Premarin (Conjugated Estrogen)

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Premarin Brand
Dosage Quantity & Price
Conjugated Estrogen (Generic alternate to Premarin) Generic

We don't sell this generic-version medication.

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Premarin, also known as conjugated estrogens, is a medication commonly prescribed to treat menopause symptoms and other hormone-related conditions. It is a prescription medication that contains a mixture of conjugated estrogens, which are a type of female sex hormone. It is often used to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and painful intercourse.

Premarin is a commonly used hormone replacement therapy (HRT) drug prescribed to women in menopause. It is made of conjugated estrogens in treating menopausal symptoms such as hot flashes, night sweats, and vaginal dryness.

Uses and Dosage

Premarin is available in tablet form, which can be taken by mouth with or without food as prescribed by a healthcare provider. If you experience stomach upset, taking the medication with food or immediately after a meal may help. Do not chew, crush, or dissolve the tablets, swallow the tablets whole as doing so may increase the risk of side effects. The dosage and treatment duration will be determined based on factors such as your medical condition and response to treatment. Follow the instructions provided by your healthcare provider while taking Premarin.

The recommended dosages of Premarin depend on the condition being treated. Here are the typical starting doses for different conditions:

  • Menopausal symptoms: The typical starting dose is 0.3 mg by mouth once a day.
  • Low estrogen: The starting dose is determined by your provider based on the condition causing low estrogen. The starting dose ranges from 0.3 mg to 1.25 mg by mouth once a day for 3 weeks, with 1 week off (no tablets taken during this week). Then this cycle is repeated.
  • Breast cancer: The typical dose is 10 mg by mouth 3 times a day for at least 3 months.
  • Prostate cancer: The typical dose is 1.25 mg to 2.5 mg by mouth 3 times a day.
  • Prevention of bone loss (osteoporosis): The typical starting dose is 0.3 mg by mouth once a day.

Side Effects

Common Side Effects of Premarin (Conjugated Estrogen):

  • Nausea
  • Headache
  • Dizziness
  • Vomiting
  • Bloating
  • Stomach upset
  • Breast tenderness
  • Tiredness
  • Weight changes

Serious Side Effects of Premarin (Conjugated Estrogen)

  • Unusual vaginal bleeding
  • Breast lumps
  • Increased vaginal irritation and discharge
  • Mental or mood changes
  • Severe abdominal pain
  • Persistent vomiting
  • Yellowish skin
  • Swelling of the extremities
  • Dark urine
  • Signs of deep vein thrombosis or pulmonary embolism (chest pain, severe headache, unusual sweating, difficulty breathing, sudden dizziness, fainting)

Form and Strength

Premarin (Conjugated Estrogen) is available in the following forms and strengths:

Premarin: Tablet

  • 0.3mg
  • 0.45mg
  • 0.625mg
  • 0.9mg
  • 1.25mg


  • Using Premarin, an estrogen-only medication, may increase your chance of developing uterine cancer. Tell any unusual vaginal bleeding immediately, as this can be a warning sign of cancer of the uterus. Make sure to have your healthcare provider check any abnormal vaginal bleeding to identify the cause.
  • Premarin has the potential to cause dark and blotchy areas on the skin and face, known as melasma. It can be worsened by exposure to sunlight, so limit sun exposure, avoid tanning booths and sunlamps, and wear protective clothing when outdoors, including the use of sunscreen.
  • Estrogen combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.
  • Avoid using estrogens, both with or without progestins, to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).
  • Do not use estrogens, whether with or without progestins, to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function). This is because using estrogen alone may increase your chances of getting strokes or blood clots, while using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer or blood clots.

Frequently Asked Questions (FAQ)

Is this medication safe?

Premarin is proven safe. Even so, you must consult your physician if you encounter severe and unusual adverse effects because this medication could increase the risk of endometrial cancer and uterine cancer.

How long does this medication take to work?

It could take about a month before you notice an improvement in your menopausal symptoms.

When is the best time to take this medication?

Postmenopausal women could take this medication any time of the day provided that it is the same time of the day, each day.


It's important to purchase Premarin from verified Canadian pharmacy.

Additional information

Generic name:

Conjugated Estrogen




0.3mg, 0.9mg, 0.45mg, 0.625mg, 1.25mg

Quantities Available:

28, 56, 84, 100


Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Premarin (Conjugated Estrogen). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Premarin (Conjugated Estrogen).