Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx)

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Benadryl Itch Spray Brand
Dosage Quantity & Price
Diphenhydramine Hcl/Zinc Acetate - non Rx (Generic alternate to Benadryl Itch Spray) Generic

We don't sell this generic-version medication.

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Table of contents:

Benadryl Itch Spray is an over-the-counter topical medication that can be used to provide relief from skin irritation and itching. This itch relief spray provides fast, effective relief from pain and itching associated with insect bites, minor burns, sunburn, minor skin irritations, minor cuts, scrapes, and rashes due to poison ivy, oak, and sumac.

Benadryl Itch Spray contains 2% diphenhydramine HCl as a topical analgesic and 0.1% zinc acetate as a skin protectant. Diphenhydramine belongs to a class of drugs known as antihistamines. It works by blocking the effects of a certain natural substance (histamine) that causes itching. Zinc Acetate helps relieve symptoms such as dry skin, weeping, or oozing.

Use and Dosages

Use Benadryl Itch Spray only on the skin as directed by your doctor. If you are self-treating, follow all directions on the product package. Apply to the affected area as directed, usually no more than 3 to 4 times a day.

  1. Clean the affected area with soap and water, then gently pat dry.
  2. Shake the can well before use.
  3. Apply the spray to the affected area as directed by your doctor or the product package label.
  4. Wash your hands immediately after use unless the area being treated includes the hands.
  5. Use the spray no more than 3 to 4 times a day, unless directed otherwise by your doctor.

Do not use it on large areas of the body or more often than directed, as this may increase the risk of side effects. Avoid getting the spray in your eyes, nose, ears, or mouth. If it gets in any of these areas, wipe it off and rinse with water.

Stop using the spray and consult your doctor if your condition worsens, if symptoms do not improve within 7 days or last after 7 days of treatment, or if symptoms clear up and return in a few days. If you suspect you have a serious medical problem, seek medical help immediately.

Side Effects

Common Side Effects of Benadryl Itch Spray (Diphenhydramine HCl/Zinc Acetate non-Rx):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth, nose, and throat
  • Increased chest congestion
  • Loss of appetite
  • Nausea
  • Skin irritation
  • Vomiting

Serious Side Effects of Benadryl Itch Spray (Diphenhydramine HCl/Zinc Acetate non-Rx):

  • Allergic reactions-skin rash, itching, hives
  • Burning, crusting, or peeling of dry skin
  • Difficulty walking, difficulty urinating
  • Enlarged pupils in the eyes
  • Face flushing
  • Mental/mood changes (such as hallucinations, unusual excitement, confusion)
  • Severe dizziness
  • Swelling of the face, lips, tongue, or throat
  • Trouble breathing

Forms and Strength

Benadryl Itch Spray (Diphenhydramine HCl/Zinc Acetate non-Rx) is available in the following forms and strength:

Benadryl Itch Spray: Spray

  • 2%/0.1%


  • Some individuals may be allergic to diphenhydramine or zinc acetate, the active ingredients in Benadryl Itch Spray. Signs of an allergic reaction may include rash, itching, swelling, dizziness, and trouble breathing. If you experience any of these symptoms, discontinue use of the medication and seek medical attention right away.
  • Benadryl Itch Spray should not be used on large areas of skin or for extended periods of time. Doing so may increase the risk of side effects.
  • Benadryl Itch Spray may interact with other medications you are taking. Be sure to tell your doctor or pharmacist if you are taking any other medications, including prescription medications, over-the-counter medications, or herbal supplements.
  • Benadryl Itch Spray should not be sprayed near the eyes or mouth. If accidental exposure occurs, rinse with water right away.
  • It is not known if Benadryl Itch Spray is safe to use during pregnancy or while breastfeeding. Consult with a healthcare professional before use if you are pregnant or breastfeeding.
  • Benadryl Itch Spray is generally not recommended for use in children under 2 years old unless directed by a healthcare professional.
  • The active ingredient in Benadryl Itch Spray, diphenhydramine, can increase sensitivity to sunlight. It is recommended to avoid sun exposure and to use sunscreen when using this product.
  • Benadryl Itch Spray should not be used on broken or infected skin, as it may increase the risk of side effects and further irritation.
  • Overusing Benadryl Itch Spray may lead to skin irritation, redness, and other adverse effects. Use the product as directed and avoid excessive use.
  • Individuals with certain medical conditions, such as glaucoma, prostate problems, and thyroid disease, should use Benadryl Itch Spray with caution and only under the guidance of a healthcare professional.

Frequently Asked Questions (FAQ)

Can Benadryl Itch Spray be used on children?

Benadryl Itch Spray can be used on children two years of age and older. However, it is always a good idea to consult with a healthcare provider before using any medication on a child.

How should Benadryl Itch Spray be stored?

Benadryl Itch Spray should be stored at room temperature (between 68-77°F) and kept out of reach of children. Avoid storing the spray in direct sunlight or in a humid environment.

How long can I use Benadryl Itch Spray for?

Benadryl Itch Spray should only be used for a brief period of time (no more than seven days) unless directed by a healthcare provider. If symptoms persist after seven days, stop use and consult with a healthcare provider.



It's important to purchase Benadryl Itch Spray from verified Canadian pharmacy.

Additional information

Generic name:

Diphenhydramine Hcl/Zinc Acetate – non Rx





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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Benadryl Itch Spray (Diphenhydramine Hcl/Zinc Acetate - non Rx).