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Kemadrin is a medication used to treat a variety of conditions such as Parkinson's disease, involuntary muscle movements, and muscle spasms. It contains the active ingredient procyclidine. Procyclidine belongs to a group of medications called anticholinergics. Kemadrin works by blocking the action of a neurotransmitter called acetylcholine in the brain, which can help to reduce the symptoms of these conditions.

Use and Dosage

Kemadrin is available in tablet form and should be taken orally, usually 3 to 4 times a day after meals and at bedtime or as directed by a healthcare professional. Swallow tablets with a glass of water, preferably with food. Your doctor may initially prescribe a low dose and slowly increase it to determine the optimal dosage based on your medical condition and response to the treatment.

Take Kemadrin regularly at the same time each day to get the most benefit from it. To avoid potential interactions, take Kemadrin at least 1 hour before antacids containing magnesium, aluminum, or calcium, and at least 1-2 hours apart from adsorbent antidiarrheals such as kaolin, pectin, attapulgite. Do not take the tablet within 2 hours after taking ketoconazole as this may prevent the complete absorption of ketoconazole.

If you are taking Kemadrin for side effects from another medication, your doctor may instruct you to take it on a regular schedule or only as needed. For Parkinson's disease, your doctor may adjust the dose of your other medications such as levodopa. Follow the doctor's instructions closely and do not stop or change the dose of your medication without their approval.

Kemadrin may sometimes cause addiction, especially for people with a substance use disorder. Do not increase the dose, take it more often, or use it for an extended period than prescribed. When discontinued, the dose should be gradually decreased rather than stopped abruptly to avoid potential worsening of symptoms.

Side Effects

Common Side Effects of Kemadrin (Procyclidine):

  • Abdominal pain
  • Blurred vision
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Flushing
  • Lightheadedness
  • Nausea
  • Nervousness
  • Vomiting
  • Weakness

Serious Side Effects of Kemadrin (Procyclidine):

  • Agitation
  • An allergic reaction (difficulty breathing closing of your throat swelling of your lips, tongue, or face or hives)
  • Anxiety
  • Confusion
  • Disorientation
  • Eye pain
  • Fast or irregular heartbeat
  • Hallucinations
  • Hyperactivity
  • Loss of consciousness
  • Rash
  • Seizures
  • Unusual behavior
  • Unusual fever

Forms and Strength

Kemadrin (Procyclidine) is available in the following forms and strength:

Kemadrin: Tablet

  • 2.5 mg
  • 5 mg

Procyclidine: Tablet

  • 5 mg


  • Procyclidine should not be used by individuals who are allergic to it or to any of its ingredients.
  • Kemadrin should be used with caution in individuals with certain medical conditions, such as heart disease, glaucoma, gastrointestinal obstruction, and urinary retention.
  • Procyclidine may interact with certain medications, such as anticholinergic drugs, antihistamines, and tricyclic antidepressants, and may cause unwanted effects.
  • Procyclidine may cause a range of side effects, such as confusion, hallucinations, dry mouth, blurred vision, dizziness, and drowsiness. If these occur, one should contact their doctor immediately.
  • Kemadrin should not be used during pregnancy or while breastfeeding unless the potential benefits outweigh the potential risks.
  • Procyclidine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery safely. Avoid these activities until you know how the medication affects you.
  • Kemadrin may worsen symptoms of mental health conditions such as depression, anxiety, and psychosis.
  • Kemadrin may interact with alcohol and smoking, which can worsen certain side effects such as dry mouth and blurred vision.
  • Kemadrin should be taken exactly as prescribed by your doctor. Follow the dosage instructions carefully to avoid overdose or underdose.

Frequently Asked Questions (FAQ)

How long does it take for Kemadrin to start working?

Kemadrin may start working within a few hours to a few days. However, the full benefits of the medication may take several weeks to become apparent.

What should I do if I miss a dose of Kemadrin?

If you miss a dose of Kemadrin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Can Kemadrin cause addiction?

Kemadrin is not considered addictive, although it may cause some dependence with long-term use. Follow the dosage instructions carefully and do not abruptly stop taking the medication without talking to your doctor first.

Can Kemadrin be used in children?

Kemadrin is not recommended for use in children under the age of 18 years of age.


Additional information

Generic name:





2.5mg, 5mg

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84, 100


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Kemadrin (Procyclidine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Kemadrin (Procyclidine).