Indications
Mirtazapine, also known by its brand name Remeron, is an antidepressant medication used to treat major depressive disorders. It belongs to a class of drugs called tetracyclic antidepressants. Tetracyclic antidepressants work by affecting the balance of certain natural chemicals in the brain.
Mirtazapine can be used to treat other conditions such as obsessive-compulsive disorder and anxiety disorders. It is also sometimes prescribed off-label for insomnia, anxiety, post-traumatic stress disorder (PTSD), and attention-deficit hyperactivity disorder (ADHD). Mirtazapine works by blocking certain receptors in the brain to help increase serotonin levels.
Uses and Dosage
Mirtazapine should be taken orally as a tablet, either with or without food, as prescribed by your doctor. The dosage of Mirtazapine is determined by the individual's medical condition and response to the medication. It is important to take this medication regularly, at the same time each day, to achieve the desired effects. It may take between one to four weeks to observe an improvement in symptoms. Do not increase the dose or take it more often than prescribed.
For the treatment of major depressive disorder, the recommended starting dose of Mirtazapine (mirtazapine) Tablets is 15 mg/day, administered as a single dose in the evening prior to sleep. Studies have shown that the effective dose range is 15 to 45 mg/day. Patients who do not respond to the initial 15-mg dose may benefit from dose increases up to a maximum of 45 mg/day. Due to the long elimination half-life of REMERON, which is approximately 20 to 40 hours, dose changes should not be made at intervals of less than 1 to 2 weeks to allow sufficient time to accurately evaluate the therapeutic response to the given dose.
Side Effects
The most common side effects of Remeron include:
- Constipation
- Dizziness
- Drowsiness
- Dry mouth
- Increased appetite
- Strange dreams
- Weight gain
Form and Strength
Remeron and its generic alternative Mirtazapine are available in the following form and strengths:
Remeron: Tablet
- 30 mg
Mirtazapine: Tablet
- 15 mg
- 30 mg
- 45 mg
Caution
- Patients should avoid taking mirtazapine in conjunction with a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvo), methylene blue injection, phenelzine (Nardil), selegiline (Eldepry), or tranylcypromine (Parnate) for two weeks before and after taking mirtazapine. Doing so could lead to adverse effects and should be avoided.
- Patients taking mirtazapine should be monitored closely for agitation, irritability, abnormal behaviors, suicidal thoughts or tendencies, and increased depression, particularly in teenagers and young adults. If any of these symptoms become apparent, medical attention should be sought immediately.
- Patients taking mirtazapine should be aware that it can temporarily lower the number of white blood cells in their blood, increasing the risk of infection. To reduce the risk of infection, patients should take measures to avoid contact with people who have infections.
- Patients should not suddenly stop taking mirtazapine without first consulting their doctor. The doctor may suggest gradually reducing the dosage before completely discontinuing the medication, to prevent a possible worsening of the condition and to reduce the risk of withdrawal symptoms such as headache, nausea, or general discomfort or illness.
- Patients taking mirtazapine should be aware that it may cause drowsiness, impair their thinking, or affect their ability to control body movements. Before driving, operating machinery, or undertaking any activity which requires alertness and coordination, patients should ensure that they are aware of how they may be affected by the medication.
Frequently Asked Questions (FAQ)
How long does it take for Remeron (Mirtazapine) to start working?
It may take up to 4 weeks for Remeron (Mirtazapine) to start working and to achieve full benefits.
How does Remeron (Mirtazapine) work?
Remeron (Mirtazapine) works by affecting certain chemicals in the brain called neurotransmitters. It increases the amount of serotonin and norepinephrine in the brain, which helps to improve mood and relieve symptoms of depression.
Is Remeron (Mirtazapine) safe?
Yes, Remeron (Mirtazapine) is generally safe when taken as prescribed. However, it is important to discuss possible side effects and drug interactions with your doctor before taking this medication.
What should I do if I miss a dose of Remeron (Mirtazapine)?
If you miss a dose of Remeron (Mirtazapine), take it as soon as you remember, unless it is close to the time for your next dose. In that case, skip the missed dose and take your next dose at the scheduled time. Do not take two doses at once to make up for a missed one.
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