Prescription Required
Formulation: Tablet
(Brand Option)
Select the prescribed dosage
Select the quantity to see the price.
Prescription Required
Formulation: Tablet
(Generic Alternative)
Select the prescribed dosage
Select the quantity to see the price.
* This price includes a dispensing fee, medical review fee, and packing fee.
Shipped and delivered directly to your doorstep
Comtan (active ingredient: entacapone) is a prescription medication used together with levodopa/carbidopa to help manage Parkinson’s disease symptoms in people who experience end-of-dose wearing-off.
Comtan does not replace levodopa/carbidopa. Instead, it helps levodopa stay active in the body for a longer period.
Parkinson’s disease is a long-term neurological condition that affects movement.
It develops when the brain does not have enough dopamine, a chemical that helps control smooth and coordinated movement.
Common symptoms may include:
Levodopa is one of the main medicines used to replace dopamine activity in the brain and improve these symptoms.
End-of-Dose Wearing-Off
Comtan is used in people with Parkinson’s disease who are already taking levodopa/carbidopa but notice that its effects do not last until the next dose.
This is known as wearing-off.
During a wearing-off period, symptoms that had improved after taking levodopa may begin to return.
A person may notice:
Comtan helps extend the effect of each levodopa/carbidopa dose so these “off” periods may occur less often or last for a shorter time.
Comtan belongs to a class of medicines called catechol-O-methyltransferase inhibitors, or COMT inhibitors.
The Body Normally Breaks Down Levodopa
After levodopa is taken, part of it is broken down in the body before it can reach the brain.
One of the enzymes involved in this process is called catechol-O-methyltransferase, or COMT.
When more levodopa is broken down, less is available to reach the brain.
Comtan Blocks the COMT Enzyme
Entacapone blocks the COMT enzyme outside the brain.
This slows the breakdown of levodopa and allows more levodopa to remain in the bloodstream for a longer period.
More Levodopa Reaches the Brain
Because levodopa is broken down more slowly, a greater amount remains available to cross into the brain.
Once inside the brain, levodopa is converted into dopamine.
This helps replace some of the dopamine that is lacking in Parkinson’s disease.
Helps Levodopa Last Longer
The main benefit of Comtan is that it can extend the effect of levodopa/carbidopa.
This may help reduce the return of Parkinson’s symptoms before the next scheduled levodopa dose.
People taking levodopa may experience periods when the medicine works well and periods when its effect becomes weaker.
An “on” period is when Parkinson’s symptoms are better controlled and movement may be easier.
An “off” period occurs when the effect of levodopa wears off and symptoms such as stiffness, tremor, or slow movement begin to return.
Comtan may increase “on” time and reduce some “off” time by helping each levodopa dose last longer.
Comtan does not have a useful effect on Parkinson’s symptoms when used by itself.
It works specifically by changing how the body processes levodopa.
Carbidopa is included with levodopa to reduce the breakdown of levodopa before it reaches the brain, while Comtan blocks another breakdown pathway involving the COMT enzyme.
Together, these medicines can help make levodopa treatment more effective.
Because Comtan increases the amount and duration of levodopa in the body, it may also increase some levodopa-related side effects.
These may include:
If these effects become troublesome, your healthcare provider may adjust your levodopa/carbidopa dose.
Some people may notice that their levodopa dose lasts longer after Comtan is added to treatment.
The amount of improvement varies from person to person.
Your healthcare provider may monitor how much “off” time you experience, how well you move during “on” periods, and whether you develop increased involuntary movements.
Comtan helps improve the effectiveness of levodopa treatment, but it does not cure Parkinson’s disease or stop the underlying condition from progressing.
Parkinson’s disease usually requires long-term treatment and regular follow-up.
Take Comtan exactly as prescribed and always take it together with your levodopa/carbidopa regimen.
Do not stop Comtan or suddenly change your Parkinson’s medications without speaking with your healthcare provider. Changes in dopaminergic treatment may need to be made gradually to reduce the risk of serious withdrawal-related symptoms.
Comtan comes as a tablet that is taken by mouth. It is used together with levodopa/carbidopa and is usually taken at the same time as each prescribed levodopa/carbidopa dose.
The usual Comtan dose is 200 mg with each levodopa/carbidopa dose, up to a maximum of 8 Comtan tablets, or 1,600 mg, in 24 hours.
Comtan should not be taken by itself for Parkinson’s disease.
It works by helping levodopa stay active in the body for a longer period. Because of this, each Comtan dose is usually taken together with a scheduled dose of levodopa/carbidopa.
The typical dose is one 200 mg tablet taken with each dose of levodopa/carbidopa.
Depending on your Parkinson’s treatment schedule, you may take Comtan several times during the day.
Your healthcare provider will decide how often you should take it based on your levodopa/carbidopa schedule and how well your symptoms are controlled.
Do not take more than 1,600 mg of Comtan in 24 hours.
This equals a maximum of eight 200 mg tablets per day.
Taking more than the prescribed amount may increase the risk of side effects.
Comtan can be taken with or without food.
If it causes nausea or stomach discomfort, taking it with food may make it easier to tolerate.
Rather than taking Comtan at one fixed time every day, take it according to your levodopa/carbidopa dosing schedule.
For example, if your healthcare provider has prescribed several levodopa/carbidopa doses throughout the day, Comtan may be taken with each of those doses.
Following the correct schedule helps Comtan extend the effect of levodopa and reduce end-of-dose wearing-off.
Use Comtan consistently as prescribed.
Regular treatment may help reduce the periods when levodopa wears off and Parkinson’s symptoms such as stiffness, tremor, or slow movement begin to return.
Do not take extra tablets because you are experiencing more symptoms unless your healthcare provider tells you to do so.
Comtan increases the amount and duration of levodopa available in the body.
After Comtan is started, some people may experience stronger levodopa effects, including:
If these effects occur, your healthcare provider may reduce or adjust your levodopa/carbidopa dose rather than changing Comtan on your own.
Because Comtan is normally taken with levodopa/carbidopa, follow the dosing instructions provided by your healthcare provider if you miss a dose.
Do not take two Comtan tablets at the same time or take extra medication to make up for a missed dose.
If you are unsure how to handle a missed dose, contact your healthcare provider or pharmacist.
Do not suddenly stop taking Comtan without medical advice.
Stopping Comtan may shorten the effect of levodopa and cause Parkinson’s symptoms to become worse.
Sudden changes in Parkinson’s medicines can also rarely lead to a serious reaction with symptoms such as high fever, severe muscle stiffness, confusion, and changes in heart rate or blood pressure.
Your healthcare provider may need to adjust your levodopa/carbidopa treatment if Comtan is stopped.
Tell your healthcare provider if you have liver disease or reduced liver function.
Entacapone is processed by the liver, and liver problems can increase the amount of medication in the body. Your healthcare provider may need to consider this when deciding whether Comtan is appropriate for you.
Pay attention to changes in how long each levodopa dose works.
Tell your healthcare provider if you notice:
These changes can help your healthcare provider decide whether your Parkinson’s treatment needs adjustment.
Take one 200 mg Comtan tablet with each prescribed levodopa/carbidopa dose, unless your healthcare provider gives you different instructions.
Do not exceed eight tablets or 1,600 mg in 24 hours, and do not increase, decrease, or stop your Parkinson’s medicines without first speaking with your healthcare provider.
Comtan (Entacapone) is available in the following forms and strength:
Tell your healthcare provider if you have liver disease or reduced liver function before taking Comtan.
Entacapone is processed by the liver, so liver problems can affect how the medication is handled by the body. Your healthcare provider may need to monitor you more closely during treatment.
Comtan may interact with certain medications, including some antidepressants, antipsychotics, and monoamine oxidase (MAO) inhibitors.
These interactions may increase the risk of side effects or change how the medicines work.
Tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, and supplements you take before starting Comtan.
Comtan may cause hallucinations, confusion, mood changes, or unusual behavior in some people.
Tell your healthcare provider if you notice new or worsening hallucinations, agitation, confusion, unusual thoughts, or major changes in behavior.
Entacapone may cause orthostatic hypotension, which is a sudden drop in blood pressure when you stand up from sitting or lying down.
This may cause dizziness, lightheadedness, or fainting.
Stand up slowly and use extra caution if you already have low blood pressure or take medicines that lower blood pressure.
Comtan can increase the effects of levodopa and may cause or worsen dyskinesia.
Dyskinesia refers to uncontrolled or involuntary movements of the face, arms, legs, or other parts of the body.
If these movements become troublesome, your healthcare provider may need to adjust your levodopa/carbidopa dose.
Your levodopa/carbidopa dose may need to be changed after Comtan is added to your treatment.
Because Comtan makes levodopa last longer, side effects related to levodopa may become more noticeable.
Do not change either medication on your own. Your healthcare provider will adjust your treatment if needed.
People with Parkinson’s disease may have a higher risk of melanoma.
Tell your healthcare provider if you have a history of melanoma or another skin cancer. Check your skin regularly and report any new or changing moles or unusual skin lesions.
Tell your healthcare provider if you have heart disease, an irregular heartbeat, or other cardiovascular problems.
Your healthcare provider may monitor you more closely if you have a history of cardiovascular disease.
Alcohol may increase dizziness, drowsiness, or low blood pressure while taking Comtan.
Avoid or limit alcohol unless your healthcare provider says it is safe for you.
Medicines that lower blood pressure may increase the risk of dizziness or fainting when taken with Comtan.
Tell your healthcare provider if you take blood pressure medicines or other drugs that can cause low blood pressure.
Take Comtan exactly as prescribed and report new or worsening side effects promptly.
Contact your healthcare provider if you develop severe dizziness, fainting, hallucinations, unusual behavior, or troublesome involuntary movements.
Talk to your healthcare provider before taking Comtan if you are pregnant, planning to become pregnant, or breastfeeding. There is limited information about the use of entacapone during pregnancy. It should be used only when your healthcare provider determines that the potential benefits outweigh the possible risks. It is also not known whether entacapone passes into human breast milk, so breastfeeding should be discussed with your healthcare provider.
Comtan begins affecting levodopa from the first dose. It works by slowing the breakdown of levodopa, helping levodopa levels stay higher for longer. The exact amount of symptom relief and how long it lasts can vary depending on your levodopa/carbidopa dose and your individual response. The prescribing information does not establish a standard “1 to 2 hours to start” and “4 to 6 hours of effect” for every patient.
No. Comtan is intended to be used together with levodopa/carbidopa in people with Parkinson’s disease who experience end-of-dose wearing-off. Comtan does not provide a useful Parkinson’s treatment effect when used by itself because its main purpose is to extend the effect of levodopa.
Store Comtan at room temperature, ideally around 25°C (77°F). Short-term temperatures between 15°C and 30°C (59°F to 86°F) are acceptable. Keep the medication in its original container and protect it from inappropriate heat or moisture.
Because Comtan is normally taken with each scheduled levodopa/carbidopa dose, follow the dosing instructions provided by your healthcare provider if you miss a dose. Do not take two doses at the same time or take extra Comtan to make up for a missed dose. Continue with your prescribed levodopa/carbidopa and Comtan schedule unless your healthcare provider gives you different instructions.
| Generic name: | Entacapone |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 200mg |
| Quantities Available: | 90, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Comtan (entacapone) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time. This practice is common for prescription medications to ensure adequate management of chronic conditions without the need for frequent refills.
Here’s what you need to know:
Dosage and Quantity: Comtan is commonly prescribed in dosages of 200 mg, taken up to 8 times per day. For a 90-day supply, this means you would order up to 720 tablets (90 days x 8 tablets per day).
Yes, we sell entacapone at competitive prices. You will need a valid prescription from your healthcare provider to purchase this medication. We require this to ensure the safe and proper dispensing of entacapone. You can conveniently provide your prescription by mailing, faxing, or uploading it through your online account on our website.
Yes, we ship Comtan (entacapone) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Comtan (Entacapone). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Comtan (Entacapone).
REVIEWS