Creon 25 (Pancreatic enzyme) Shopper Approved

Prescription Prescription Required FormationFormulation: DR Capsule

Creon 25

(Brand Option)

Select the prescribed dosage

Prescription Prescription Required FormationFormulation: DR Capsule

Pancreatic enzyme

We don't sell this generic-version medication.

Select the quantity to see the price.


We don't charge dispensing fee


Shipped and delivered directly to your doorstep


Creon is a prescription medication used to aid digestion in people who have a condition called exocrine pancreatic insufficiency (EPI). EPI occurs when the pancreas is unable to produce enough digestive enzymes to break down food in the small intestine.

Creon helps people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some, or all, of the pancreas (pancreatectomy), or other conditions.

Creon contains a combination of three enzymes: lipase, protease, and amylase, which help to break down fats, proteins, and carbohydrates, respectively. It is a delayed-release pancreatic enzyme replacement therapy (PERT) that works by replacing the three main pancreatic enzymes that are normally made by a healthy pancreas.

Use and Dosage

Creon 25 is available in capsule form and should be taken by mouth with meals and snacks as directed by your doctor. The capsule should be swallowed whole, without crushing or chewing it, and should not be kept in the mouth to avoid irritation.

If swallowing is difficult, the capsule may be opened and the contents mixed with a small amount of soft food or liquid that does not require chewing, such as room-temperature applesauce. However, avoid mixing the contents with alkaline foods or liquids such as milk, ice cream, or tea, and consult your doctor or pharmacist for a list of foods to avoid. Swallow the mixture immediately without chewing and drink a glass of water or juice to ensure it is swallowed completely. Do not store the medication mixture for later.

Dosage of Creon 25 is based on your medical condition, diet, weight, and response to treatment, and you should not take more capsules in a day than prescribed by your doctor. Drinking plenty of fluids while taking Creon 25 capsules is encouraged, unless otherwise instructed by your doctor.

For the medication to be most effective, use it regularly with every meal or snack recommended by your doctor. If you are following a special diet as advised by your doctor, comply with the diet to achieve the maximum benefit from the medication.

Side Effects

Common Side Effects of Creon 25 (Pancreatic enzyme):

  • Bloating
  • Constipation
  • Cough
  • Diarrhea
  • Dizziness
  • Gas
  • Greasy stools
  • Headache
  • Nausea
  • Rectal irritation
  • Stomach pain or upset
  • Vomiting
  • Weight loss

Serious Side Effects of Creon 25 (Pancreatic enzyme):

  • Frequent or painful urination
  • Joint pain
  • Severe constipation
  • Severe stomach or abdominal discomfort
  • Worsening gout
  • Painful or swollen joints

Forms and Strength

Creon 25 (Pancreatic enzyme) is available in the following forms and strength:

Creon 25: Capsule

  • 300 mg
  • 25000/25500/1600 units


  • Allergic reactions, including anaphylaxis, have been reported in patients taking Creon 25.
  • Caution should be exercised when using the medication in patients with a history of allergies or hypersensitivity to pork products.
  • Creon 25 is not recommended for use in patients who are allergic to pork.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. Tell your doctor if you have a history of intestinal blockage or scarring or thickening of your bowel wall (fibrosing colonopathy). The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or their contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Potential for interactions with other medications.
  • Risk of viral transmission with all pancreatic enzyme products, including Creon.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions, including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • Use with caution in patients with a history of esophageal varices.
  • Use with caution in patients with a history of high uric acid levels.
  • Use it with caution in patients with a history of intestinal blockage or bowel obstruction.
  • Use with caution in patients with a history of liver or kidney disease.
  • Use with caution in patients with gout or hyperuricemia.

Frequently Asked Questions (FAQ)

How do I take Creon 25?

Creon 25 should be taken with food, as directed by your doctor. The dose and timing of Creon 25 may depend on the severity of your condition and the types of food you are eating.

Can I take other medications with Creon 25?

Tell your doctor about all medications you are taking, as certain medications may interact with Creon 25. This includes antacids and proton pump inhibitors.

Can I drink alcohol while taking Creon 25?

Avoid alcohol while taking Creon 25, as it may interfere with the medication's effectiveness and cause unpleasant side effects.


Additional information

Generic name:

Pancreatic enzyme


DR Capsule, Delayed Release Capsule


300mg, 25000/25500/1600 units

Quantities Available:

100, 200, 300, 600


Additional Information Book

If you have any Questions

Call Us

call us toll free


OR Email us at

[email protected]

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies. widget logo

Ordering Creon 25 just became easier

Discover Our Users' Stories!

Watch how Online Pharmacies Canada is helping customers save money on their medications.

Learn how Online Pharmacies Canada is helping customers save money on their medications.

Learn more about who we are

Generic vs Brand Name Drugs: Is There a Difference?

Generic vs Brand Name Drugs: Is There a Difference?

Many people want to know the difference between generic and brand-name drugs, especially when it comes to their health and their wallets. Knowing what sets these medications apart can help…

CIPA Certified Pharmacies Recognized as Safe in the US

Why does Canadian pharmacy require a prescription?

A medical prescription (often abbreviated as Rx) is a formal written order issued by a licensed healthcare professional, such as a physician, nurse practitioner, or dentist. This order authorizes a…

Affordable medications? You found what you�ve been looking for

List of general drug categories: A to Z

A drug category is a way of organizing medications into groups based on shared characteristics. These characteristics can include their chemical structure, how they work in the body, what they’re…

Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Creon 25 (Pancreatic enzyme). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Creon 25 (Pancreatic enzyme).