Depakote CR (Divalproex) Shopper Approved

Prescription Prescription Required FormationFormulation: Controlled Release Tablet

Depakote CR

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Prescription Prescription Required FormationFormulation: Controlled Release Tablet


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Depakote is an oral medication prescribed to treat several types of seizure disorder by affecting certain body chemicals that cause seizures. Depakote can also treat other illnesses such as the manic phase of bipolar disorder (Manic depressive illness). Migraine headaches can also be prevented by using Depakote.

Depakote contains an active ingredient called Divalproex. Divalproex belongs to anticonvulsant and mood stabilizer drugs. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Use and Dosage

Divalproex comes as a controlled release tablet and should be taken by mouth once daily or as directed by a doctor. To avoid stomach upset, it can be taken with food and should be swallowed whole. The tablet should not be crushed or chewed as it can release all the drug at once, increasing the risk of side effects. While taking Depakote, be sure to drink lots of water to keep your fluids up. Have your liver tested regularly and schedule regular visits with your doctor.

The dosage of the medication is based on several factors including age, weight, medical condition, and response to treatment, and the medication should be used regularly to ensure maximum benefit. Use the medication at the same time each day to maintain a consistent level of medication in your blood.

If Depakote CR is being used to treat seizures, do not to stop taking the medication suddenly without consulting a doctor, as doing so can worsen the condition. The dose may need to be gradually decreased over time. It does not relieve acute migraine headaches and other medications should be taken as directed by a doctor for acute attacks.

Inform a doctor or pharmacist about all medications being taken, including prescription drugs, non-prescription drugs, and herbal products, as they can interact with Depakote CR and affect its effectiveness or increase the risk of side effects.

Side Effects

Common Side Effects of Depakote CR (Divalproex):

  • Blurred/double vision or vision changes
  • Changes in menstrual periods
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Enlarged breasts
  • Hair loss
  • Loss of appetite
  • Low fever
  • Nausea
  • Ringing in the ears
  • Shakiness (tremor)
  • Stomach pain
  • Unsteadiness
  • Unusual or unpleasant taste in your mouth or
  • Upset stomach
  • Vomiting
  • Weakness
  • Weight changes

Serious Side Effects of Depakote CR (Divalproex):

  • Anxiety
  • Blood in your urine
  • Changes in your menstrual periods
  • Clay colored stool
  • Confusion or fainting
  • Dark urine
  • Depression
  • Easy bruising or bleeding
  • Enlarged breasts
  • Fever
  • Hair loss
  • Headache with a severe blistering, peeling, and red skin
  • Hostile
  • Hyperactive
  • Mild drowsiness or weakness
  • Mood changes
  • Other emotional changes
  • Restless
  • Sore throat
  • Suicidal
  • Tremor (shaking)
  • Unexplained weakness
  • Unusual or unpleasant taste in your mouth
  • Upset stomach
  • Vision changes
  • Yellow eyes then you may have liver damage
  • Yellow skin

Forms and Strength

Depakote CR (Divalproex) is available in the following forms and strength:

Divalproex: Controlled Release Tablet

  • 500mg


  • Use in Women of Childbearing Potential: Divalproex may cause birth defects and fetal harm when administered to a pregnant woman. Women of childbearing potential should use effective contraception while taking divalproex.
  • Liver Damage: Avoid taking Depakote if you have liver disease or a urea cycle disorder.
  • Bleeding Risk: Divalproex may interfere with blood clotting and increase the risk of bleeding. Patients with a history of bleeding disorders or those taking medications that increase bleeding risk should be closely monitored.
  • Pancreatitis: Divalproex may cause inflammation of the pancreas. Patients should be advised to report symptoms such as abdominal pain, nausea, and vomiting.
  • Allergic Reactions: Divalproex may cause allergic reactions, including skin rash, hives, and fever. Patients should be advised to report any signs of allergy promptly.
  • Medication Interactions: Divalproex may interact with other medications, including alcohol, increasing the risk of side effects. Patients should inform their healthcare provider of all medications they are taking.
  • Cognitive and Motor Impairment: Divalproex may impair cognitive and motor function, which can affect the ability to drive or operate machinery.
  • Hyperammonemia: Divalproex may cause hyperammonemia, a condition characterized by elevated ammonia levels in the blood. This can lead to symptoms such as confusion, lethargy, and seizures.
  • Kidney Damage: Divalproex may cause kidney damage. Regular monitoring of kidney function tests is recommended.
  • Suicidal Thoughts and Behavior: Divalproex may increase the risk of suicidal thoughts and behavior, particularly in younger patients. Patients should be monitored for signs of suicidal ideation and behavior.
  • Do not drink alcohol while taking Depakote: Depakote may reduce your reaction speed and impair your thinking.

Frequently Asked Questions (FAQ)

Is it safe to stop taking Depakote CR abruptly?

No, it is not safe to stop taking Depakote CR abruptly. Doing so can cause seizures or other serious withdrawal symptoms.

Can Depakote CR be taken with other medications?

Depakote CR can interact with other medications, tell a doctor about all medications, vitamins, and supplements that are being taken. Some medications may cause interactions that can make side effects worse or reduce the effectiveness of the medication.

How long does it take for Depakote CR to start working?

The time it takes for Depakote CR to start working can vary from person to person and depending on the condition being treated. It may take several weeks or longer to see the full benefits of the medication.

How is Depakote CR different from Depakote delayed release?

Depakote CR is an extended-release form of the medication Divalproex, while Depakote delayed-release is a regular-release form of the same medication. The extended-release formula allows for a slower and more gradual release of the medication into the bloodstream.


Additional information

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Controlled Release Tablet



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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Depakote CR (Divalproex). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Depakote CR (Divalproex).