Lioresal Intrathecal (Baclofen)

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Lioresal Intrathecal Brand
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Baclofen (Generic alternate to Lioresal Intrathecal) Generic

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Lioresal Intrathecal (generically known as Baclofen) is a prescription medication used to treat severe spasticity caused by injury to the spinal cord or multiple sclerosis. Baclofen belongs to two groups of medications known as muscle relaxants and antispastics. It is used to treat spasticity (uncontrolled muscle movements) caused by multiple sclerosis, spinal cord injuries, or spinal cord diseases.

Baclofen works by decreasing the activity of certain nerve receptors in the spinal cord, which leads to reduced muscle spasms and increased muscle relaxation. By delivering the drug directly into the spinal fluid, Lioresal Intrathecal can provide more effective relief of severe spasticity that cannot be adequately managed through oral medications.

Use and Dosage

Lioresal Intrathecal (baclofen injection) ampules are intended for single-use only and are packaged in 0.05 mg/1 mL (50 mcg/mL) doses. They are used in a pump that is surgically implanted under the skin of your abdomen, which delivers the medication directly into the spinal fluid through a catheter.

Your healthcare provider will determine the appropriate dosage for you based on your individual needs. Follow the specific instructions provided by your healthcare provider for the use of Lioresal Intrathecal. You should not attempt to administer the medication on your own without proper training and instruction.

Note that abrupt withdrawal of intrathecal baclofen may occur in patients using the drug over two months, which may result in a hypermetabolic state with potentially fatal consequences. Monitoring for early clinical and laboratory signs of withdrawal is necessary. If you have any questions or concerns about the use of Lioresal Intrathecal ampules, you should consult with your healthcare provider.

Lioresal Intrathecal can be given exactly as prescribed by your doctor. Keep your appointments to have the pump refilled, otherwise spasms may recur.

Side Effects

Common Side Effects of Lioresal Intrathecal (Baclofen):

  • Abdominal or stomach pain or discomfort
  • Constipation
  • Decreased sexual ability
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Frequent urination
  • Headache
  • Increased perspiration
  • Low blood pressure (e.g., fainting, dizziness, lightheadedness, blurred vision, nausea)
  • Nausea
  • Tiredness
  • Trouble sleeping
  • Vomiting
  • Weakness

Serious Side Effects of Lioresal Intrathecal (Baclofen):

  • Breathing problems
  • Confusion
  • Difficulty speaking
  • Excessive eating
  • False sense of well-being
  • Frequent urination
  • Fruity breath odor
  • Hallucinations (seeing or hearing things that aren't there)
  • Increased thirst
  • Loss of coordination
  • Muscle pain
  • Nightmares or vivid dreams
  • Poor wound healing, infections
  • Skin rash or hives
  • Slow heartbeat
  • Tingling or numbness of the hands or feet
  • Trembling
  • Uncontrolled eye movements
  • Unexplained weight loss
  • Vision changes

Forms and Strength

Lioresal Intrathecal (Baclofen) is available in the following forms and strength:

Lioresal Intrathecal: Ampule

  • 2mg/mL


  • Lioresal Intrathecal should not be abruptly discontinued, as this can lead to withdrawal symptoms.
  • Patients should be monitored closely for signs of overdose, which can include respiratory depression, seizures, or coma.
  • Lioresal Intrathecal should be used with caution in patients with a history of epilepsy or other seizure disorders, as well as in patients with impaired renal function.
  • Patients should be advised to seek immediate medical attention if they experience chest pain, shortness of breath, or signs of an allergic reaction.
  • Lioresal Intrathecal should be used with caution in patients who are taking other medications that can interact with it, such as benzodiazepines. Consult with a healthcare provider before starting any new medications while on Lioresal Intrathecal therapy.
  • Patients should inform their healthcare provider if they have a history of mental health conditions such as depression or suicidal thoughts, as Lioresal Intrathecal may worsen these conditions.
  • Lioresal Intrathecal should not be used in patients with hypersensitivity to baclofen or any of its components.
  • Patients should be advised against drinking alcohol while taking Lioresal Intrathecal, as it can increase the risk of side effects such as dizziness or drowsiness.
  • Lioresal Intrathecal should not be used during pregnancy unless specifically directed by a healthcare provider.
  • Patients should also be advised that Lioresal Intrathecal may cause drowsiness or dizziness and should not operate heavy machinery or drive until they know how the medication affects them.

Frequently Asked Questions (FAQ)

Can Lioresal Intrathecal be stopped abruptly?

No, Lioresal Intrathecal should not be abruptly discontinued, as this can lead to withdrawal symptoms. Patients should work with their healthcare provider to gradually taper off the medication if needed.

What should I do if I experience side effects while on Lioresal Intrathecal?

Patients should contact their healthcare provider immediately if they experience any side effects while on Lioresal Intrathecal.

Can Lioresal Intrathecal be used in children?

Yes, Lioresal Intrathecal can be used in children with severe spasticity caused by injury to the spinal cord or multiple sclerosis. However, dosing and administration may be different in children than in adults.

How often do patients need to refill the infusion pump used for Lioresal Intrathecal?

The frequency of pump refills depends on the individual patient's dosage and infusion rate. Patients typically need to have their pump refilled every few weeks to several months.


It's important to purchase Lioresal Intrathecal from verified Canadian pharmacy.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Lioresal Intrathecal (Baclofen). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Lioresal Intrathecal (Baclofen).