Before taking Invokamet, tell your healthcare provider about your complete medical history, including any medical conditions, allergies, and all medications you are taking.
Do Not Take Other Products Containing Metformin
Invokamet already contains metformin. Do not take another medication that contains metformin unless your healthcare provider specifically instructs you to do so.
If you take other diabetes medications, your healthcare provider will determine whether they can be safely used together with Invokamet.
Lactic Acidosis
Because Invokamet contains metformin, it carries a rare but serious risk of lactic acidosis, a medical emergency that requires immediate treatment.
Seek emergency medical attention right away if you develop symptoms such as:
- Unusual muscle pain or weakness.
- Severe tiredness or extreme fatigue.
- Trouble breathing.
- Stomach pain.
- Nausea or vomiting.
- Feeling cold, especially in your arms or legs.
- Dizziness or lightheadedness.
- Slow or irregular heartbeat.
The risk of lactic acidosis is higher in people with severe kidney disease, liver disease, dehydration, or excessive alcohol use.
Kidney Problems
Invokamet may affect kidney function, particularly in people with existing kidney disease or those who become dehydrated.
Contact your healthcare provider if you notice symptoms such as:
- Swelling of the feet, ankles, or legs.
- Changes in how often you urinate.
- Changes in the color or amount of urine.
- Shortness of breath.
- Unusual fatigue.
Your healthcare provider will monitor your kidney function before and during treatment.
Dehydration
Canagliflozin can increase urination, which may lead to dehydration.
To help reduce this risk:
- Drink plenty of fluids unless your healthcare provider advises otherwise.
- Contact your healthcare provider if you experience prolonged vomiting or diarrhea.
Symptoms of dehydration may include:
- Dry mouth.
- Increased thirst.
- Dizziness or lightheadedness.
- Headache.
- Weakness.
Low Blood Sugar (Hypoglycemia)
Invokamet may increase the risk of low blood sugar, especially when taken with insulin or other diabetes medications that lower blood sugar.
Symptoms of low blood sugar may include:
- Shaking.
- Sweating.
- Hunger.
- Dizziness.
- Confusion.
- Fast heartbeat.
Talk to your healthcare provider about how to recognize and manage low blood sugar.
Risk of Lower Limb Amputation
Canagliflozin may increase the risk of lower limb amputation, particularly in people who have:
- A previous amputation.
- Foot ulcers or sores.
- Peripheral artery disease or poor circulation.
- Heart disease.
- Diabetic nerve damage (neuropathy).
Check your feet daily for cuts, sores, blisters, or signs of infection, and report any foot problems to your healthcare provider promptly.
Pregnancy
If you are pregnant, planning to become pregnant, or breastfeeding, tell your healthcare provider before taking Invokamet.
Invokamet is generally not recommended during pregnancy, particularly during the second and third trimesters. Your healthcare provider will discuss the potential benefits and risks and recommend the most appropriate treatment for managing your diabetes during pregnancy.
Regular Monitoring
While taking Invokamet, your healthcare provider may regularly monitor your:
- Blood sugar levels.
- Kidney function.
- Vitamin B12 levels (during long-term treatment).
- Overall response to therapy.
Keeping your follow-up appointments and monitoring your blood sugar regularly can help ensure the medication remains safe and effective.
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