Lovenox is an injectable drug used to help reduce the risk of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE). Lovenox contains an active ingriedent called enoxaparin sodium. Enoxaparin belongs to a class of drugs known as low molecular weight heparin (LMWH). It works by binding to antithrombin III, which enhances the inhibition of certain blood clotting factors (such as Factor Xa). This helps to prevent the formation of blood clots.
Lovenox can be indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism in patients undergoing abdominal surgery, knee replacement surgery, medical patients at risk for thromboembolic complications due to severely restricted mobility during acute illness, and in patients undergoing hip replacement surgery during and following hospitalization.
Uses and Dosage
Lovenox comes as prefilled syringe usually administered by injection under the skin (subcutaneously) or intravenously in a hospital setting. It should not be injected into the muscle. The drug is usually taken twice a day, and treatment typically lasts for 10 to 14 days.
Use enoxaparin exactly as directed and do not inject more or less of it, or more often than prescribed by your doctor. Enoxaparin is usually started in the hospital and continued at home. Carefully follow the directions on your prescription label and ask your doctor or pharmacist if you have any questions or concerns.
The recommended dosage of Enoxaparin depends on the condition being treated and other factors such as the patient’s weight, age, and kidney function. The recommended dosage for prevention of deep venous thrombosis (DVT) is typically 40 mg once a day given as a subcutaneous injection. For prevention of blood clots after surgery, the recommended dosage is typically 30 mg twice daily or 40 mg once daily given as a subcutaneous injection. The exact dosage and duration of treatment should be determined by a healthcare professional based on the individual patient’s needs and circumstances.
Common Side Effects of Lovenox (Enoxaparin Sodium):
- Redness or irritation at the injection site
Serious Side Effects of Lovenox (Enoxaparin Sodium):
- Abnormal vaginal bleeding
- Bleeding gums
- Blood in your urine or stools
- Cold hands and feet
- Coughing up blood or vomit that looks like coffee grounds
- Easy bruising
- Pale skin
- Problems with speech or vision
- Purple or red spots under your skin
- Shortness of breath
- Sudden severe headache
- Sudden weakness (especially on one side of the body)
- Unusual bleeding
- Unusual tiredness
Form and Strength
Lovenox (Enoxaparin Sodium) is available in the following forms and strengths:
Lovenox: Prefilled Syringe
- Patients who are at risk of bleeding, such as those with a history of bleeding disorders, should use caution while taking Enoxaparin.
- Enoxaparin can increase the risk of bleeding, which can be fatal, and should therefore be used with caution in patients who are at an increased risk of bleeding, such as those with uncontrolled high blood pressure or a low platelet count.
- If you have certain medical conditions, including eye problems caused by diabetes or a stomach ulcer, should let your doctor know before taking Enoxaparin.
- Caution while taking Enoxaparin if you have received heparin and have developed low blood platelets should also use it.
- There is also a risk of spinal or epidural hematomas for patients who are anticoagulated with low molecular weight heparins (LMWH) or Enoxaparin, which is why this medication carries a boxed warning and special precautions. Carefully follow dosing instructions and seek urgent medical attention if there are any signs of bleeding or blood clots during treatment.
Frequently Asked Questions (FAQ)
How should Enoxaparin be stored?
Enoxaparin should be stored at room temperature, away from light and moisture. It should not be frozen, and any unused portions should be discarded appropriately.
Can Enoxaparin be used during pregnancy?
Enoxaparin may be used during pregnancy if the potential benefits outweigh the potential risks to the fetus. However, this should be discussed with a healthcare provider.
How long does it take for Enoxaparin to start working?
Enoxaparin starts working quickly, within a few hours of administration. However, it may take several days of treatment for the full effect to be seen.
Can Enoxaparin be taken with food?
Yes, Enoxaparin can be taken with or without food as directed by a healthcare professional.
Are there any drug interactions with Enoxaparin?
Yes, Enoxaparin may interact with other medications such as non-steroidal anti-inflammatory drugs (NSAIDs), antiplatelet drugs like aspirin, and certain antibiotics.