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Crinone Gel (Progesterone) Shopper Approved

Prescription Prescription Required FormationFormulation: Gel

Crinone Gel

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Prescription Prescription Required FormationFormulation: Gel

Progesterone

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Crinone Gel (progesterone) is a prescription vaginal gel used to support pregnancy in women who need additional progesterone. Progesterone is a natural hormone that helps prepare the lining of your uterus (womb) for pregnancy and supports the early stages of pregnancy.

Your doctor may prescribe Crinone Gel if your body does not produce enough progesterone or if you are receiving fertility treatments, such as in vitro fertilization (IVF).

Crinone Gel is commonly used for the following conditions:

  • Luteal Phase Support During Fertility Treatment: Crinone Gel helps support the early stages of pregnancy in women undergoing assisted reproductive technology (ART), including IVF. During fertility treatment, your body may not produce enough progesterone to prepare and maintain the lining of your uterus. Crinone Gel provides additional progesterone to help create a suitable environment for a fertilized egg to attach to the uterine lining and develop.
  • Progesterone Deficiency: Crinone Gel may be prescribed to women who do not produce enough progesterone during the second half of their menstrual cycle, known as the luteal phase. Low progesterone levels can make it harder for the uterine lining to support a pregnancy. Crinone Gel helps replace the missing progesterone and supports the changes in the uterus needed for pregnancy.

Crinone Gel does not guarantee pregnancy, but it can help provide the hormone support your body needs during certain fertility treatments. Your doctor will decide whether this medication is right for you based on your hormone levels, medical history, and treatment plan.

How Does Crinone Gel Work?

Crinone Gel contains progesterone, a hormone that plays an important role in your menstrual cycle and pregnancy.

After ovulation, your body normally produces progesterone to prepare the lining of your uterus for a possible pregnancy. This hormone helps make the uterine lining thick and supportive so a fertilized egg can attach and begin to grow.

If your body does not produce enough progesterone, the uterine lining may not be able to support the early stages of pregnancy properly.

Crinone Gel works by providing additional progesterone directly through your vagina. The medication is absorbed through the vaginal tissues and helps maintain the uterine lining during fertility treatment.

By increasing progesterone support, Crinone Gel helps:

  • Prepare the Uterine Lining: Progesterone helps create an environment where a fertilized egg can attach to the uterus.
  • Support Early Pregnancy: It helps maintain the uterine lining during the early stages of pregnancy.
  • Replace Low Progesterone Levels: It provides additional hormone support when your body does not make enough progesterone naturally.

Crinone Gel belongs to a group of medications called progestins. Its active ingredient is progesterone, which is the same hormone your body naturally produces.

Because Crinone Gel is applied vaginally, it delivers progesterone through the vaginal tissues. Follow your doctor’s instructions carefully and continue using the medication for as long as prescribed, especially if you are receiving fertility treatment.

Crinone Gel may also be used to treat secondary amenorrhea, a condition where menstrual periods stop in someone who previously had them. The 4% gel is used for this purpose, while the 8% gel may be prescribed if the 4% strength does not work. The 8% gel is also used during fertility treatment. 

Always use the strength and dose prescribed by your doctor, as treatment depends on your specific condition.

Crinone Gel (progesterone) is a prescription vaginal gel used to provide extra progesterone during fertility treatment or to help manage certain menstrual problems. It comes in a prefilled, single-use applicator that allows you to place the medication directly into your vagina.

Your doctor will tell you how much Crinone Gel to use, how often to apply it, and how long to continue treatment. Your dose will depend on your medical condition and how your body responds to the medication.

Always follow your doctor’s instructions carefully. Do not use more or less medication than prescribed, and do not stop treatment without speaking to your doctor.

Recommended Dosage of Crinone Gel

For Fertility Treatment

If you are using Crinone Gel as part of fertility treatment, such as in vitro fertilization (IVF), your doctor will usually recommend applying the gel once or twice a day. The medication helps maintain the lining of your uterus and provides the progesterone support needed during the early stages of pregnancy.

If you become pregnant, your doctor may recommend continuing treatment for up to 10 to 12 weeks, depending on your fertility treatment plan. Do not stop using Crinone Gel on your own, even if you receive a positive pregnancy test.

For Menstrual Cycle Problems

If you are using Crinone Gel to treat secondary amenorrhea (the absence of menstrual periods), your doctor may recommend applying the gel every other day for a total of six doses.

This treatment helps provide progesterone to your body and may help bring on menstrual bleeding after the treatment is completed. Follow your doctor’s instructions carefully, as your dose and treatment schedule may depend on your condition.

How to Apply Crinone Gel

Crinone Gel comes in a sealed, prefilled applicator designed for vaginal use. Each applicator contains one dose of medication.

Follow these steps to apply the gel correctly:

  1. Wash your hands: Clean your hands with soap and water before handling the medication.
  2. Remove the applicator: Take the applicator out of its sealed wrapper. Make sure the packaging is not damaged before use.
  3. Prepare the applicator: Hold the applicator by its thick end and shake it downward as directed in the package instructions. This helps move the gel toward the narrow tip. Twist off the tab at the narrow end without squeezing the air chamber.
  4. Find a comfortable position: You can apply the gel while sitting, standing, or lying down. Choose a position that allows you to insert the applicator comfortably.
  5. Insert the applicator: Gently place the narrow end of the applicator into your vagina. Insert it only as far as feels comfortable. Do not force it.
  6. Apply the gel: Firmly squeeze the air chamber at the thick end of the applicator to release the medication into your vagina.
  7. Remove the applicator: Keep the air chamber squeezed while gently removing the applicator. Some gel may remain inside the applicator after use. This is normal, and you should still receive the intended dose.
  8. Throw away the applicator: Each applicator is designed for one use only. Dispose of it after applying the medication. Do not reuse it.
  9. Wash your hands again: Clean your hands after applying the gel.

Important Tips When Using Crinone Gel

  • Follow your prescribed schedule: Use Crinone Gel at the same time each day or on the days recommended by your doctor. This helps maintain consistent progesterone support.
  • Avoid using other vaginal products at the same time: If you need to use other vaginal medications or products, ask your doctor first. You may be advised to separate their use from Crinone Gel by at least six hours.
  • Do not use extra medication: Applying more gel than prescribed will not make your treatment work faster or improve your chances of pregnancy. It may increase your risk of side effects.
  • Continue treatment as directed: If you are receiving fertility treatment, do not stop using Crinone Gel without speaking to your fertility specialist, even if you feel well or have a positive pregnancy test.
  • Expect some vaginal discharge: You may notice white or clumpy discharge while using Crinone Gel. This can happen because the gel is designed to stay in your vagina and release progesterone gradually. Contact your doctor if you develop a strong odor, itching, burning, or unusual discharge.
  • Use only the provided applicator: Do not try to apply the gel with your fingers or transfer it to another container. The prefilled applicator is designed to deliver the correct dose.

Special Instructions for High Altitudes

If you are using Crinone Gel at an altitude above 2,500 feet (762 meters), changes in air pressure may affect the applicator. You may need to remove trapped air before applying the medication.

Follow the special high-altitude instructions included in your medication package or ask your pharmacist to show you how to prepare the applicator correctly. This helps make sure you receive the intended dose.

Important: Crinone Gel is available in different strengths, and the dose depends on why you are using it. For fertility treatment, the 8% gel is commonly used once daily or twice daily in certain cases. For menstrual problems, the 4% gel is commonly used every other day for six doses. Always follow your prescribed treatment plan. 

Common Side Effects of Crinone Gel (Progesterone):

  • Bloating
  • Breast swelling or tenderness
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Headache
  • Increased night-time urination
  • Joint or muscle pain
  • Loss of interest in sex
  • Nausea
  • Pain during intercourse
  • Pain in your vaginal or rectal area
  • Stomach cramps
  • Stomach pain
  • Tired feeling
  • Vaginal burning
  • Vaginal discharge
  • Vaginal itching
  • Vomiting

Serious Side Effects of Crinone Gel (Progesterone):

  • Breast lump
  • Chest pain or heavy feeling 
  • Pain spreading to the arm or shoulder
  • Clay-colored stools
  • Coughing up blood
  • Dark urine
  • Fever, chills, body aches, flu symptoms
  • Itching
  • Loss of appetite
  • Nausea
  • Pain behind your eyes
  • Pain or burning when you urinate
  • Pain spreading to your jaw or shoulder
  • Pain, swelling, warmth, and redness in one or both legs
  • Problems with speech or balance
  • Rapid breathing
  • Severe headache
  • Shortness of breath or problems with vision, speech, or balance
  • Slurred speech
  • Stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)
  • Sudden cough
  • Sudden headache, numbness, or weakness (especially on one side of the body)
  • Sudden severe headache
  • Sudden vision changes
  • Sweating
  • Swelling in your hands, ankles, or feet
  • Symptoms of depression (sleep problems, weakness, mood changes)

Crinone Gel (Progesterone) is available in the following forms and strength:

Crinone Gel: Gel

  • 8%

Before using Crinone Gel (progesterone), tell your doctor about any medical conditions, allergies, or medications you are taking. Although Crinone Gel can help support fertility treatment and manage certain menstrual problems, it may not be suitable for everyone. Understanding these warnings and precautions can help you use the medication safely.

Allergic Reactions

Do not use Crinone Gel if you are allergic to progesterone or any other ingredient in the medication. An allergic reaction may cause itching, a skin rash, redness, or swelling. In rare cases, a severe allergic reaction may cause difficulty breathing or swelling of your face, lips, or throat. Stop using the medication and seek emergency medical care if you experience these serious symptoms.

Liver Problems

Do not use Crinone Gel if you have active liver disease or serious liver problems. Your liver helps process hormones, including progesterone. If your liver is not working properly, the medication may build up in your body and increase your risk of side effects. Tell your doctor if you have a history of liver disease, hepatitis, or abnormal liver function tests before starting treatment.

Blood Clots and Circulation Problems

Crinone Gel may not be suitable for people who have a history of blood clots or certain circulation problems. Do not use this medication if you have an active blood clot or a history of serious blood clotting conditions unless your specialist has assessed the risks and determined an appropriate treatment. Seek immediate medical attention if you develop sudden chest pain, trouble breathing, swelling or pain in one leg, or sudden weakness on one side of your body.

Breast Cancer and Other Hormone-Sensitive Conditions

Tell your doctor if you have or have ever had breast cancer or another hormone-sensitive cancer. Progesterone can affect certain tissues that respond to hormones. Crinone Gel should not be used if you have known or suspected breast cancer or certain other hormone-sensitive cancers. Your doctor will review your medical history to determine whether this medication is safe for you.

Asthma, Epilepsy, and Heart Problems

If you have asthma, epilepsy, heart disease, or kidney problems, tell your doctor before using Crinone Gel. Progesterone may affect fluid balance and could make certain health conditions worse. Your doctor may recommend closer monitoring during treatment, especially if you have problems with fluid retention, seizures, or heart function.

Drug Interactions

Crinone Gel may interact with certain medications or other vaginal treatments. Before starting treatment, tell your doctor or pharmacist about all the medications you take, including prescription drugs, over-the-counter medications, herbal products, and supplements. Some medications may affect how progesterone works or increase your risk of side effects. Do not start any new medication or vaginal treatment without checking with your healthcare provider.

Vaginal Irritation and Discharge

Crinone Gel may cause mild vaginal irritation, itching, burning, or discharge. You may also notice white or clumpy discharge because some of the gel can remain in your vagina after the progesterone has been released. This is usually normal. However, contact your doctor if you develop severe irritation, unusual vaginal bleeding, a strong odor, or discharge accompanied by pain or itching.

Headaches and Breast Tenderness

Some people may experience headaches, breast tenderness, bloating, or mild stomach discomfort while using Crinone Gel. These effects can occur because progesterone changes the way your body responds to hormones. They are usually mild, but you should tell your doctor if they become severe or do not go away.

Dizziness and Drowsiness

Crinone Gel may cause dizziness, tiredness, or drowsiness in some people. These effects may make it harder to concentrate or perform activities that require alertness. Avoid driving, operating machinery, or doing potentially dangerous tasks until you know how the medication affects you. If you feel unusually sleepy or dizzy, contact your doctor for advice.

Pregnancy and Breastfeeding

Crinone Gel is often prescribed during fertility treatment to help support the early stages of pregnancy. If you become pregnant while using this medication, continue treatment only as directed by your fertility specialist. Do not stop using the gel without speaking to your doctor.

If you are breastfeeding, tell your doctor before using Crinone Gel. Progesterone can pass into breast milk, and your doctor will help you decide whether treatment is appropriate.

Proper Dosage and Length of Treatment

Use Crinone Gel exactly as prescribed by your doctor. Your dose and treatment schedule will depend on whether you are receiving fertility treatment or managing a menstrual condition. Do not apply more gel than recommended or use it more often than prescribed. Using extra medication will not improve your treatment results and may increase your risk of side effects. If you miss a dose or are unsure about your treatment schedule, contact your doctor or pharmacist for guidance.

Laboratory Tests

Crinone Gel may affect the results of certain laboratory tests, including hormone tests and some thyroid or liver function tests. Before having blood work or other medical tests, tell your doctor that you are using progesterone. This will help your healthcare provider interpret your results correctly and decide whether any additional testing is needed.

Unusual Vaginal Bleeding

Tell your doctor if you experience unexplained vaginal bleeding before starting Crinone Gel. Bleeding can have several causes, and your doctor may need to examine you before recommending treatment. If you develop heavy bleeding, severe pelvic pain, or unusual bleeding while using Crinone Gel, contact your doctor promptly.

When to Contact Your Doctor

Contact your doctor if you experience severe vaginal irritation, unusual bleeding, persistent headaches, worsening dizziness, or other symptoms that concern you while using Crinone Gel.

Seek emergency medical attention if you develop sudden chest pain, difficulty breathing, severe leg swelling, sudden vision changes, or weakness on one side of your body. These may be signs of a serious medical problem, such as a blood clot.

Always follow your doctor’s instructions and attend any recommended follow-up appointments. If you are receiving fertility treatment, regular monitoring can help your doctor check your progress and determine how long you need progesterone support.

Can I have sex while using Crinone Gel?

You may be able to have sex while using Crinone Gel, but it is important to check with your doctor first. If you are receiving fertility treatment, such as in vitro fertilization (IVF), your doctor may recommend avoiding sexual activity during certain stages of your treatment. It is generally best to avoid sexual activity immediately after applying the gel to give the medication time to stay in place. Your doctor can advise you on the best timing for sexual activity based on your treatment plan. If you experience vaginal irritation, discomfort, or unusual bleeding, contact your doctor before having sex.

How should I store Crinone Gel?

Store Crinone Gel at room temperature, usually between 15°C and 25°C (59°F and 77°F), or as directed on the product packaging. Keep the medication away from direct sunlight, excessive heat, and moisture. Do not freeze the gel, as this may affect its quality. Keep each applicator in its original sealed wrapper until you are ready to use it. Do not use the medication if the packaging is damaged or the expiration date has passed. Always store Crinone Gel out of the reach of children and pets. Ask your pharmacist how to safely dispose of any expired or unused medication.

Can I exercise while using Crinone Gel?

You can usually continue light physical activities, such as walking and gentle stretching, while using Crinone Gel. However, your doctor may recommend avoiding strenuous exercise, heavy lifting, or activities that put pressure on your abdomen, especially if you are undergoing fertility treatment. Exercise recommendations depend on your health, fertility treatment stage, and how your body responds to medication. If you experience abdominal pain, dizziness, unusual bleeding, or discomfort during exercise, stop the activity and contact your doctor. Always follow your fertility specialist’s advice about which activities are safe for you.

Can Crinone Gel be used for conditions other than fertility treatment?

Yes. Although Crinone Gel is commonly used during assisted reproductive technology (ART) treatments, such as IVF, it may also be prescribed for certain menstrual problems. For example, Crinone Gel may be used to treat secondary amenorrhea, a condition where menstrual periods stop in someone who previously had regular periods. In this case, the medication provides progesterone to help manage the menstrual cycle and may help bring on menstrual bleeding after treatment. Your doctor will decide whether Crinone Gel is suitable for your condition and recommend the appropriate strength, dose, and treatment schedule. Do not use this medication for other conditions unless your doctor has prescribed it specifically for you.

REVIEWS

Additional Information Book
Generic name:

Progesterone

Formulation:

Gel

Strength(s):

8%

Quantities Available:

18app, 36app

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Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Crinone Gel can I order at once from a Canadian pharmacy?

When ordering Crinone Gel (progesterone) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Crinone Gel is commonly applied intravaginally once or twice daily. For a 90-day supply, if using 1 applicator per day, you would order 90 applicators (90 days x 1 applicator per day). If using 2 applicators per day, you would order 180 applicators (90 days x 2 applicators per day).

Do you sell progesterone?

No, we do not sell progesterone directly on our website. However, you can still enjoy low prices on Crinone Gel, which contains progesterone as an active ingredient. To purchase Crinone Gel, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Crinone Gel (progesterone) to the United States?

Yes, we ship Crinone Gel (progesterone) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Crinone Gel (Progesterone). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Crinone Gel (Progesterone).