Nytol Extra Strength (Diphenhydramine - non Rx)

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Nytol Extra Strength Brand
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Diphenhydramine - non Rx (Generic alternate to Nytol Extra Strength) Generic

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Table of contents:

Nytol Extra Strength is a sleep aid used for the relief of occasional nighttime sleeplessness. Nytol Extra Strength can help individuals who are having trouble sleeping to fall asleep faster and stay asleep longer. It can also cause drowsiness, which is why it is used as a sleep aid medication.

Nytol Extra Strength contains the active ingredient diphenhydramine, which is an antihistamine. Diphenhydramine works by blocking the action of histamine, which is a substance in the body that is involved in producing allergic reactions such as sneezing, itching, and runny nose.

Use and Dosage

Nytol Extra Strength is available in the form of a caplet, which is a type of tablet that is shaped like a capsule. The caplets are designed to be taken orally, either with or without food, depending on the preference of the individual. Take Nytol Extra Strength Caplets orally, with a full glass of water. The caplet should be swallowed whole, without crushing or chewing it.

To use Nytol Extra Strength Caplets, the recommended dosage as per the manufacturer's instructions is to take 1 caplet (50mg) at bedtime, if needed or as directed by a doctor. Take the medication 20-30 minutes before going to bed with water. In case of drowsiness in the morning, reduce the dose to 0.5 caplets. The medication should not be taken in larger amounts than prescribed by the doctor. If the symptoms persist after a few days of use, consult a doctor. Additionally, read the label carefully before use and follow the instructions as directed.

The recommended dosage for Nytol Extra Strength is 1 caplet (50mg) taken at bedtime, if needed or as directed by a doctor. The medication should be taken orally with water, 20-30 minutes before going to bed. If drowsiness occurs in the morning, the dose can be reduced to 0.5 caplets. Do not take more than the recommended dosage. Note that Nytol Extra Strength Caplets should not be used in children under 12 years of age.

Side Effects

Common Side Effects of Nytol Extra Strength (Diphenhydramine - non-Rx):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth, nose, and throat
  • Headache
  • Inability to concentrate
  • Increased perspiration
  • Nausea or vomiting
  • Restlessness
  • Upset stomach

Serious Side Effects of Nytol Extra Strength (Diphenhydramine - non-Rx):

  • Chest tightness
  • Decreased muscle coordination
  • Difficulty in passing urine
  • Excitation (especially in children)
  • Insomnia
  • Muscle weakness
  • Nervousness
  • Rapid heart rate
  • Skin rash or hives
  • Vision problems
  • Wheezing
  • Signs of an allergic reaction, like:
    • Rash
    • Hives
    • Itching
    • Red, swollen, blistered, or peeling skin with or without fever
    • Wheezing
    • Tightness in the chest or throat
    • Trouble breathing, swallowing, or talking
    • Unusual hoarseness
    • Swelling of the mouth, face, lips, tongue, or throat

Forms and Strength

Nytol Extra Strength (Diphenhydramine - non-Rx) is available in the following forms and strength:

Nytol Extra Strength: Caplet

  • 50mg


  • Nytol Extra Strength (Diphenhydramine) is a drowsy (sedating) antihistamine and is more likely to make you feel sleepy than other antihistamines.
  • Diphenhydramine should be used with caution in the elderly, who are more likely to experience side effects.
  • Diphenhydramine can cause problems in some predisposed patients, including those with renal impairment or allergies to the medication.
  • Alcohol may increase drowsiness and dizziness while taking diphenhydramine.
  • Do not give the medication to a child younger than 2 years old. It is always advisable to consult a healthcare professional before taking any medication, to understand the potential risks and benefits and to ensure it is safe for you to use.
  • Diphenhydramine can cause dizziness, blurred vision, and confusion, which can affect your ability to drive or operate machinery, so avoid these activities until you know how the caplets affect you.
  • Diphenhydramine should be used with caution in individuals with glaucoma, an enlarged prostate, asthma, chronic obstructive pulmonary disease (COPD), or thyroid disease.
  • Diphenhydramine may cause urinary retention, especially in men with an enlarged prostate, and may worsen symptoms of urinary retention.
  • Diphenhydramine may interact with other medications, including other sedating medications, antidepressants, and medications used to treat allergies or motion sickness.

Frequently Asked Questions (FAQ)

What is Nytol Extra Strength?

Nytol Extra Strength is a type of Nytol product that contains a higher dose of diphenhydramine than the regular strength formula.

How does Nytol work? Diphenhydramine is an antihistamine that can cause drowsiness, so it is used as a sleep aid.

Is Nytol Extra Strength safe to use?

Nytol Extra Strength (Diphenhydramine) can cause side effects and interact with other medications, consult a healthcare professional before taking the caplets.

How should Nytol Extra Strength be taken?

Follow the instructions on the package or as directed by a healthcare professional. Do not exceed the recommended dose.

Can Nytol Extra Strength interact with other medications?

Yes, diphenhydramine can interact with other medications, check with a healthcare professional before taking Nytol Extra Strength with other medications.


It's important to purchase Nytol Extra Strength from verified Canadian pharmacy.

Additional information

Generic name:

Diphenhydramine – non Rx





Quantities Available:



Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Nytol Extra Strength (Diphenhydramine - non Rx). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Nytol Extra Strength (Diphenhydramine - non Rx).