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Dantrium (active ingredient: dantrolene sodium) is a prescription skeletal muscle relaxant used to treat certain conditions that cause severe muscle tightness, stiffness, or abnormal muscle contractions.
Dantrium works directly on skeletal muscle rather than mainly through the brain or spinal cord. It reduces the amount of calcium released inside muscle cells, which decreases the strength of muscle contractions.
Chronic Spasticity
Dantrium capsules are used to control chronic spasticity caused by certain upper motor neuron disorders. Spasticity causes muscles to become unusually tight or stiff and can interfere with movement, positioning, comfort, and daily activities.
Conditions that may cause this type of spasticity include:
Dantrium may be particularly useful when reducing muscle tightness can improve movement, rehabilitation, positioning, or daily function.
Spinal Cord Injury
Damage to the spinal cord can interrupt normal signals between the brain and muscles. This may lead to muscle stiffness, spasms, and exaggerated reflexes.
Dantrium can reduce excessive muscle contraction and may make movement, stretching, physical therapy, and daily activities easier for some patients.
Spasticity After a Stroke
A stroke can damage areas of the brain involved in controlling movement. Some people develop increased muscle tone and stiffness in an arm, leg, or other part of the body.
Dantrium may help reduce this excessive muscle activity when the healthcare provider determines that reducing spasticity is likely to improve function.
Cerebral Palsy
Cerebral palsy can cause persistent muscle tightness and abnormal muscle tone.
Dantrium may be used in selected patients when muscle spasticity interferes with movement, positioning, rehabilitation, or everyday activities.
Multiple Sclerosis
Multiple sclerosis can interfere with nerve signals that control muscles, sometimes causing painful spasms, stiffness, and difficulty moving.
Dantrium can help reduce excessive muscle contraction associated with this type of spasticity.
Malignant Hyperthermia
Dantrolene is also an important treatment for malignant hyperthermia, a rare but life-threatening reaction that can occur in susceptible people exposed to certain general anesthetic agents or succinylcholine.
Malignant hyperthermia can cause rapidly increasing body temperature, severe muscle rigidity, increased carbon dioxide production, fast heart rate, and dangerous metabolic changes.
Intravenous Dantrium is used to treat an active malignant hyperthermia crisis.
Prevention of Malignant Hyperthermia
Oral dantrolene may also be used before surgery in people who are known or strongly suspected to be susceptible to malignant hyperthermia. It can also be given after a malignant hyperthermia episode to help prevent symptoms from returning.
Dantrium is different from many other muscle relaxants because it acts directly on skeletal muscle.
Reduces Calcium Release Inside Muscle Cells
Muscles need calcium to contract.
When a muscle receives a signal to contract, calcium is released from a storage area inside the muscle cell called the sarcoplasmic reticulum.
Dantrolene interferes with this calcium-release process. With less calcium available inside the muscle cell, the muscle cannot contract as strongly.
Reduces Muscle Tightness and Spasms
By decreasing the strength of skeletal muscle contractions, Dantrium can reduce:
For people with chronic spasticity, this may help make movement and rehabilitation easier when excessive muscle tone is limiting function.
Helps Control Malignant Hyperthermia
During malignant hyperthermia, abnormal calcium release inside skeletal muscle causes uncontrolled muscle activity and a rapid increase in metabolism.
Intravenous dantrolene reduces calcium release in skeletal muscle, helping control muscle rigidity and the dangerous metabolic reaction associated with malignant hyperthermia.
Dantrium is specifically used for spasticity associated with upper motor neuron disorders and for malignant hyperthermia-related treatment or prevention.
It is not intended to treat ordinary muscle soreness, minor muscle strains, or every type of muscle spasm.
In some people, a certain amount of muscle stiffness helps them stand, maintain posture, balance, or transfer from one position to another.
For this reason, Dantrium should not be used when reducing spasticity would interfere with the person’s ability to maintain important physical functions. This is specifically listed as a contraindication in oral dantrolene prescribing information.
Dantrium can be effective for chronic spasticity and is an important medication for malignant hyperthermia, but the oral and intravenous formulations have different uses.
Oral Dantrium is primarily used for chronic spasticity and may be used around malignant hyperthermia episodes, while intravenous Dantrium is used for the emergency treatment of malignant hyperthermia.
Use Dantrium only under the direction of a healthcare provider because treatment must be individualized and the medication can cause serious side effects, including liver injury with oral therapy.
Dantrium capsules are taken by mouth. The dose depends on the condition being treated and your response to treatment.
Take Dantrium exactly as directed by your healthcare provider. Do not take a larger dose, take it more often, or continue treatment longer than prescribed.
Because oral dantrolene can cause serious liver injury, treatment should be used with appropriate medical supervision and liver-function monitoring.
For adults with chronic spasticity, Dantrium is usually started at a low dose and increased gradually. This allows your healthcare provider to find the lowest dose that provides enough benefit while limiting side effects.
A typical adult dosing schedule is:
Some people may require four doses per day. However, doses greater than 100 mg four times daily should not be used.
The goal of treatment is not necessarily to remove all muscle tone.
Your healthcare provider will adjust the dose based on how much Dantrium improves movement, comfort, rehabilitation, or daily activities. Too much muscle relaxation can cause weakness and may interfere with standing, walking, or other physical functions.
The lowest dose that provides a meaningful benefit should generally be used.
Do not increase your dose on your own.
Dantrolene is gradually increased because side effects such as muscle weakness, tiredness, dizziness, and drowsiness may become more noticeable at higher doses. Slow dose adjustment also helps your healthcare provider determine whether the medication is actually improving your spasticity.
For chronic spasticity, the prescribing information recommends stopping treatment if there is no noticeable benefit after a total of about 45 days of therapy.
Your healthcare provider should decide whether to continue, reduce, or discontinue treatment based on your response.
Dantrolene is also used for malignant hyperthermia, but it is important to distinguish between oral Dantrium capsules and intravenous Dantrium.
They have different dosing schedules and are used in different situations.
For someone known or suspected to be susceptible to malignant hyperthermia, oral dantrolene may be prescribed before surgery.
The labeled oral regimen is 4 to 8 mg/kg per day, divided into three or four doses, for 1 or 2 days before surgery. The final dose is generally taken about 3 to 4 hours before the scheduled procedure with a small amount of water.
This treatment should be managed by a healthcare provider familiar with malignant hyperthermia.
An active malignant hyperthermia emergency is treated with intravenous dantrolene, not oral capsules.
Intravenous dosing is weight-based and is administered by healthcare professionals in a medical setting. The exact dose depends on the patient’s condition and response to emergency treatment.
Intravenous Dantrium may also be used as prophylaxis in people who are susceptible to malignant hyperthermia.
The labeled prophylactic dose is 2.5 mg/kg, beginning approximately 1¼ hours before anesthesia and infused over about 1 hour.
This should not be confused with the oral preoperative regimen.
Oral dantrolene may be given after a malignant hyperthermia episode to help prevent symptoms from returning. The dose and duration are determined by the treating healthcare team.
If you take Dantrium several times a day for chronic spasticity, take the doses at approximately the same times each day.
A consistent schedule helps maintain a more stable amount of medication in your body and makes missed doses less likely.
Do not increase, decrease, or stop Dantrium without speaking with your healthcare provider.
Your dose may need to be adjusted if you develop excessive muscle weakness, drowsiness, dizziness, or other side effects.
Oral dantrolene carries a significant risk of liver injury. Liver problems can sometimes be severe or fatal.
Your healthcare provider may order blood tests before treatment and periodically during therapy to monitor your liver function.
Contact your healthcare provider promptly if you develop possible symptoms of liver injury, such as:
The original text combines oral and intravenous malignant hyperthermia dosing.
For clarity, oral Dantrium capsules used before surgery are dosed at 4 to 8 mg/kg per day in three or four divided doses for 1 to 2 days before surgery.
The 2.5 mg/kg dose refers to intravenous dantrolene used in specific malignant-hyperthermia settings, not the standard oral capsule dose for chronic spasticity.
Take Dantrium exactly as prescribed. For chronic spasticity, treatment usually begins with 25 mg once daily and is increased gradually until the lowest effective dose is reached. Do not exceed the prescribed dose, and keep all appointments for liver-function monitoring while taking oral dantrolene.
Dantrium (Dantrolene) is available in the following forms and strength:
Take Dantrium only for the condition your healthcare provider prescribed it to treat.
Do not use leftover Dantrium for another medical problem unless your healthcare provider specifically tells you to do so. Oral dantrolene can cause serious side effects, including liver injury, so treatment should be carefully supervised.
Do not give Dantrium to another person, even if they have similar symptoms or the same medical condition.
The appropriate dose depends on the condition being treated, the person’s response, and their individual medical history.
Dantrium commonly causes drowsiness, dizziness, weakness, fatigue, and a general feeling of being unwell, especially when treatment is first started or the dose is increased.
These effects may reduce your ability to concentrate, react quickly, or perform physical activities safely.
Avoid driving, operating machinery, or doing other potentially dangerous activities until you know how Dantrium affects you.
If you feel sleepy, dizzy, weak, or less alert than usual, do not drive or perform activities that require coordination or quick reactions.
Alcohol and medicines that cause drowsiness may make Dantrium’s sedating effects stronger.
Talk to your healthcare provider before drinking alcohol or using medicines for anxiety, sleep, pain, or other conditions that may cause drowsiness. Combining these substances may make dizziness, weakness, or impaired alertness worse.
Because Dantrium reduces skeletal muscle contractions, it can cause or worsen muscle weakness.
Tell your healthcare provider if weakness becomes severe or interferes with walking, standing, breathing, swallowing, or normal daily activities. Muscle weakness is among the commonly reported adverse effects of dantrolene.
Oral Dantrium can cause serious liver injury. People with active liver disease, such as hepatitis or cirrhosis, should not use oral Dantrium.
Your healthcare provider may order liver-function tests before and during treatment. Contact your healthcare provider promptly if you develop symptoms such as persistent nausea, loss of appetite, unusual tiredness, dark urine, abdominal discomfort, or yellowing of the skin or eyes.
Dantrium should not be used when muscle spasticity is needed to help a person maintain upright posture, balance, or useful physical function.
Reducing that muscle tone could make standing, walking, transfers, or other activities more difficult. This is listed as a contraindication for oral Dantrium.
Some product information has reported increased sensitivity to sunlight during dantrolene treatment.
If you notice that your skin burns or reacts to sunlight more easily than usual, limit unnecessary sun exposure, wear protective clothing, and use appropriate sun protection. Contact your healthcare provider if you develop severe redness, swelling, blistering, or another significant skin reaction.
Do not take Dantrium if you have had a serious allergic reaction to dantrolene sodium or another ingredient in your specific product.
Seek urgent medical attention if you develop difficulty breathing, severe swelling, hives, or another serious allergic reaction.
Take Dantrium exactly as prescribed and do not change the dose on your own. Because it can cause drowsiness, dizziness, muscle weakness, and serious liver injury, regular medical monitoring may be needed during oral treatment.
Dantrium is a skeletal muscle relaxant that works directly on the muscles. It reduces the release of calcium inside skeletal muscle cells, which decreases the strength of muscle contractions. For people with chronic spasticity, this can help reduce muscle stiffness, spasms, and excessive muscle tone. Dantrolene does not cure the underlying neurological condition, but reducing spasticity may make movement, daily activities, or physical therapy easier. Dantrium is also used for malignant hyperthermia. In this life-threatening condition, excessive calcium release causes severe muscle activity and a dangerous increase in metabolism. Intravenous dantrolene helps control this reaction by reducing calcium release in skeletal muscle.
No. Dantrium is not appropriate for everyone and should be used only under the supervision of a healthcare provider. Oral dantrolene can cause serious liver injury, including hepatitis. Because of this risk, your healthcare provider may perform liver-function tests before and during treatment. Dantrium should only be used for conditions in which its potential benefits justify the risks. Before starting Dantrium, tell your healthcare provider about all of your medical conditions and all prescription medicines, over-the-counter drugs, vitamins, and supplements you take. Your healthcare provider can determine whether Dantrium is appropriate for you and whether additional monitoring is needed.
Dantrolene is available in oral and intravenous forms, and each form is used for different purposes. Oral Dantrium capsules are commonly used to manage chronic spasticity. Oral dantrolene may also be used before surgery in people who are susceptible to malignant hyperthermia. The oral dose is individualized and usually increased gradually until the lowest effective dose is found. Intravenous Dantrium is primarily used in a medical setting to treat an active malignant hyperthermia emergency. It is given directly into a vein by healthcare professionals and is dosed according to body weight and the patient’s response.
If you miss a dose of oral Dantrium, follow the instructions provided by your healthcare provider or pharmacist. In general, take the missed dose when you remember unless it is almost time for your next scheduled dose. If the next dose is close, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time or take extra medicine to make up for a missed dose.
Do not stop or change your Dantrium treatment without first talking to your healthcare provider. For chronic spasticity, your healthcare provider will regularly assess whether the medicine is providing a meaningful benefit. Because long-term oral dantrolene can damage the liver, prescribing information recommends discontinuing treatment if there is no noticeable benefit within about 45 days.
Oral dantrolene can cause liver injury, and the risk increases with certain doses and longer treatment. Your healthcare provider may order blood tests to check how well your liver is working before and during treatment. Contact your healthcare provider promptly if you develop unusual tiredness, loss of appetite, persistent nausea, abdominal discomfort, dark urine, or yellowing of the skin or eyes.
| Generic name: | Dantrolene |
|---|---|
| Formulation: | Capsule |
| Strength(s): | 25mg, 50mg, 100mg |
| Quantities Available: | 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Dantrium (dantrolene) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Dantrium is commonly prescribed in dosages of 25 mg, 50 mg, or 100 mg, taken in divided doses throughout the day. The quantity you would order will depend on the specific dosage prescribed by your healthcare provider.
For example: If you were prescribed a typical dose of 100 mg four times daily, then for a 90-day supply, you would order 360 capsules of 100 mg (90 days x 4 capsules per day).
No, we do not sell dantrolene directly. However, you can still enjoy low prices on Dantrium, which contains dantrolene as an active ingredient. You will need a valid prescription from your healthcare provider. We require this to dispense the medication. You can mail, fax, or upload your prescription through your online account.
Yes, we ship Dantrium (dantrolene) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Dantrium (Dantrolene). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Dantrium (Dantrolene).
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