Persantine (Dipyridamole)

Indications

Persantine (generically known as Dipyridamole) is an antiplatelet drug that helps prevent blood clots in people with certain heart or blood vessel disorders, such as coronary artery disease. Dipyridamole is an antiplatelet drug. It works by preventing platelets from clumping together, which in turn helps to keep blood flowing and blood vessels open.

Dipyridamole is sometimes used in combination with other drugs, such as aspirin, to further reduce the risk of blood clots. It can also be used in cardiac nuclear stress tests as a stress agent to assess the function of the heart. It helps to keep blood flowing by stopping platelets from clumping together and by keeping heart blood vessels open.

Uses and Dosage

Persantine (Dipyridamole) is a medication that comes in the form of a tablet to be taken orally usually 4 times a day. Take the tablet before meals at the same time each day. However, to lessen stomach upset, your healthcare provider may advise taking the medicine with food or milk. Swallow the tablet whole with a drink of water and do not crush or chew it. To ensure the effectiveness of the medication. Take Persantine exactly as prescribed by your healthcare provider.

The recommended dosage of Persantine (Dipyridamole) can vary depending on the medical condition being treated and may differ from person to person. The usual recommended dose of Persantine for the treatment of prophylaxis of thromboembolism after cardiac valve replacement is 75-100 mg taken orally 4 times daily as an adjunct to the usual warfarin therapy. However, the dose may be adjusted according to body weight.

Side effect

Common Side Effects of Persantine (Dipyridamole):

• Abnormal liver function tests
• Diarrhea
• Dizziness
• Headache
• Mild skin rash or itching
• Muscle or joint pain
• Rash
• Redness
• Tingly feeling under your skin
• Upset stomach
• Vomiting
• Warmth

Serious Side Effects of Persantine (Dipyridamole):

• Black, bloody, or tarry stools
• Chest pain
• Clay-colored stools
• Coughing up blood
• Dark urine
• Difficulty breathing
• Hives
• Itching
• Lightheadedness
• Loss of appetite
• Nausea
• Nosebleeds or other bleeding
• Swelling of your face, lips, tongue, or throat
• Tiredness
• Upper stomach pain
• Vomit that looks like coffee grounds
• Yellowing of the skin or eyes (jaundice)

Form and Strength

Persantine (Dipyridamole) is available in the following forms and strength:

Dipyridamole: Tablet

• 50 mg
• 75 mg
• 100 mg

Caution

• People who are allergic to dipyridamole should avoid taking Persantine.
• Dipyridamole can increase the risk of bleeding in people who have bleeding disorders or are taking medications that affect blood clotting.
• People with liver or kidney disease may need to take a lower dose of Persantine or be monitored closely while taking the medication.
• Persantine can lower blood pressure, which may be a concern for people who already have low blood pressure or are taking medications that lower blood pressure.
• Dipyridamole can cause chest pain in some people with heart disease, so it should be used with caution in these patients.
• The safety of Persantine during pregnancy and breastfeeding is not known, so it should only be used if the benefits outweigh the potential risks.
• Persantine can increase the risk of bleeding during and after surgery, so you should inform your doctor and dentist that you are taking Persantine before any surgery or dental procedure.
• Dipyridamole may cause bronchospasm in people with asthma or other lung diseases, so it should be used with caution in these patients.
• Persantine can cause changes in blood pressure, so it should be used with caution in people with high or low blood pressure.
• Persantine can cause dizziness or drowsiness in some people, so it is important to use caution when driving or operating machinery until you know how the medication affects you.

Frequently Asked Questions (FAQ)

When is the best time to take dipyridamole?

Take it before meals at the same time each day. Swallow the tablet whole with a drink of water.

Why take dipyridamole before food?

Take this medicine with a full glass of water at least half to 1 hour before food for better absorption. It may be taken with meals if gastrointestinal irritation occurs.

What are the possible drug interactions of Persantine?

Persantine can interact with several medications, including blood thinners such as warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), and some heart medications.

Resources

• https://www.rxlist.com/persantine-drug.htm
• https://flcard.com/office-services/adenosine-persantine-nuclear-stress-test/
• https://www.goodrx.com/dipyridamole/what-is
• https://www.webmd.com/drugs/2/drug-6977/persantine-oral/details
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/012836s061lbl.pdf