Indications
Kerydin (generically known as tavaborole) topical solution, 5% is an antifungal medication indicated for the treatment of onychomycosis (toenail fungus) caused by Trichophyton rubrum or Trichophyton mentagrophytes.
Kerydin belongs to a class of drugs called oxaborole antifungal agents. It is a topical solution used on the skin and nails. When tavaborole is applied correctly and absorbed into the bloodstream, it works by blocking Leucyl-tRNA synthetase (LeuRS). LeuRS is an enzyme needed for protein synthesis. Without this enzyme, there is no protein synthesis. Hence, the fungus dies because of a reduction in fungal cell proliferation.
Use and Dosage
Kerydin Topical Solution is applied to the affected toenail(s) once a day for 48 weeks, or as directed by a healthcare professional. If this medication is used on a child, an adult should apply it for them.
To apply Kerydin Topical Solution, first clean and dry the infected toenail(s). Then, use the provided dropper to slowly apply enough solution to cover each affected toenail. Use the dropper tip to spread the medication over the toenail up to the edges, and under the tip of the toenail. Wait about 2 minutes for the solution to dry before wearing socks or shoes. If the solution comes in contact with skin around the toenail(s), use a tissue to wipe off any excess solution. Wash your hands with soap and water after applying the medication.
Do not get the solution on any other part of your body. Use Kerydin Topical Solution regularly at the same time each day for the full 48-week treatment period prescribed by your doctor. Stopping the medication too early may allow fungus to continue to grow, resulting in a return of the infection. If this medication is used on a child, an adult should apply it for them.
Side Effects
Common Side Effects of Kerydin Topical Solution (Tavaborole):
- Nail or skin exfoliation (shedding)
- Ingrown toenail
- Redness
- Inflammation
Serious Side Effects of Kerydin Topical Solution (Tavaborole):
- Persistent irritation of the affected toenail
- Serious eye symptoms such as: sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
- Serious heart symptoms such as: fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors
- Severe redness
- Symptoms of allergic reactions: rashes, hives, swelling of the face and lips, throat tightness, or difficulty breathing
- Unusual swelling
Forms and Strength
Kerydin Topical Solution (Tavaborole) is available in the following forms and strength:
Kerydin Topical Solution: Topical Solution
- 5%
Cautions
- Allergic reactions: Kerydin Topical Solution may cause allergic reactions in some people. Signs of an allergic reaction may include itching, hives, rash, difficulty breathing, and swelling of the face, mouth, or throat. If you experience any of these symptoms, seek medical attention immediately.
- Eye irritation: Kerydin Topical Solution may cause eye irritation if it comes into contact with the eyes. To avoid this, be careful not to get the solution near your eyes and wash your hands thoroughly after applying the solution.
- Skin irritation: Kerydin Topical Solution may cause skin irritation, such as redness, itching, burning, and stinging. If you experience any of these symptoms, talk to your doctor.
- Nail discoloration: Kerydin Topical Solution may cause temporary nail discoloration in some people. This usually goes away after the treatment is stopped.
- Pregnancy and breastfeeding: Kerydin Topical Solution has not been extensively studied in pregnant or breastfeeding women, talk to your doctor before using it if you are pregnant or breastfeeding.
- Drug interactions: inform your doctor about any other medications or supplements you are taking before using Kerydin Topical Solution. It may interact with certain medications and cause unwanted side effects.
- Use in children: The safety and effectiveness of Kerydin Topical Solution in children under 12 years old have not been established.
- Use in elderly patients: Elderly patients may be more sensitive to the side effects of Kerydin Topical Solution, use it with caution and under close medical supervision.
- Use as directed: Follow the instructions provided by your doctor or pharmacist when using Kerydin Topical Solution. Using too much or too little of the solution may not be effective and may increase the risk of side effects.
- Treatment duration: Kerydin Topical Solution may need to be used for several months to be effective, continue using it as directed by your doctor even if you do not see improvement right away.
Frequently Asked Questions (FAQ)
How often should Kerydin be applied?
Kerydin should be applied once daily for 48 weeks or as directed by a healthcare provider.
How should I store Kerydin?
Kerydin should be stored at room temperature, and away from heat and light. It should also be kept out of reach of children.
Can Kerydin be used in children?
The safety and effectiveness of Kerydin in children have not been established, and it is generally not recommended for use in children under the age of 18.
What should I do if I miss a dose of Kerydin?
If you miss a dose of Kerydin, apply it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
How can I prevent the recurrence of nail fungus after using Kerydin?
To prevent the recurrence of nail fungus, practice good hygiene, keep your nails clean and dry, and avoid exposing them to damp or moist conditions.
Resources
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204427s000lbl.pdf
- https://www.drugs.com/kerydin.html
- https://www.goodrx.com/tavaborole/what-is
- https://www.webmd.com/drugs/2/drug-166876/kerydin-topical/details
- https://www.rxlist.com/kerydin-drug.htm
- https://medlineplus.gov/druginfo/meds/a614049.html
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