specifically the enzyme complex called factor Xa.
Unlike warfarin, another common anticoagulant, Savaysa does not require routine blood tests to monitor its effectiveness. Your doctor should check your kidney function before you start taking Savaysa.
Uses and Dosage
Savaysa is typically taken once per day by mouth in tablet form, with or without food as directed by your doctor. The dosage will depend on your medical condition, weight, response to treatment, and other medications you may be taking. It is important to inform your doctor and pharmacist about all products you use, including prescription drugs, nonprescription drugs, and herbal products.
If you have difficulty swallowing the tablet whole, you can crush the tablet and mix it with 2 to 3 ounces (60 to 90 milliliters) of water or applesauce and consume the entire mixture immediately. Avoid preparing this mixture for future use.
The standard dose of Savaysa (edoxaban) for most patients is 60 mg taken orally once daily with or without food, following 5 to 10 days of treatment with a parenteral anticoagulant. However, the dosage may be adjusted based on factors such as medical condition, response to treatment, weight, and other medications being taken. For patients with moderate renal dysfunction (creatinine clearance 15 to 50 mL/min) or low body weight (60 kg or less), a reduced dose of 30 mg daily may be recommended.
Follow the instructions and guidelines given by your doctor and pharmacist when taking Savaysa, and do not hesitate to ask any questions or express any concerns you may have about the medication.
Common Side Effects of Savaysa (Edoxaban Tosilate):
- Any bleeding
- Easy bruising
- Low red blood cells
- Changes in liver tests
Serious Side Effects of Savaysa (Edoxaban Tosilate):
- Excessive blood loss
- Severe headache
- Unusual Weakness
- Unable to control bowel and bladder
- Tingling sensation (legs or back after spinal puncture or tap)
Form and Strength
Savaysa (Edoxaban Tosilate) is available in the following forms and strength:
- 30 mg
- 60 mg
- Like other anticoagulants, Savaysa can increase the risk of bleeding, including serious and potentially fatal bleeding. It is important to tell your doctor if you have a history of bleeding disorders or if you are taking other medications that increase the risk of bleeding, such as aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
- The use of Savaysa can increase the risk of thrombotic events (blood clots). Your doctor will need to take into consideration your individual risk factors for these events before prescribing Savaysa.
- Although moderate alcohol consumption is generally considered safe while taking Savaysa, excessive alcohol intake can increase the risk of bleeding and should be avoided.
- Savaysa is primarily eliminated by the kidneys, so it should be used with caution in people who have moderate to severe kidney impairment. Your doctor will need to adjust your dose of Savaysa depending on your kidney function.
- Savaysa should be used with caution in people with moderate to severe liver impairment, as the drug’s efficacy and safety have not been studied in this population.
- Elderly patients may be more susceptible to the effects of Savaysa, including bleeding and thrombotic events.
- Savaysa should be used with caution in patients who are undergoing surgery or other invasive procedures, as it may increase the risk of bleeding. Your doctor may need to temporarily stop Savaysa prior to the procedure.
- Savaysa can interact with other medications, including prescription and over-the-counter medications, as well as vitamins and herbal supplements. It is important to tell your doctor about all medications and supplements you are taking before starting Savaysa.
- The safety of Savaysa during pregnancy and breastfeeding is not known, and it should be used with caution in women who are pregnant or breastfeeding.
- Some people may experience allergic reactions to Savaysa or its components. Symptoms can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. Seek medical attention immediately if you experience any of these symptoms.
- Regular monitoring of kidney function, liver function, and blood clotting factors may be necessary while taking Savaysa.
Frequently Asked Questions (FAQ)
Is Savaysa safe during pregnancy and breastfeeding?
The safety of Savaysa during pregnancy and breastfeeding is not known, and it should be used with caution in women who are pregnant or breastfeeding.
How long do I need to take Savaysa?
The duration of Savaysa treatment will depend on your individual medical history and the reason you are taking it. Your doctor will advise you on how long you need to take Savaysa.
What should I do if I miss a dose of Savaysa?
If you miss a dose of Savaysa, take it as soon as you remember, and then continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
How quickly does it take for Savaysa to work?
The effects of this pill depend on how your body tolerates the medication. Typically, it works within a couple of hours to thin your blood and prevent clots from forming.