Maxzide (Triamterene/Hctz) Shopper Approved

Prescription Prescription Required FormationFormulation: Tablet


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Prescription Prescription Required FormationFormulation: Tablet


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Maxzide is a medication that is a combination of two diuretics or "water pills" called triamterene and hydrochlorothiazide. It is used to treat high blood pressure and edema (swelling caused by excess fluid in the body). Maxzide works by helping the kidneys eliminate water and salt from the body, which reduces blood volume and as a result, decreases blood pressure.

Maxzide helps people who have developed or are at risk for having low potassium levels on hydrochlorothiazide. It works by causing you to make more urine, which helps your body get rid of extra salt and water, reducing extra fluid in the body caused by conditions such as heart failure, liver disease, or kidney disease. By doing so, it can help to lessen symptoms such as shortness of breath or swelling in your ankles or feet.

Uses and Dosage

Maxzide is available in a tablet form of triamterene and hydrochlorothiazide 75mg/50 mg (Maxzide). It is a tablet medication that should be taken by mouth as directed by your doctor, usually once daily in the morning with or without food.

Avoid taking the tablet within 4 hours of your bedtime to prevent having to get up to urinate. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 4 hours before or at least 4 to 6 hours after these medications.

The dosage of Maxzide is based on your medical condition and response to treatment. Use the tablet regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well.

Side Effect

Common Side Effects of Maxzide (Triamterene/Hctz):

  • Blurred vision
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Eye pain
  • Headache
  • Lightheadedness
  • Nausea
  • Upset stomach
  • Vomiting
  • Weakness

Serious Side Effects of Maxzide (Triamterene/Hctz):

  • Blurred vision
  • Burning eyes
  • Chest pain
  • Constipation
  • Dark urine
  • Difficulty breathing
  • Fast, slow, or uneven heart rate
  • Fever
  • Flu-like symptoms
  • Fluttering in your chest
  • Hives
  • Increased thirst
  • Increased urination
  • Leg cramp
  • Limp feeling
  • Little or no urination
  • Loss of appetite
  • Loss of movement
  • Muscle or joint pain
  • Muscle weakness
  • Numbness or tingling
  • Rash or patchy skin color that worsens in sunlight
  • Red or purple skin rash with blistering and peeling
  • Restlessness
  • Swelling of your face, lips, tongue, or throat
  • Thirst
  • Tingly feeling
  • Tunnel vision
  • Upper stomach pain
  • Yellowing of the skin or eyes (jaundice)

Form and Strength

Maxzide (Triamterene/Hctz) is available in the following forms and strength:

Triamterene/Hctz: Tablet

  • 75/50mg


  • Patients with kidney disease should use Maxzide with caution, as it can increase the risk of certain electrolyte imbalances and kidney damage.
  • Maxzide can also increase the risk of hyperkalemia (elevated levels of potassium in the blood), especially in patients with kidney disease or who are taking other medications that can increase potassium levels.
  • Maxzide can interact with other medications, such as nonsteroidal anti-inflammatory drugs and ACE (Angiotensin Converting Enzyme) inhibitors, which can increase the risk of kidney damage and electrolyte imbalances.
  • Maxzide can cause dehydration due to excessive water loss, so patients should be monitored for signs of dehydration, such as dizziness, dry mouth, or dark urine.
  • Maxzide can cause low blood pressure (hypotension), especially in patients who are dehydrated, elderly, or taking other medications that can lower blood pressure.
  • Maxzide may cause dizziness or lightheadedness, especially during the first few days of treatment or when standing up from a sitting or lying position. Patients should avoid driving or operating heavy machinery until they know how Maxzide affects them.
  • Maxzide may cause an increase in blood sugar levels, so patients with diabetes should monitor their blood sugar levels closely while taking Maxzide.
  • Maxzide may interact with certain foods or supplements that contain potassium or salt, such as potassium-rich fruits, salt substitutes, or over-the-counter medications.
  • Maxzide is not recommended for use in pregnant or breastfeeding women, as it may harm the developing fetus or newborn.
  • Maxzide may cause side effects such as stomach upset, headache, or fatigue. Patients should report any persistent or worrisome side effects to their healthcare provider.

Frequently Asked Questions (FAQ)

Can Maxzide be used during pregnancy?

Maxzide should not be used during pregnancy unless the potential benefits outweigh the risks. Talk to your healthcare provider if you are pregnant or planning to become pregnant before taking Maxzide.

Can Maxzide be used in children?

Maxzide is not recommended for use in children under the age of 18. Talk to your healthcare provider about appropriate treatment options for pediatric patients with high blood pressure or edema.

How should Maxzide be stored?

Maxzide should be stored at room temperature, away from heat and moisture. Keep Maxzide out of the reach of children.

Can Maxzide be taken with food?

Yes, Maxzide can be taken with food to help reduce stomach upset. It is important to take Maxzide with food or immediately after eating.


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Maxzide (Triamterene/Hctz). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Maxzide (Triamterene/Hctz).