Salazopyrin EC (Sulfasalazine)

Indications

Salazopyrin EC (generically known as Sulfasalazine) is a prescription medication medication sulfasalazine, which is commonly used to treat inflammatory bowel disease and rheumatoid arthritis. Sulfasalazine helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding, but does not cure these conditions.

Sulfasalazine works by preventing the production of certain chemicals in the body that cause inflammation, and by helping to reduce irritation and swelling in the large intestines. It is used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease, as well as rheumatoid arthritis and psoriatic arthritis.

Use and Dosage

Salazopyrin EC, also referred to as sulfasalazine, is a tablet that should be taken orally after meals with a full glass of water (8 ounces or 240 milliliters), or as prescribed by your doctor. To avoid stomach irritation, your doctor may gradually increase your dose when beginning treatment. The dosage is determined by your medical condition and your reaction to the medication. In children, the dosage is also based on their weight.

If you are using the delayed-release tablets, you must swallow them whole. Chewing, crushing, or breaking the tablets can increase the chance of stomach irritation. During treatment with the tablet, make sure to drink plenty of fluids, unless instructed otherwise by your doctor, to prevent the formation of kidney stones.

To obtain the maximum advantage from the tablet, take it routinely at the same time each day, and set a reminder if necessary. You should notify your doctor if your condition does not improve or worsens. It may take 1-3 months to notice an improvement in symptoms for the treatment of rheumatoid arthritis.

Side Effects

Common Side Effects of Salazopyrin EC (Sulfasalazine):

• Aching of joints
• Anorexia
• Fever
• Gastric distress
• Headache (continuing)
• Increased sensitivity of the skin to sunlight
• Nausea
• Reversible oligospermia
• Skin rash or itching
• Vomiting

Serious Side Effects of Salazopyrin EC (Sulfasalazine):

• Back, leg, or stomach pains
• Bleeding gums
• Bluish color of the fingernails, lips, skin, palms, or nail beds
• Chills
• Cyanosis
• Dark urine
• Difficulty breathing
• Fever
• General body swelling
• Headache
• Heinz body anemia
• Hemolytic anemia
• Loss of appetite
• Nausea
• Nosebleeds
• Pale skin
• Pruritus
• Skin rash
• Sore throat
• Trouble breathing
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Urticaria
• Yellowing of the eyes or skin

Forms and Strength

Salazopyrin EC (Sulfasalazine) is available in the following forms and strength:

Salazopyrin EC: EC Tablet

• 500 mg

Sulfasalazine: Delayed Release Tablet

• 500 mg

Cautions

• Allergic reactions: Salazopyrin EC may cause allergic reactions in some people, especially those who are allergic to sulfa drugs. Signs of an allergic reaction may include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.
• Blood disorders: Salazopyrin EC may cause blood disorders in some people, such as low white blood cell count, low platelet count, or megaloblastic anemia.
• Liver and kidney problems: Salazopyrin EC may cause liver or kidney problems in some people, so regular blood tests may be necessary to monitor liver and kidney function.
• Pregnancy and breastfeeding: Salazopyrin EC may be harmful to a developing fetus and may pass into breast milk, let a healthcare provider know if you are pregnant, planning to become pregnant, or breastfeeding.
• Interactions with other medications: Salazopyrin EC may interact with other medications, including blood thinners, folic acid supplements, and certain antibiotics, let a healthcare provider know about all medications you are taking.
• Gastrointestinal side effects: Salazopyrin EC may cause gastrointestinal side effects such as nausea, vomiting, abdominal pain, and diarrhea in some people. These side effects may be minimized by taking the medication with food or a full glass of water.
• Skin reactions: Salazopyrin EC may cause skin reactions such as rash, itching, or blistering in some people. If you experience any skin reactions, you should stop taking the medication and contact your healthcare provider.
• Fluid retention: Salazopyrin EC may cause fluid retention in some people, which can lead to swelling in the legs, feet, or ankles.
• Sun sensitivity: Salazopyrin EC may increase sensitivity to sunlight, so use sunscreen and wear protective clothing when spending time outdoors.
• Eye problems: Salazopyrin EC may cause eye problems such as blurred vision or eye pain in some people, report any vision changes to your healthcare provider.
• Impaired fertility: Salazopyrin EC may impair male fertility in some people, but the effects are usually reversible when the medication is stopped.

Frequently Asked Questions (FAQ)

How often should blood tests be done while taking Salazopyrin EC?

Blood tests may be necessary to monitor liver and kidney function while taking Salazopyrin EC.

How long does it take for Salazopyrin EC (sulfasalazine) to work?

The time it takes for Salazopyrin EC to work can vary depending on the individual and the condition being treated. It may take several weeks to see an improvement in symptoms.

Can Salazopyrin EC (sulfasalazine) be used while breastfeeding?

Salazopyrin EC may pass into breast milk and harm a nursing baby. You should talk to your doctor if you are breastfeeding before taking Salazopy.

Resources

• https://www.healthline.com/health/drugs/sulfasalazine-oral-tablet
• https://www.webmd.com/drugs/2/drug-22470/sulfazine-ec-oral/details
• https://www.uptodate.com/contents/image?imageKey=GAST%2F86818
• https://www.royaldevon.nhs.uk/media/hjwh2twh/sulphasalazine.pdf
• https://www.drugs.com/sulfasalazine.html#side-effects