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Lotriderm Cream (clotrimazole and betamethasone dipropionate) is a prescription topical medication used to treat certain fungal skin infections that cause redness, itching, swelling, and irritation.

It contains two active ingredients that work together to treat the infection and relieve uncomfortable skin symptoms.

  • Clotrimazole: An antifungal medication that helps eliminate fungi responsible for skin infections.
  • Betamethasone Dipropionate: A potent topical corticosteroid that helps reduce inflammation, itching, redness, and swelling.

Lotriderm Cream belongs to a class of medications called combination antifungal and corticosteroid treatments.

The antifungal ingredient targets the infection, while the corticosteroid reduces the inflammatory response caused by the infection.

Lotriderm is commonly prescribed for inflamed fungal skin infections such as athlete’s foot, jock itch, and ringworm.

However, because the medication contains a potent corticosteroid, it is not necessarily the first choice for every fungal skin infection. Antifungal-only treatments may be more appropriate in many situations.

Lotriderm should only be used for fungal skin infections when a healthcare provider determines that the combination of an antifungal and corticosteroid is appropriate.

Treatment of Athlete’s Foot (Tinea Pedis)

Lotriderm Cream may be prescribed to treat certain cases of athlete’s foot, medically known as tinea pedis.

Athlete’s foot is a fungal infection that commonly affects the skin between the toes and the soles of the feet.

It develops when fungi grow in warm, moist environments, such as sweaty socks, tight shoes, or shared changing rooms.

The infection is usually caused by dermatophytes, a group of fungi that grow on keratin, a protein found in the outer layers of the skin.

Common symptoms include itching, burning, redness, peeling skin, and cracking between the toes.

Some people may also experience dry, scaly patches on the soles or sides of their feet.

Lotriderm Cream helps manage athlete’s foot through two actions.

Clotrimazole targets the fungi responsible for the infection, while betamethasone dipropionate helps relieve inflammation and itching.

This combination may be useful when a healthcare provider confirms a fungal infection accompanied by significant inflammation.

However, because corticosteroids can sometimes mask or worsen fungal infections when used incorrectly, Lotriderm should not be used for longer than prescribed.

Keeping your feet clean and dry, changing socks regularly, and avoiding prolonged moisture exposure may help reduce the risk of recurrence.

Treatment of Jock Itch (Tinea Cruris)

Lotriderm Cream may also be used to treat certain cases of jock itch, medically known as tinea cruris.

Jock itch is a fungal infection that usually affects the groin, inner thighs, and nearby skin folds.

It commonly develops in areas where warmth, moisture, and friction encourage fungal growth.

People who sweat heavily, wear tight clothing, or participate in physical activities may be more likely to develop the infection.

Symptoms often include an itchy, red, or discolored rash, scaling, irritation, and discomfort.

The rash may spread outward and develop a more noticeable border around the affected area.

Clotrimazole helps stop fungal growth, while betamethasone dipropionate reduces the inflammation responsible for itching and redness.

However, the groin is a sensitive area where topical corticosteroids may be absorbed more readily.

Lotriderm should only be applied to the affected groin skin when specifically prescribed, and treatment should be limited to the recommended duration.

Do not apply the medication to the genitals, inside skin folds unnecessarily, or to other sensitive areas without medical instructions.

Keeping the groin clean and dry and wearing breathable clothing may help support treatment.

Treatment of Ringworm (Tinea Corporis)

Lotriderm Cream may be prescribed for certain cases of ringworm, also called tinea corporis.

Despite its name, ringworm is not caused by a worm. It is a fungal infection affecting the outer layers of the skin.

Ringworm commonly causes round or oval patches of irritated skin with a raised or scaly border.

The center of the patch may appear clearer than the surrounding area, creating a ring-like appearance.

Other symptoms may include itching, redness, dryness, scaling, and irritation.

Ringworm can spread through direct contact with infected people, animals, or contaminated objects.

Clotrimazole helps eliminate the fungi responsible for the infection by interfering with their cell membranes.

Betamethasone dipropionate reduces inflammation, helping relieve redness and itching.

However, corticosteroids can sometimes change the appearance of fungal infections, making them more difficult to recognize.

This is sometimes called tinea incognito, a fungal infection whose typical appearance has been altered by corticosteroid use.

For this reason, Lotriderm should only be used when a healthcare provider has confirmed the diagnosis and determined that combination treatment is appropriate.

Treatment of Inflamed Fungal Skin Infections

Lotriderm Cream is specifically intended for fungal skin infections accompanied by inflammation and itching.

These infections may cause discomfort because the body’s immune system reacts to the presence of fungi in the skin.

The resulting inflammation may produce redness, swelling, burning, irritation, and persistent itching.

Lotriderm addresses both the fungal infection and the associated inflammation.

Clotrimazole helps eliminate susceptible fungi, while betamethasone dipropionate helps reduce the inflammatory response.

This may provide relief from itching and redness while the antifungal ingredient treats the underlying infection.

However, Lotriderm is not a general treatment for eczema, psoriasis, or allergic skin reactions that are unrelated to fungal infections.

The Canadian product monograph specifically identifies its use for athlete’s foot, jock itch, and ringworm complicated by inflammatory itching. 

How Does Lotriderm Cream Work?

Lotriderm Cream combines an antifungal medication with a potent topical corticosteroid.

These ingredients work through different mechanisms to treat fungal skin infections and relieve associated symptoms.

Clotrimazole Stops Fungal Growth

Clotrimazole belongs to a class of antifungal medications called imidazoles.

It works by interfering with the production of ergosterol, a substance that fungi need to maintain healthy cell membranes.

The cell membrane is a protective outer layer that helps fungal cells maintain their normal structure and function.

When ergosterol production is disrupted, the fungal cell membrane becomes damaged and less effective.

This interferes with fungal growth and can lead to the destruction of susceptible fungal cells.

By reducing the fungal infection, clotrimazole helps the affected skin gradually recover.

Betamethasone Dipropionate Reduces Inflammation

Betamethasone dipropionate is a potent topical corticosteroid.

It works by suppressing certain inflammatory responses in the skin.

When a fungal infection causes irritation, the immune system releases chemical substances that contribute to redness, swelling, and itching.

Betamethasone dipropionate reduces the activity of these inflammatory substances.

It also helps narrow small blood vessels in the affected skin, which can reduce redness and swelling.

As inflammation decreases, the skin may become less itchy and uncomfortable.

However, betamethasone does not kill fungi. This is why it is combined with clotrimazole.

Both Ingredients Provide Combined Treatment

Clotrimazole and betamethasone dipropionate work together to address two aspects of an inflamed fungal infection.

Clotrimazole targets the fungi responsible for the infection, while betamethasone dipropionate reduces the symptoms caused by inflammation.

This combination may provide symptom relief while the antifungal treatment takes effect.

However, relief from itching or redness does not necessarily mean that the fungal infection has completely cleared.

Continue using Lotriderm according to your prescribed treatment schedule, even if your symptoms improve before the recommended treatment period ends.

How Long Does Lotriderm Cream Take to Work?

Lotriderm Cream begins acting against susceptible fungi and reducing inflammation after application.

Some people may notice less itching, redness, or irritation within the first few days of treatment.

However, complete improvement may take longer, depending on the location and severity of the infection.

According to the Canadian product monograph, the usual treatment duration is approximately two weeks for jock itch and ringworm and four weeks for athlete’s foot.

Your healthcare provider will determine the appropriate treatment duration.

If your symptoms do not improve within the expected period, your healthcare provider may reassess the diagnosis or recommend another treatment.

Do not continue using Lotriderm longer than prescribed because prolonged corticosteroid exposure may cause skin thinning and other side effects. 

Important Information About Lotriderm Cream

Lotriderm Cream contains clotrimazole 1% and betamethasone dipropionate 0.05%.

It is intended for external use on the skin only and is generally applied in a thin layer twice daily, as prescribed.

Avoid contact with the eyes, mouth, and other sensitive areas. Do not cover treated skin with airtight bandages or plastic wraps.

Because betamethasone dipropionate is a potent corticosteroid, excessive or prolonged use may increase the risk of skin thinning, stretch marks, irritation, and unwanted absorption into the bloodstream.

The safety and effectiveness of Lotriderm Cream have not been established in children younger than 12 years under the Canadian product monograph.

Tell your healthcare provider if you have an untreated bacterial or viral skin infection, a history of corticosteroid allergy, or another medical condition that may affect treatment.

Lotriderm Cream is a prescription topical medication used to treat certain fungal skin infections, including athlete’s foot, jock itch, and ringworm.

It contains two active ingredients that work together to treat the infection and relieve uncomfortable skin symptoms.

Clotrimazole 1% is an antifungal medication that helps stop the growth of fungi responsible for skin infections.

Betamethasone dipropionate 0.05% is a potent corticosteroid that helps reduce inflammation, redness, swelling, and itching.

Lotriderm Cream is usually applied twice daily, once in the morning and once in the evening, according to your healthcare provider’s instructions.

Apply a thin, even layer to the affected skin and gently rub it in. Do not use more cream or apply it more frequently than prescribed.

Lotriderm is intended for external use on the skin only. Avoid contact with the eyes, mouth, and other sensitive areas.

How to Apply Lotriderm Cream Correctly

Proper application helps the medication reach the affected skin while reducing the risk of irritation and unnecessary corticosteroid absorption.

Follow these steps when applying Lotriderm Cream:

  1. Wash Your Hands: Clean your hands thoroughly with soap and water before handling the medication.
  2. Clean the Affected Area: Gently wash the infected skin using water and a mild cleanser. Avoid harsh soaps or excessive scrubbing that may worsen irritation.
  3. Dry the Skin: Pat the area dry with a clean towel. This is particularly important for fungal infections because moisture can encourage fungal growth.
  4. Apply a Thin Layer: Place a small amount of Lotriderm Cream on your fingertips and spread it evenly over the affected area and the immediately surrounding skin, as directed by your healthcare provider.
  5. Rub Gently: Massage the cream lightly into the skin until it is evenly distributed. Avoid scratching or rubbing the irritated area aggressively.
  6. Follow Your Prescribed Schedule: Apply the cream in the morning and evening, or according to the instructions on your prescription label.
  7. Leave the Area Uncovered: Do not use airtight bandages, plastic wraps, or other occlusive dressings unless specifically directed by your healthcare provider.
  8. Wash Your Hands After Application: Clean your hands thoroughly to avoid accidentally transferring the medication or fungal organisms to other areas of your body. If your hands are the area being treated, follow your healthcare provider’s instructions.
  9. Avoid Sensitive Areas: Keep the cream away from your eyes, mouth, and other areas not included in your prescribed treatment.
  10. Complete the Recommended Treatment: Continue using Lotriderm for the duration prescribed, even if itching and redness improve before the infection has fully cleared.

How Often Should I Apply Lotriderm Cream?

Lotriderm Cream is generally applied twice daily.

Apply the cream once in the morning and once in the evening, leaving approximately 12 hours between applications when practical.

Your healthcare provider may recommend a different treatment schedule depending on your skin condition and medical history.

Using Lotriderm more frequently than prescribed does not necessarily eliminate the fungal infection faster.

Instead, excessive application increases exposure to betamethasone dipropionate, a potent corticosteroid.

This may raise the risk of skin thinning, irritation, stretch marks, and other unwanted side effects.

Do not increase the amount or frequency of application without consulting your healthcare provider.

How Long Should I Use Lotriderm Cream?

The length of treatment depends on the type of fungal infection, its severity, and how well your skin responds.

For jock itch (tinea cruris) and ringworm (tinea corporis), treatment is generally limited to two weeks.

For athlete’s foot (tinea pedis), treatment may continue for up to four weeks.

If symptoms improve before the end of treatment, follow your healthcare provider’s instructions about when to stop.

However, do not extend treatment beyond the recommended period without medical evaluation.

Lotriderm is not intended for continuous long-term use because it contains a potent corticosteroid.

Prolonged use may increase the risk of skin thinning, stretch marks, changes in skin color, and increased medication absorption.

The original instructions also mention candidiasis, a yeast infection caused by Candida species. The standard two-week treatment schedule for ringworm and jock itch should not automatically be applied to candidiasis. Lotriderm is primarily indicated for specific dermatophyte infections, and yeast infections may require a different antifungal treatment.

If your skin condition has not improved within the recommended treatment period, contact your healthcare provider for reassessment.

Why Should I Wash My Hands After Applying Lotriderm Cream?

Washing your hands after applying Lotriderm helps remove any remaining medication and reduces the risk of spreading the fungal infection to other parts of your body.

Fungal infections can spread through direct skin contact or contaminated objects, including towels and clothing.

After applying the cream, wash your hands thoroughly with soap and water unless your hands are the area being treated.

Avoid touching your eyes, mouth, or other sensitive areas before washing your hands.

Do not share towels, clothing, or personal items with other people while you have an active fungal infection.

Can I Cover the Treated Area After Applying Lotriderm Cream?

Do not cover the treated skin with airtight bandages, plastic wraps, or other occlusive dressings unless specifically instructed by your healthcare provider.

Lotriderm contains betamethasone dipropionate, a potent corticosteroid that can be absorbed through the skin.

Airtight coverings trap moisture and may increase the amount of medication absorbed into the bloodstream.

Excessive absorption can increase the risk of skin thinning, stretch marks, and other corticosteroid-related side effects.

For fungal infections, trapping moisture may also create conditions that encourage fungal growth.

Wear loose, breathable clothing when possible, particularly when treating athlete’s foot or jock itch.

Leave the treated skin uncovered unless your healthcare provider gives you different instructions.

What Should I Do If I Miss an Application of Lotriderm Cream?

If you forget to apply Lotriderm Cream, continue with your next scheduled application.

The Canadian product monograph advises patients who miss a dose to resume treatment at the next scheduled application. 

Do not apply twice as much cream to make up for a missed application.

Using extra medication will not necessarily improve the infection faster and may increase the risk of skin irritation or unwanted corticosteroid absorption.

If you frequently miss applications, consider setting a reminder for your morning and evening treatments.

Contact your healthcare provider or pharmacist if you are unsure how to resume your prescribed schedule.

What Should I Do If Lotriderm Cream Is Not Working?

Lotriderm Cream may begin relieving redness and itching within the first three to five days of treatment.

However, symptom relief does not necessarily mean the underlying fungal infection has been completely eliminated.

If you are treating jock itch or ringworm and notice no improvement after one week, contact your healthcare provider.

For athlete’s foot, your healthcare provider should reassess the condition if there is no improvement after two weeks.

If ringworm or jock itch persists after two weeks, or athlete’s foot persists after four weeks, the Canadian product monograph recommends discontinuing Lotriderm and considering alternative treatment. 

Your healthcare provider may need to confirm the diagnosis, check for another skin condition, or recommend an antifungal medication without a corticosteroid.

Important Precautions When Using Lotriderm Cream

Lotriderm Cream should only be used for the fungal skin infection for which it was prescribed.

Avoid applying it to your face, eyes, mouth, or other sensitive areas. Do not use it on open wounds or untreated bacterial or viral skin infections.

Because the cream contains a potent corticosteroid, prolonged use may cause skin thinning, stretch marks, and changes in skin color.

Do not apply Lotriderm to large areas or continue treatment beyond the prescribed duration without medical supervision.

Tell your healthcare provider if you are pregnant, breastfeeding, or have previously experienced allergic reactions to antifungal medications or corticosteroids.

Contact your healthcare provider if you develop worsening redness, persistent burning, swelling, or signs of an allergic reaction.

Common Side Effects of Lotriderm Cream (Clotrimazole Betamethasone Dipropionate):

  • Blistering, stinging, itching, peeling, redness, swelling, or other signs of skin irritation not present before use of this medication
  • Dryness of the skin
  • Excessive hair growth
  • Itching skin
  • Numbness of the hands and feet
  • Patches of lighter skin tone
  • Peeling skin
  • Skin redness around the mouth

Serious Side Effects of Lotriderm Cream (Clotrimazole Betamethasone Dipropionate):

  • Allergic skin reactions
  • Blurred vision
  • Darkening of the skin
  • Dermatitis (skin inflammation) around the mouth
  • Excessive hair growth
  • Hives
  • Inflammation of the hair follicles
  • Other skin infections, thinning of the skin, and red marks
  • Reddish purple lines on the skin
  • Skin infection
  • Stretch marks
  • Thinning of the skin or easy bruising
  • Tingling or pins and needles sensation on the skin

Lotriderm Cream (Clotrimazole Betamethasone Dipropionate) is available in the following forms and strength:

Lotriderm Cream: Cream

  • 1%/0.05%

Clotrimazole/Betamethasone Dipropionate: Cream

  • 1%/0.05%

Lotriderm Cream is a prescription topical medication used to treat certain fungal skin infections, including athlete’s foot, jock itch, and ringworm, when they are accompanied by inflammation, redness, and itching.

It contains two active ingredients:

  • Clotrimazole 1%: An antifungal medication that helps stop the growth of fungi responsible for skin infections.
  • Betamethasone dipropionate 0.05%: A potent topical corticosteroid that helps reduce redness, swelling, itching, and inflammation.

Although Lotriderm Cream can be effective when used correctly, it may cause side effects, particularly when applied to large areas of skin, sensitive areas, or for longer than prescribed.

Before using Lotriderm Cream, tell your healthcare provider about any allergies, existing skin conditions, medical problems, and medications you currently take.

Allergic Reactions and Hypersensitivity

Do not use Lotriderm Cream if you have a known allergy to clotrimazole, betamethasone dipropionate, or any other ingredient in the formulation.

Clotrimazole belongs to a group of antifungal medications called imidazoles, while betamethasone dipropionate is a corticosteroid.

Some people may develop a local allergic reaction to one of these ingredients or another substance in the cream.

Possible symptoms include increased redness, itching, burning, swelling, or a new rash around the treated area.

These symptoms may resemble the original skin infection, making it difficult to recognize an allergic reaction.

If your skin becomes increasingly irritated after applying Lotriderm, stop using the medication and contact your healthcare provider.

Seek emergency medical attention if you experience difficulty breathing, swelling of the face or throat, or other signs of a severe allergic reaction.

Pregnancy and Lotriderm Cream

Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant before using Lotriderm Cream.

There is limited information about the safety of this combination medication during pregnancy.

Although the cream is applied to the skin, some medication may still enter the bloodstream.

The amount absorbed depends on several factors, including the size of the treated area, the condition of the skin, how often the cream is applied, and whether the skin is covered.

Betamethasone dipropionate is a potent corticosteroid. Applying large amounts or using it for prolonged periods may increase systemic absorption.

Your healthcare provider will consider whether the expected benefits of treatment outweigh the potential risks.

If Lotriderm is considered necessary during pregnancy, your healthcare provider may recommend using the smallest effective amount for the shortest appropriate duration.

Do not use Lotriderm Cream during pregnancy without medical advice, especially over large areas of skin or for extended periods.

Breastfeeding and Lotriderm Cream

Consult your healthcare provider before using Lotriderm Cream if you are breastfeeding.

It is not known whether the active ingredients pass into breast milk in clinically significant amounts after topical application.

Because Lotriderm is applied to the skin, exposure throughout the body is generally lower than with medications taken by mouth. However, absorption can increase when large areas are treated or when the medication is used on damaged skin.

Your healthcare provider will consider the benefits of treatment and any potential risks to your baby.

Avoid applying Lotriderm Cream directly to the breasts or nipples while breastfeeding unless your healthcare provider has specifically assessed its use.

This helps prevent the baby from accidentally swallowing medication during feeding.

Wash your hands after applying the cream and keep treated areas from coming into direct contact with your baby’s skin.

Use in Children Under 12 Years

Lotriderm Cream is not recommended for children younger than 12 years under Canadian prescribing guidance.

Children may absorb proportionally more topical corticosteroid than adults because of differences in their skin and their larger skin surface area relative to body weight.

Excessive absorption of betamethasone dipropionate may affect the body’s normal production of cortisol, a hormone involved in metabolism and the response to stress.

This can interfere with the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production.

Possible complications of excessive corticosteroid exposure in children include adrenal suppression, Cushing-like symptoms, and effects on growth.

Do not use Lotriderm Cream in children younger than 12 unless a specialist has carefully assessed the situation and recommended an appropriate treatment.

For children aged 12 or older, follow the prescribed treatment duration and avoid using more cream than directed.

Skin Thinning and Stretch Marks

Prolonged use of Lotriderm Cream may cause skin thinning, medically known as skin atrophy.

Betamethasone dipropionate is a potent topical corticosteroid that reduces inflammation by affecting immune activity in the skin.

However, excessive corticosteroid exposure may also interfere with the production of collagen and other substances that help maintain skin strength and elasticity.

As a result, the treated skin may become thinner, more fragile, or more easily bruised.

Other possible effects include visible small blood vessels, changes in skin color, and stretch marks.

Stretch marks, also called striae, may appear as narrow lines or streaks on the skin and can become permanent.

These effects are more likely when Lotriderm is applied to large areas, used for prolonged periods, or applied to sensitive skin.

Use only a thin layer and do not continue treatment longer than prescribed.

Avoid Airtight Bandages and Occlusive Dressings

Do not cover skin treated with Lotriderm Cream using plastic wraps, airtight bandages, or other occlusive dressings unless specifically instructed by your healthcare provider.

Occlusive dressings trap moisture and prevent air from reaching the skin.

This may significantly increase the absorption of betamethasone dipropionate.

Higher corticosteroid absorption increases the risk of skin thinning, stretch marks, irritation, and systemic side effects.

Because Lotriderm also treats fungal infections, trapping heat and moisture may create conditions that encourage fungal growth.

Loose, breathable clothing is generally preferable, particularly when treating fungal infections in areas prone to sweating.

If you need to cover the affected skin, ask your healthcare provider which type of dressing is appropriate.

Glaucoma, Cataracts, and Eye Problems

Lotriderm Cream should not be applied to the eyes or eyelids.

It contains betamethasone dipropionate, a potent corticosteroid that may cause serious eye-related complications if repeatedly applied near or into the eyes.

Prolonged corticosteroid exposure around the eyes may increase the risk of elevated intraocular pressure, glaucoma, and cataracts.

Glaucoma is a condition that can damage the optic nerve, potentially leading to permanent vision loss.

Cataracts occur when the eye’s natural lens becomes cloudy, causing blurred vision and difficulty seeing clearly.

People with a history of glaucoma, cataracts, or increased eye pressure should inform their healthcare provider before using Lotriderm near the face.

Avoid applying Lotriderm Cream to the eyelids or surrounding eye area unless a specialist specifically directs you to do so.

If the cream accidentally enters your eyes, rinse them thoroughly with clean water.

Seek medical attention if irritation, pain, or blurred vision continues.

Broken Skin and Existing Skin Infections

Lotriderm Cream should not be applied to open wounds, deep cuts, or severely damaged skin unless your healthcare provider specifically recommends it.

Damaged skin may absorb more medication than healthy skin, increasing the risk of corticosteroid-related side effects.

Lotriderm also should not be used to treat untreated bacterial or viral skin infections, including herpes simplex and chickenpox.

Betamethasone dipropionate suppresses inflammation, which may hide the symptoms of an infection or allow it to become worse.

Although clotrimazole treats certain fungal infections, it does not kill bacteria or viruses.

If the affected skin becomes increasingly painful, swollen, warm, or develops pus, contact your healthcare provider.

These symptoms may indicate a bacterial infection or another condition requiring different treatment.

Do not apply Lotriderm to an undiagnosed rash or infected wound without medical evaluation. 

Prolonged Use and Systemic Corticosteroid Effects

Lotriderm Cream should only be used for the recommended treatment period.

The usual treatment duration is up to two weeks for ringworm and jock itch, or up to four weeks for athlete’s foot.

Using the medication for longer than recommended increases the risk of corticosteroid-related side effects.

When excessive amounts of betamethasone are absorbed through the skin, the medication may affect hormone production throughout the body.

One possible complication is suppression of the hypothalamic-pituitary-adrenal (HPA) axis.

The HPA axis regulates the production of cortisol, a hormone that helps control metabolism, blood pressure, and the body’s response to stress.

Excessive corticosteroid absorption may reduce the body’s natural cortisol production.

In some cases, it may also cause symptoms resembling Cushing’s syndrome, such as weight gain, a rounded face, and changes in blood sugar levels.

These complications are more likely when potent corticosteroids are applied to large skin areas, used continuously, or covered with airtight dressings.

Use the smallest amount needed to cover the affected skin and do not exceed the prescribed treatment duration. 

Applying Lotriderm Cream to the Face, Groin, and Underarms

Use extra caution when applying Lotriderm Cream to sensitive skin.

The face, groin, and underarms have areas of relatively thin skin, making them more vulnerable to unwanted corticosteroid effects.

Applying potent corticosteroids to these areas may increase the risk of irritation, skin thinning, stretch marks, and changes in skin color.

Lotriderm should not be used on the face or underarms unless specifically directed by your healthcare provider.

Although Lotriderm may be prescribed for jock itch, which affects the groin and inner thighs, it should only be applied to the affected skin as directed.

Avoid applying it to the genitals, mucous membranes, or other sensitive areas without medical instructions.

Prolonged corticosteroid use on the face may also cause or worsen acne-like eruptions, rosacea, and perioral dermatitis.

Do not use Lotriderm on sensitive areas simply because the skin is red, itchy, or inflamed. Your healthcare provider should first determine whether a fungal infection is present.

Medication Interactions

Tell your healthcare provider about all medications, creams, and supplements you use before starting Lotriderm.

Because Lotriderm is applied directly to the skin, interactions affecting the whole body are generally less likely than with medications taken by mouth.

However, interactions and overlapping side effects are still possible.

Using Lotriderm with other topical corticosteroids may increase the risk of skin thinning, irritation, and excessive corticosteroid exposure.

Applying several medicated creams to the same area may also cause irritation or affect how the products are absorbed.

Certain medications that suppress the immune system may influence how fungal infections are treated.

If you use other prescription creams, antifungal products, or medicated skin treatments, ask your healthcare provider or pharmacist whether they can be applied to the same area.

Do not combine Lotriderm with other corticosteroid-containing creams unless specifically instructed by your healthcare provider.

Avoid Contact With the Eyes

Lotriderm Cream is intended for external use on the skin only.

Do not apply it directly to the eyes or use it as an eye medication.

Accidental exposure may cause burning, stinging, redness, or irritation.

Repeated exposure to potent corticosteroids around the eyes may also increase the risk of glaucoma and cataracts.

When applying Lotriderm near the face, take care to prevent the cream from spreading toward the eyes.

Wash your hands thoroughly after each application.

If Lotriderm accidentally enters your eyes, rinse them gently with plenty of clean water.

Contact your healthcare provider if irritation continues or you experience eye pain or blurred vision.

When to Contact Your Healthcare Provider

Contact your healthcare provider if your rash becomes worse, spreads to other areas, or does not improve within the expected treatment period.

You should also seek medical advice if you develop persistent burning, unusual skin discoloration, increasing redness, or signs of skin thinning.

If you are treating ringworm or jock itch and do not notice improvement after one week, your healthcare provider should reassess the condition. For athlete’s foot, reassessment is recommended if there is no improvement after two weeks.

Seek emergency medical attention if you develop difficulty breathing, severe facial swelling, or swelling of the tongue or throat.

Can Lotriderm Cream Be Used for Children?

Lotriderm Cream is generally not recommended for children younger than 12 years of age. The medication contains betamethasone dipropionate, a potent corticosteroid that helps reduce inflammation, redness, and itching. Children are more sensitive to topical corticosteroids because their skin can absorb proportionally more medication than adult skin. Using Lotriderm Cream on large areas of skin or for prolonged periods may increase the risk of side effects, including skin thinning, stretch marks, and changes in skin color. Excessive absorption may also affect the body’s natural production of cortisol, an important hormone involved in growth, metabolism, and the response to stress. This condition is called hypothalamic-pituitary-adrenal (HPA) axis suppression. In children, prolonged exposure to potent corticosteroids may also affect normal growth and development. The safety and effectiveness of Lotriderm Cream have not been established in children younger than 12 years under Canadian prescribing guidance. If your child has a fungal skin infection, consult a healthcare provider before starting treatment. An antifungal medication without a corticosteroid may be more appropriate, depending on the type and severity of the infection. For children aged 12 years and older, Lotriderm should only be used as prescribed, following the recommended application schedule and treatment duration.

How Often Should I Apply Lotriderm Cream?

Lotriderm Cream is usually applied twice daily, once in the morning and once in the evening. Before applying the medication, gently wash the affected skin with water and a mild cleanser. Pat the area dry using a clean towel. Apply a thin layer of Lotriderm Cream over the affected skin and the immediately surrounding area, as directed by your healthcare provider. Gently rub the cream into the skin until it is evenly distributed. Wash your hands thoroughly after application, unless your hands are the area being treated. Avoid covering the treated skin with airtight bandages, plastic wraps, or other occlusive dressings unless instructed by your healthcare provider. These coverings can increase the absorption of betamethasone dipropionate and raise the risk of side effects. Using extra cream or applying it more frequently will not necessarily clear the infection faster. Instead, excessive application may increase the risk of skin irritation, thinning, and other corticosteroid-related complications. Do not apply Lotriderm Cream more than twice daily unless your healthcare provider specifically instructs you to do so. Follow the recommended treatment duration, which is generally up to two weeks for jock itch and ringworm or four weeks for athlete’s foot. 

Can Lotriderm Cream Be Used on the Face?

Lotriderm Cream is generally not recommended for use on the face. The skin on the face is thinner and more sensitive than the skin on many other parts of the body. Because Lotriderm contains the potent corticosteroid betamethasone dipropionate, applying it to facial skin may increase the risk of unwanted side effects. Possible effects include skin thinning, irritation, changes in skin colour, acne-like breakouts, and visible small blood vessels. Prolonged corticosteroid use on the face may also cause or worsen certain skin conditions, including rosacea and perioral dermatitis. Perioral dermatitis is an inflammatory skin condition that causes small bumps and irritation around the mouth, nose, or eyes. Lotriderm should also be kept away from the eyes and eyelids. Repeated corticosteroid exposure around the eyes may increase the risk of elevated eye pressure, glaucoma, and cataracts. Do not apply Lotriderm Cream to your face or around your eyes unless a healthcare professional specifically directs you to do so. If you develop a fungal infection on your face, consult your healthcare provider. They may recommend an antifungal medication without a potent corticosteroid or another treatment that is more appropriate for sensitive facial skin. If Lotriderm accidentally enters your eyes, rinse them thoroughly with clean water and seek medical advice if irritation continues.

How Long Does It Take for Lotriderm Cream to Work?

Lotriderm Cream may begin relieving redness, itching, and inflammation within the first few days of treatment. However, the time needed for noticeable improvement depends on the type of fungal infection, its severity, and how your skin responds to the medication. Lotriderm contains two active ingredients that work in different ways. Clotrimazole is an antifungal medication that interferes with fungal cell membranes, helping stop fungal growth and treat the infection. Betamethasone dipropionate is a potent corticosteroid that reduces inflammation, swelling, redness, and itching. Because betamethasone helps reduce inflammation, you may notice symptom relief before the fungal infection has completely cleared. Improvement in itching or redness does not necessarily mean the infection is fully treated. The usual treatment duration depends on the infection being treated. For ringworm (tinea corporis) and jock itch (tinea cruris), treatment is generally limited to two weeks. For athlete’s foot (tinea pedis), treatment may continue for up to four weeks. If ringworm or jock itch does not begin improving within one week, contact your healthcare provider for reassessment. For athlete’s foot, seek medical advice if there is no improvement after two weeks. Your healthcare provider may need to confirm the diagnosis, check for another skin condition, or recommend a different antifungal treatment. Continue following your prescribed treatment schedule even if your symptoms improve, but do not extend treatment beyond the recommended duration without medical advice. If your rash becomes worse, spreads, or causes increasing pain or irritation, contact your healthcare provider rather than applying more cream.

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Additional Information Book
Generic name:

Clotrimazole/Betamethasone Dipropionate

Formulation:

Cream

Strength(s):

1%/0.05%

Quantities Available:

15g, 45g, 60g

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How to Order

How much Lotriderm Cream can I order at once from a Canadian pharmacy?

When ordering Lotriderm Cream (clotrimazole/betamethasone dipropionate) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Lotriderm Cream is commonly prescribed to be applied to the affected area twice daily. The amount of cream you will order for a 90-day supply will be based on the size of the area being treated and frequency of application.

Do you sell clotrimazole/betamethasone dipropionate?

Yes, we sell clotrimazole/betamethasone dipropionate on our website. You can enjoy low prices when you order through us. To purchase clotrimazole/betamethasone dipropionate, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Lotriderm Cream (clotrimazole/betamethasone dipropionate) to the United States?

Yes, we ship Lotriderm Cream (clotrimazole/betamethasone dipropionate) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Lotriderm Cream (Clotrimazole/Betamethasone Dipropionate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Lotriderm Cream (Clotrimazole/Betamethasone Dipropionate).