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Apriso is a prescription medication used to treat ulcerative colitis in adults. It is indicated for the maintenance of remission of ulcerative colitis in patients 18 years of age and older. Apriso contains the active ingredient mesalamine. Apriso belongs to a class of drugs called 5-Aminosalicylic Acid Derivatives. It works by decreasing swelling in the colon.
Mesalamine helps to reduce the symptoms of ulcerative colitis, which can include diarrhea, rectal bleeding, and abdominal pain. Apriso capsules are designed with intellicor technology, which enables the medication to be released slowly in the body over time.
Uses and Dosage
Mesalamine is available in the form of extended-release capsules which release the medication slowly throughout the digestive system. Apriso capsules are designed to be taken by mouth, with or without food, 2 to 4 times a day by adults and twice a day by children, preferably in the morning and afternoon. Swallow the capsules whole; do not split, chew, or crush them.
To ensure that you are taking mesalamine safely and effectively, carefully follow the directions on your prescription label. If there are any parts of the instructions that you do not understand, ask your doctor or pharmacist to explain them to you. Take mesalamine exactly as prescribed by your doctor, without taking more or less of it, or taking it more frequently than directed. Even if you feel better at the beginning of your treatment, continue taking mesalamine until you have finished the entire prescription. Do not stop taking mesalamine without consulting your doctor.
The dosage of mesalamine varies depending on the specific condition being treated, the patient's age, weight, and medical history. Consult a doctor to determine the appropriate dosage for each individual case. However, some general dosing information based on available sources are listed below:
- For adults with ulcerative colitis: 1600 milligrams (mg) per day, taken in 2 to 4 divided doses.
- For children with ulcerative colitis: A doctor must determine use and dose.
- For induction of remission in adult patients with mildly to moderately active ulcerative colitis: 2.4 g to 4.8 g per day, taken in 2 to 4 divided doses
- For maintenance of remission of ulcerative colitis: Dosage ranges from 1.5 to 4.8 g per day and should be determined by a doctor based on weight.
- For mesalamine rectal suppositories in adults: 1000 mg administered rectally once daily at bedtime for 3 to 6 weeks.
Common Side Effects of Apriso (Mesalamine):
- Back pain
- Decreased appetite
- Dry mouth
- Hair loss
- Muscle or joint pain, aching, tightness, or stiffness
Serious Side Effects of Apriso (Mesalamine):
- Black or tarry stools
- Bloody vomit
- Chest pain
- Difficult or painful urination, or pink or red colored urine, or blood in urine
- Difficulty breathing or swallowing
- Extreme tiredness
- Fever or flu-like symptoms
- Mouth sores or blisters
- New or worsening cough
- Pain in the right upper part of the stomach
- Pale stools
- Rash, hives, itching, peeling, or blistering skin
- Shortness of breath
- Side or back pain
- Swelling of any part of the body
- Swelling of the eyes, face, lips, tongue, mouth, or throat
- Swollen glands
- Vomiting material that looks like coffee grounds
- Yellowing of the skin or eyes
Form and strength
Apriso (Mesalamine) is available in the following forms and strength:
Apriso: ER Capsule
Mesalamine: ER Capsule
- Apriso can cause renal impairment, including minimal change nephropathy, acute and chronic interstitial nephritis, and renal failure. Patients with pre-existing renal impairment or a history of renal disease may be at increased risk and should be monitored closely.
- Some patients may experience an acute intolerance syndrome while taking medications containing mesalamine, including Apriso. Symptoms of this syndrome can include cramping, acute abdominal pain, bloody diarrhea, and fever. If you experience these symptoms, you should stop taking Apriso and contact your healthcare provider immediately.
- Use caution when taking Apriso if you have pre-existing liver disease.
- Elderly patients may be more likely to experience blood disorders while taking Apriso. You should be monitored regularly for any changes in your blood count.
Frequently Asked Questions (FAQ)
How is Apriso taken?
Apriso is taken orally in the form of capsules. It is typically taken once a day, with or without food.
Can Apriso be taken during pregnancy or while breastfeeding?
There is limited information about the safety of Apriso during pregnancy or while breastfeeding. If you are pregnant or breastfeeding, you should talk to your healthcare provider before taking Apriso.
What should I do if I miss a dose of Apriso?
If you forget to take a dose of Apriso, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Can Apriso be taken with other medications?
You should always talk to your healthcare provider before taking Apriso with other medications, as some drug interactions can increase the risk of side effects or affect how well the medication works.
How long does it take for Apriso to work?
Apriso may take several weeks to start working, and it is important to continue taking the medication as prescribed even if you do not see immediate improvement in your symptoms.
It's important to purchase Apriso from verified Canadian pharmacy.