Indications
Vfend is a medication used in the treatment of serious fungal infections. It is typically used to treat infections caused by Aspergillus and Candida fungi, among others. It contains the active substance voriconazole, which belongs to a class of antifungal drugs called azoles.
Vfend works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, which leads to the disruption of fungal cell walls and the death of the fungus. By doing so, Voriconazole impairs the fungal cell membrane, leading to the death of the fungi. This mechanism of action distinguishes Voriconazole from other types of antifungal medications, such as azoles, which work by inhibiting the synthesis of ergosterol.
Uses and Dosage
Voriconazole is available in tablet form to be taken orally. It should be taken at the same time every day, every 12 hours, as directed by your doctor. To ensure the best results, take Voriconazole at evenly spaced times and, if necessary, set a reminder to help you remember. Take Voriconazole at least 1 hour before or 1 hour after meals.
The recommended dosage of Voriconazole may vary depending on the patient's age and weight, and the severity and type of infection being treated. The typical recommended dosage for adults is 200 mg orally every 12 hours, and the dose may be increased to 300 mg orally every 12 hours depending on the patient's response and the severity of the infection. For pediatric patients, the dosage will be adjusted based on their weight and age.
Continue to take the full prescribed amount of Voriconazole, even if symptoms improve before the end of the treatment. Stopping the medication too early might result in a relapse of the infection. If your condition does not improve or worsens, inform your doctor.
Side effect
Common Side Effects of Vfend (Voriconazole):
- Abnormal liver function tests
- Fast heart rate
- Hallucination
- Headache
- Nausea
- Rash
- Vision changes
- Vomiting
Serious Side Effects of Vfend (Voriconazole):
- Burning eyes
- Difficulty breathing
- Fainting
- Fast or pounding heartbeats
- Fever
- Flu-like symptoms
- Fluttering in your chest
- Hives
- Itching
- Little or no urination
- Shortness of breath
- Skin pain red or purple skin rash with blistering and peeling
- Slow breathing
- Slow heart rate
- Sore throat
- Sudden dizziness
- Sunburn
- Swelling in your feet or ankles
- Swelling of your face lips tongue or throat
- Tiredness
- Weak pulse
- Yellowing of the skin or eyes (jaundice)
Form and Strength
Vfend (Voriconazole) is available in the following forms and strength:
Voriconazole: Tablet
- 50 mg
- 200 mg
Caution
- Vfend may cause serious side effects such as liver problems, vision changes, and skin reactions, so it should only be taken under the guidance and supervision of a healthcare professional.
- Voriconazole may interact with other medications, including certain antibiotics, antifungal drugs, and blood-thinning medications.
- Voriconazole may cause QT interval prolongation, which can lead to irregular heartbeats. If you experience symptoms such as a fast or irregular heartbeat, dizziness, or fainting, you should seek medical attention immediately.
- Vfend should not be used during pregnancy or breastfeeding unless the potential benefit outweighs the potential risk to the fetus or nursing baby.
- Voriconazole may cause photosensitivity, meaning that your skin may become more sensitive to sunlight or UV radiation. You should avoid prolonged sun exposure and wear protective clothing and sunscreen when outdoors.
- Vfend may also cause other side effects, such as nausea, vomiting, diarrhea, headache, and fever. If you experience any unusual symptoms while taking Vfend, you should contact your healthcare provider.
- Vfend may decrease the effectiveness of hormonal contraceptives, so an alternative form of contraception should be used while taking Vfend.
- People with liver or kidney problems should use Voriconazole with caution, as it may cause further damage to these organs.
- Vfend may cause rare but serious allergic reactions, such as anaphylaxis, so you should seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or hives.
- In rare cases, Voriconazole may cause hallucinations, confusion, or other psychiatric symptoms. If you experience any unusual changes in mood or behavior while taking Vfend, you should contact your healthcare provider.
Frequently Asked Questions (FAQ)
Can Vfend be taken with food?
Vfend can be taken with or without food. However, taking it with a high-fat meal may increase the absorption of the medication.
How should Vfend be stored?
Vfend should be stored at room temperature away from moisture and heat. It should also be kept out of reach of children.
What should I do if I miss a dose of Vfend?
If you miss a dose of Vfend, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the missed dose and take your next dose as scheduled.
Can Vfend be used in children?
Vfend can be used in children, but the dosage may need to be adjusted based on the child's weight and age.
How long does treatment with Vfend last?
The length of treatment with Vfend will depend on the type and severity of the infection being treated, as well as your response to the medication. Your healthcare provider will determine the appropriate length of treatment.
Resources
- https://www.goodrx.com/voriconazole/what-is
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021266s039,021267s050,021630s029lbl.pdf
- https://www.drugs.com/vfend.html
- https://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/021266Orig1s009.pdf
- https://www.rxlist.com/vfend-drug.htm
- https://www.webmd.com/drugs/2/drug-63751-5326/vfend-oral/voriconazole-oral/details
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