Table of contents:
Indications
Dibenzyline, also known by its generic name phenoxybenzamine, is a medication used to treat high blood pressure and sweating in people with a certain type of tumor called pheochromocytoma. It belongs to a class of drugs called alpha blockers, which work by blocking certain receptors in the body, leading to a relaxation of the blood vessels and a decrease in blood pressure.
Phenoxybenzamine binds and inhibits alpha receptors, which play a role in the constriction of blood vessels and the increase in heart rate caused by adrenaline and other similar substances. By inhibiting alpha receptors, Phenoxybenzamine results in the dilation of blood vessels and the reduction of heart rate. This leads to a reduction in blood pressure. Overall, Phenoxybenzamine works by blocking the effects of certain natural substances in the body such as adrenaline.
Use and Dosage
Phenoxybenzamine is available in capsule form and should be taken orally with or without food as directed by a healthcare professional. Typically, it is taken 2 to 3 times per.
The recommended dosage of Phenoxybenzamine depends on the patient's medical condition and response to treatment and should be followed strictly. For example, for pheochromocytoma, the usual starting dose is 10 mg twice daily, which may be increased gradually under close supervision. Overall, the final dose is typically between 20 to 100 mg daily.
Take Phenoxybenzamine regularly and at the same time each day to get the most benefit from it. Even if you feel well, continue taking the medication as prescribed by your doctor. Suddenly stopping the medication may worsen your condition, so talk to your doctor before making any changes. If you experience increased blood pressure or any other concerns, let your doctor know.
Side Effects
Common Side Effects of Dibenzyline (Phenoxybenzamine):
- Blurred vision
- Drowsiness
- Mild dizziness
- Stuffy nose
- Tiredness
- Trouble having an orgasm
- Upset stomach
Serious Side Effects of Dibenzyline (Phenoxybenzamine):
- Difficulty breathing
- Hives
- Lightheadedness
- Severe dizziness
- Swelling of the face lips tongue or throat
Forms and Strength
Dibenzyline (Phenoxybenzamine) is available in the following forms and strength:
Phenoxybenzamine: Capsules
- 10 mg
Cautions
- Long-term use of phenoxybenzamine is not recommended due to the risk of developing certain types of cancer.
- Dibenzyline-induced alpha-adrenergic blockade leaves beta-adrenergic receptors unopposed. Compounds that stimulate both types of receptors may produce an exaggerated hypotensive effect.
- Phenoxybenzamine may interact with other medications, discuss any current medications with a healthcare professional before starting treatment with this medication.
- Phenoxybenzamine may cause side effects such as dizziness, fatigue, and nausea, follow the dosage instructions provided by a healthcare professional when taking this medication.
- Dibenzyline may worsen respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD) or asthma, so patients with these conditions should be closely monitored while taking this medication.
- Dibenzyline should be used with caution in patients with liver or kidney disease, as the drug may not be as well tolerated in these patients.
- Dibenzyline may cause priapism (an erection that lasts for hours and is not related to sexual stimulation) in some patients, particularly those with sickle cell anemia or a history of priapism.
- Phenoxybenzamine may interfere with the body's ability to regulate temperature, making patients more sensitive to heat or cold.
- Dibenzyline may cause postural hypotension (a drop in blood pressure when standing up from a sitting or lying position), particularly in patients who are dehydrated.
- Phenoxybenzamine may cause drowsiness or dizziness, which may impair the patient's ability to perform certain tasks, such as driving or operating machinery.
- Dibenzyline should be used with caution in patients with a history of congestive heart failure or other cardiovascular diseases, as it may exacerbate these conditions.
- Phenoxybenzamine may worsen symptoms of depression or bipolar disorder in some patients
Frequently Asked Questions (FAQ)
How long does it take for Dibenzyline to start working?
The time it takes for Dibenzyline to start working can vary depending on the individual and the condition being treated. It may take several days or even weeks for the full effects of the medication to be felt.
Can Dibenzyline be used to treat high blood pressure in people without pheochromocytoma?
Dibenzyline is typically only used to treat high blood pressure in people with pheochromocytoma. It is not commonly used as a first-line treatment for hypertension in other individuals.
How often do I need to take Dibenzyline?
The frequency of Dibenzyline dosing will depend on the individual and the condition being treated. Typically, the medication is taken one to three times per day, but this may be adjusted by a healthcare professional based on the individual's response to treatment.
Can Dibenzyline be used in children?
The use of Dibenzyline in children has not been extensively studied. It should only be used in children under the guidance and supervision of a healthcare professional.
Can Dibenzyline cause addiction or dependence?
Dibenzyline is not known to cause addiction or dependence, but sudden withdrawal from the medication may lead to a rapid increase in blood pressure. Patients should always talk to their doctor before discontinuing use of the medication.
Resources
It's important to purchase Dibenzyline from verified Canadian pharmacy.
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