Indications
Mandelamine is a medication used to prevent and treat urinary tract infections. It contains methenamine, which stops the growth of bacteria in the urine, and an ingredient that helps to make the urine more acidic.
Methenamine is in a class of drugs called urinary antiseptics, and it works by releasing formaldehyde in the urine, which kills bacteria. It is often prescribed to people who perform self-catheterization or to patients who have a catheter. It is available in tablet form and is taken by mouth.
Use and Dosage
Mandelamine is available in the form of a tablet that is taken orally, according to your doctor's instructions. The dosage of the medicine depends on your medical condition, and response to treatment. The amount of medicine prescribed for children is also based on their age and weight.
Methenamine is more effective when your urine is acidic, so your doctor may test the acidity of your urine and recommend measures to increase its acidity, such as taking vitamin C, drinking cranberry juice, avoiding foods that decrease acidity, and adjusting alkalinizing medications.
To ensure optimal benefits, take Mandelamine at even intervals. To help you remember, take the medication at the same time(s) every day.
Continue taking Mandelamine for the entire time prescribed, even if you begin to feel better. Avoid skipping doses or stopping the medication prematurely, as this may promote bacterial growth and lead to the return of the infection. Taking more of the drug than directed may increase your risk of side effects.
Side Effects
Common Side Effects of Mandelamine (Methenamine Mandelate):
- Nausea
- Upset stomach
- Painful urination
- Rash
Serious Side Effects of Mandelamine (Methenamine Mandelate):
- Blood in urine
- Lower back pain
- Pain or burning while urinating
- Skin rash
Forms and Strength
Mandelamine (Methenamine Mandelate) is available in the following forms and strength:
Mandelamine: Tablet
- 500 mg
Cautions
- Long-term use of Mandelamine may increase the risk of developing crystals in the urine, which can lead to bladder irritation or stone formation. Drinking plenty of water and maintaining normal urine flow can help prevent these problems.
- Mandelamine can cause an allergic reaction in some people. Signs of an allergic reaction may include difficulty breathing, hives, or swelling of the face, lips, tongue, or throat. Seek medical attention immediately if you experience any of these symptoms.
- Mandelamine is not recommended for use in children under 6 years of age.
- Mandelamine is not recommended for use in pregnant women unless the benefits outweigh the risks. It is not known if Mandelamine passes into breast milk.
- Mandelamine may cause dizziness or drowsiness. Patients should avoid driving or operating heavy machinery until they know how they react to the medication.
- Mandelamine may cause false-positive results on certain laboratory tests for glucose in the urine. Inform your healthcare provider that you are taking this medication if you are undergoing any urine tests.
- Mandelamine may cause interactions with certain herbal supplements and vitamins. Inform your healthcare provider about any supplements you are taking before starting treatment with Mandelamine.
- Mandelamine may cause the urine to turn blue or green in color. This is a harmless side effect and will go away once you stop taking the medication.
- Mandelamine may decrease the effectiveness of certain medications, such as sulfa antibiotics, by making the urine less acidic. Inform your healthcare provider about all medications you are taking before starting treatment with Mandelamine.
- Mandelamine may interact with other medications, including some antibiotics and antacids. Inform your healthcare provider about all medications you are taking before starting treatment with Mandelamine.
- Mandelamine should be taken with food to minimize stomach upset and nausea.
- Mandelamine should be used with caution in patients with a history of bladder obstruction, urinary tract blockage, or prostate enlargement. These conditions can increase the risk of developing bladder problems while taking Mandelamine.
- Mandelamine should be used with caution in patients with liver or kidney problems. Dosage adjustments may be necessary for these patients.
Frequently Asked Questions (FAQ)
What should I do if I miss a dose of Mandelamine?
If you miss a dose of Mandelamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
Can Mandelamine be crushed or cut?
Mandelamine tablets should not be crushed or cut as this can affect the release of the active ingredient.
How long Mandelamine should be taken?
The duration of treatment with Mandelamine will depend on the severity of the infection and your healthcare provider's instructions. Complete the full course of treatment even if you start to feel better.
Can Mandelamine be used to treat other types of infections?
Mandelamine is only approved for the prevention and treatment of urinary tract infections. It is not recommended for use in other types of infections.
Can Mandelamine cause a false positive on a drug test?
Mandelamine is not known to cause false positives on a drug test.
Resources
- https://www.webmd.com/drugs/2/drug-5658/mandelamine-oral/details
- https://www.drugs.com/cons/mandelamine.html
- https://www.goodrx.com/methenamine-hippurate/what-is
- https://www.mayoclinic.org/drugs-supplements/methenamine-oral-route/precautions/drg-20064676?p=1
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