Indications
Depakene oral solution is a prescription medication used to treat seizure disorders, manic phase of bipolar disorder, and to prevent migraine headaches. It contains valproic acid as its active ingredient.
Depakene Oral Solution works by restoring the balance of certain natural substances, called neurotransmitters, in the brain. It is an anticonvulsant that is used to prevent and control seizures in people with epilepsy.
Depakene oral solution should be taken exactly as prescribed by a healthcare provider. The dosage will depend on the individual's condition and response to treatment.
Use and Dosage
Take Depakene Oral Solution by mouth as directed by your doctor. You may take it with food if stomach upset occurs. Use a specially marked device to measure the correct amount of medication. Valproate sodium syrup should not be mixed with carbonated drinks because it may irritate the mouth and throat.
The dosage is based on your age, weight, medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use Depakene Oral Solution regularly to get the most benefit from it. Remember to use it at the same time each day to keep the amount of medication in your blood constant. If Depakene Oral Solution is used for seizures, do not stop taking it without consulting your doctor.
Your condition may become worse if the drug is suddenly stopped. Your dose may need to be gradually decreased. Depakene Oral Solution does not relieve acute migraine headaches. Take other medications as directed by your doctor for acute attacks.
Side Effects
Common Side Effects of Depakene Oral Solution (Valproic Acid):
- Diarrhea
- Dizziness
- Fatigue or tiredness
- Headache
- Indigestion
- Nausea
- Sedation
- Vomiting
- Weakness
- Weight gain due to increased appetite
Serious Side Effects of Depakene Oral Solution (Valproic Acid):
- Bleeding gums
- Blood in urine
- Brown or discolored urine
- Bruising
- Change in the amount or color of urine
- Changes in sleep
- Changes in weight
- Confusion
- Coughing blood
- Dark urine
- Decreased interest in activities
- Decreased level of consciousness
- Diarrhea
- Difficulty reading, speaking, or understanding
- Hair loss or increased hair on face, chest, and back
- Hallucinations (seeing or hearing things that aren't there)
- Increase in seizures
- Increased urination at night
- Increasing tiredness
- Loss of appetite
- Low energy
- Memory loss
- Muscle pain
- Nausea
- Nausea or vomiting (continuing)
- Pale stools
- Poor concentration
- Shivering
- Slow, shallow breathing
- Slurred speech
- Swelling in the feet or legs
- Tenderness or weakness
- Thoughts of suicide
- Tremor
- Unusual nosebleeds
- Unwell
- Urinary incontinence
- Vomiting
- Weakness with behavior changes (extreme irritability, combativeness)
- Weight loss
- Yellowing of the skin or whites of the eyes
Forms and Strength
Depakene Oral Solution (Valproic Acid) is available in the following forms and strength:
Depakene Oral Solution: Syrup
- 250mg/5mL
Valproic Acid: Syrup
- 250mg/5mL
Cautions
- Risk of liver failure: Depakene Oral Solution can cause liver damage or failure, especially in children under the age of two and people with certain genetic conditions. Liver function should be regularly monitored while using the solution.
- Pancreatitis: Valproic acid can cause inflammation of the pancreas, leading to abdominal pain, nausea, and vomiting. Seek medical attention if these symptoms occur.
- Risk of birth defects: Valproic acid can cause birth defects if taken during pregnancy. Women of childbearing age should use effective contraception while taking Valproic acid and discuss the risks and benefits with their doctor.
- Bleeding disorders: Depakene Oral Solution can interfere with blood clotting and increase the risk of bleeding. People with bleeding disorders or those taking blood-thinning medication should use caution while taking the solution.
- Cognitive and behavioral changes: Valproic acid can cause changes in mood, behavior, and thinking. Patients should be closely monitored for any signs of confusion, depression, or agitation.
- Allergic reactions: Depakene Oral Solution can cause allergic reactions in some people, including fever, rash, and swelling of the face, tongue, or throat. Seek medical attention immediately if these symptoms occur.
- Fluid and electrolyte imbalances: Valproic acid can cause changes in the levels of fluids and electrolytes in the body, leading to dehydration and kidney damage. Patients should drink plenty of fluids while taking the solution.
- Respiratory problems: Depakene Oral Solution can cause respiratory depression, especially in people with a history of respiratory problems. Patients should be closely monitored for any signs of difficulty breathing.
- Interactions with other medications: Valproic acid may interact with certain medications, including other anti-seizure drugs, blood-thinning medications, and antidepressants. Patients should inform their doctor of all medications they are taking.
- Increased risk of suicidal thoughts or behavior: Depakene Oral Solution can increase the risk of suicidal thoughts or behavior, particularly in children and young adults. Patients should be closely monitored for any signs of suicidal thoughts or behavior while taking the solution.
Frequently Asked Questions (FAQ)
How long does it take for Depakene Oral Solution to start working?
Depakene Oral Solution can take several weeks to reach its full effectiveness. Your doctor will monitor your symptoms and adjust your dosage accordingly.
Can children take Depakene Oral Solution?
Depakene Oral Solution is approved for use in children with certain types of seizures. However, it can cause liver damage or failure in children under the age of two.
Is it safe to drink alcohol while taking Depakene Oral Solution?
Drinking alcohol can increase the risk of certain side effects of Depakene Oral Solution, such as drowsiness and dizziness. Patients should consult their doctor before consuming alcohol while taking the solution.
Can Depakene Oral Solution be taken with food?
Yes, Depakene Oral Solution should be taken with food to avoid stomach upset.
Resources
- https://dailymed.nlm.nih.gov/dailymed/medguide.cfm?setid=6b4331f5-4475-417a-6a9d-09c2f8334235
- https://www.webmd.com/drugs/2/drug-9702-9019/depakene-oral/valproate-sodium-syrup-oral/details
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018081s056lbl.pdf
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018081s046_18082s031lbl.pdf
- https://www.medbroadcast.com/drug/getdrug/depakene
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