Combipatch (Estradiol 17b/Norethindrone Acetate) Shopper Approved

Prescription Prescription Required FormationFormulation:


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Prescription Prescription Required FormationFormulation:

Estradiol 17b/Norethindrone Acetate

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CombiPatch is a prescription medication administered as a transdermal patch to alleviate symptoms associated with menopause in women, such as hot flashes, vaginal dryness, and mood changes. It is containing a combination of two female hormones, estradiol and norethindrone acetate. By providing the body with the hormones it needs, CombiPatch can alleviate many of the symptoms of menopause.

The estradiol component replaces the natural decline in estrogen levels that occurs during menopause, while the norethindrone component helps to prevent thickening of the uterine lining that can lead to endometrial hyperplasia. CombiPatch works by affecting the levels of these hormones in the body and restoring hormonal balance.

Uses and Dosage

To use CombiPatch, follow these specific instructions for application:

  1. Peel off the backing from the patch.
  2. Apply the patch onto a clean and dry area of the lower stomach, pressing it firmly in place for about 10 seconds to ensure it sticks properly.
  3. Do not apply the patch on the breast or on oily, broken, or irritated skin.
  4. Avoid applying the patch to areas of the skin where it might be easily rubbed off, such as the waistline.
  5. When wearing the patch, do not expose it to the sun for extended periods of time.
  6. Use this medication as directed by your healthcare provider.
  7. The patch is usually replaced twice a week every 3 to 4 days.
  8. Follow the prescribed dosing schedule carefully, as directed by your healthcare provider.

After applying the patch, you should replace it every three to four days or twice a week, as directed by your healthcare provider. To prevent skin irritation, you should avoid applying the patch to the same area of skin each time. Instead, rotate the sites of application with an interval of at least one week allowed. This will also help ensure that the medication is absorbed properly.

If you are using CombiPatch, apply 1 patch onto your lower stomach below your waistline, and replace it twice a week (every 3 to 4 days).

Side Effect

Common Side Effects of Combipatch (Estradiol 17b/Norethindrone Acetate):

  • Nausea
  • Headache
  • Weakness
  • Vomiting
  • Redness or irritation on the application site
  • Abdominal pain
  • Breast tenderness
  • Back pain
  • Weight changes
  • Dark patches on the face

Serious Side Effects of Combipatch (Estradiol 17b/Norethindrone Acetate):

  • Mental or mood changes
  • Breast lumps
  • Unusual vaginal bleeding
  • Increased vaginal irritation
  • Unusual vaginal odor or discharge
  • Swelling of the extremities
  • Increased thirst or urination
  • Blood clots

Form and Strength

Combipatch (Estradiol 17b/Norethindrone Acetate) is available in the following forms and strength:

Combipatch: Patch

  • 0.05/0.14 mg
  • 0.05/0.25 mg


  • CombiPatch may interact with other medications, including some herbal supplements, and is not used with certain medical conditions.
  • If a patient experiences an allergic reaction to CombiPatch, such as rash, itching, or difficulty breathing, they should seek medical attention immediately and discontinue use of the medication.
  • CombiPatch may cause side effects, which can include headache, breast pain, vaginal bleeding, nausea, and mood changes. Patients should report any new or worsening symptoms to their healthcare provider immediately.
  • CombiPatch is not used for children and is not recommended for use in pregnant or breastfeeding women.
  • CombiPatch should not be used for patients with certain medical conditions, such as liver or kidney disease, gallbladder disease, high blood pressure, diabetes, or a history of migraines.
  • CombiPatch may not be used for patients with a history of certain medical conditions, such as breast cancer, uterine cancer, ovarian cancer, or blood clots.
  • Higher doses of CombiPatch may increase the risk of side effects, such as breast tenderness, fluid retention, or weight changes.
  • Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.

Frequently Asked Questions (FAQ)

How long can I use CombiPatch?

The duration of therapy with CombiPatch should be determined by a healthcare professional based on individual needs and risks. Patients should follow the directions of their healthcare provider regarding duration of treatment.

What should I do if I miss a dose of CombiPatch?

If a patient misses a dose of CombiPatch, the patch should be applied as soon as possible. If it is close to the time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed.

How should I store CombiPatch?

CombiPatch should be stored at room temperature, away from heat and direct sunlight. The patch should be kept in its protective pouch until it is ready to be used.

Can I shower, swim, or exercise while wearing a CombiPatch?

CombiPatch helps to stay securely in place during normal daily activities, including showering, swimming, and exercise. Patients should follow the instructions of their healthcare provider regarding any limitations or precautions while wearing the patch.

How long should you use CombiPatch (estradiol / norethindrone)?

Your provider might check in on you 3 to 6 months after you start using CombiPatch (estradiol / norethindrone) to see if your symptoms are improving and if you can stop using the patch.


Additional information

Generic name:

Estradiol 17b/Norethindrone Acetate




0.05/0.14mg, 0.05/0.25mg

Quantities Available:

8, 24


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Combipatch (Estradiol 17b/Norethindrone Acetate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Combipatch (Estradiol 17b/Norethindrone Acetate).