Indications
Heparin Preservative Free is an anticoagulant (blood thinner) used to treat and prevent blood clots, pulmonary embolism, peripheral arterial embolism, clotting disorders, and to prevent clotting during surgery. It works in the same way as standard heparin, as an anticoagulant or blood thinner. It prevents blood clots from forming by inhibiting the formation of fibrin, a protein that is essential for blood clotting.
The preservative-free formulation is used in certain populations, such as neonates and infants, who may be sensitive to benzyl alcohol, which is commonly used as a preservative in medical products. The preservative-free formulation is also used in patients who are allergic or intolerant to benzyl alcohol.
Use and Dosage
Heparin Preservative Free should be given by intermittent intravenous injection. The vial should be used only once, and any unused portion should be discarded. Confirm the correct vial choice prior to administration of the drug. Additionally, preservative-free Heparin Sodium Injection should be used to reduce the risk of toxicity from benzyl alcohol. Consult with a healthcare provider for specific instructions on how to use Heparin Preservative Free vial.
To use Heparin Sodium Injection Preservative Free vial, first ensure that you have the correct vial for your intended use. Then, clean the injection site with an alcohol swab and insert the needle into the vial. Draw up the prescribed dose of Heparin Sodium Injection and remove any air bubbles from the syringe. Finally, administer the injection as instructed by your healthcare provider. Follow proper injection techniques and dispose of used needles and syringes in a sharps container to prevent unintentional needle-stick injuries. Remember to always consult with your healthcare provider for specific instructions on how to use any medication.
Side Effects
Common Side Effects of Heparin Preservative Free (Heparin Sodium, Porcine):
- Allergic reactions (fever, chills, hives, difficulty breathing, runny nose, watery eyes, headache, nausea, and vomiting)
- Injection site reactions (mild pain, redness, or irritation)
- Itching and burning of the feet
Serious Side Effects of Heparin Preservative Free (Heparin Sodium, Porcine):
- Blurred vision
- Confusion
- Eye pain or swelling, or seeing halos around lights
- Fast, irregular, or pounding heartbeats
- Feeling unsteady
- Fluttering in your chest; shortness of breath
- High fever, profuse sweating, or tremors
- Lightheartedness, or passing out
- Loss of coordination
- Severe headache
- Slurred speech, arm or leg weakness, or trouble walking
- Sudden dizziness
- Sudden vision loss
- Tunnel vision
- Very stiff muscles
Forms and Strength
Heparin Preservative Free (Heparin Sodium, Porcine) is available in the following forms and strength:
Heparin Preservative Free: Vial
- 1000 iu/mL
Cautions
- Extreme caution should be used when administering to infants and neonates.
- Heparin sodium should not be used in patients with severe thrombocytopenia or an uncontrollable active bleeding state.
- The preservative Benzyl alcohol can cause adverse reactions in certain populations, such as neonates, infants, and individuals who are sensitive or allergic to benzyl alcohol.
- Before administering heparin, the healthcare provider should perform a baseline platelet count and monitor the patient's platelet count regularly during treatment.
- Patients with a history of heparin-induced thrombocytopenia (HIT) or heparin-induced thrombosis with thrombosis (HITT) should not receive heparin unless necessary and after consulting with a specialist.
- Patients who are allergic or intolerant to heparin should not receive heparin preservative free.
- Healthcare providers should use extreme caution when administering heparin preservative free to patients with pre-existing bleeding disorders or conditions that increase the risk of bleeding.
- Heparin preservative free should be stored and handled with care, as exposure to heat or light can reduce its efficacy.
- Pregnant women should only receive heparin preservative free if the benefits outweigh the risks, as heparin can cross the placenta and potentially harm the developing fetus.
- Patients with liver or kidney disease may require adjusted dosing or increased monitoring while receiving heparin preservative free.
Frequently Asked Questions (FAQ)
How is Heparin Preservative Free administered?
Heparin Preservative Free is typically administered intravenously (IV) or subcutaneously (under the skin) by a healthcare provider. The dosage and frequency may vary depending on the patient's condition and other factors.
Is there any special storage or handling required for Heparin Preservative Free?
Yes, Heparin Preservative Free should be stored at room temperature away from light and heat. It should not be frozen or shaken. Additionally, healthcare providers should follow proper procedures for handling and disposing of unused portions of the medication.
Can pregnant women receive Heparin Preservative Free?
Pregnant women should only receive Heparin Preservative Free if the potential benefits outweigh the potential risks. Heparin can cross the placenta and potentially harm the developing fetus.
Resources
- https://www.healthline.com/health/drugs/heparin-injectable-solution
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/017037Orig1s183lbl.pdf
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017037s158lbl.pdf
- https://www.rxlist.com/heparin-preservative-free-drug.htm
- https://www.pfizerhospitalus.com/products/heparin-sodium-injection
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