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Apresoline

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Prescription Prescription Required FormationFormulation: Tablet

Hydralazine

(Generic Alternative)

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Apresoline contains the active ingredient hydralazine. It is a prescription medication used to lower high blood pressure and, in certain treatment plans, help manage heart failure.

Hydralazine relaxes and widens the arteries. This allows blood to flow more easily and reduces the resistance against which the heart must pump.

Understanding High Blood Pressure

High blood pressure, also called hypertension, occurs when blood pushes against the walls of the arteries with too much force.

Over time, uncontrolled blood pressure can damage the heart, blood vessels, kidneys, eyes, and brain. It may increase the risk of:

  • Heart attack
  • Stroke
  • Heart failure
  • Kidney disease
  • Vision loss

High blood pressure often does not cause noticeable symptoms. A person may feel well even when their blood pressure is dangerously high.

Treatment of High Blood Pressure

Apresoline may be used alone or together with other blood pressure medications. It is often considered when other treatments do not provide enough control or cannot be used.

By widening the arteries, Apresoline lowers resistance to blood flow and helps reduce blood pressure.

Lowering blood pressure may help:

  • Reduce strain on the heart
  • Protect the blood vessels
  • Lower the risk of stroke
  • Reduce the risk of heart-related complications
  • Protect kidney function over time

Apresoline controls high blood pressure but does not cure it. Regular treatment may be needed even when you feel well.

Understanding Heart Failure

Heart failure occurs when the heart cannot pump enough blood to meet the body’s needs.

It does not mean that the heart has completely stopped working. Instead, the heart has become too weak or stiff to pump efficiently.

Possible symptoms include:

  • Shortness of breath
  • Tiredness or weakness
  • Swelling in the feet, ankles, or legs
  • Rapid weight gain caused by fluid retention
  • Difficulty exercising
  • Coughing or breathing problems when lying down
  • A fast or irregular heartbeat

Symptoms may become worse when the body retains too much salt and water.

Role in Heart Failure Treatment

Hydralazine may be used with other medications as part of a heart failure treatment plan.

It is commonly combined with a nitrate medication, such as isosorbide dinitrate. Together, these medicines widen different types of blood vessels and reduce the workload placed on the heart.

The hydralazine and isosorbide dinitrate combination is used as an additional treatment for certain patients with heart failure and may improve symptoms and reduce hospitalization risk.

Other heart failure treatments may include:

  • Diuretics to remove extra fluid
  • Beta-blockers
  • ACE inhibitors or related medications
  • Mineralocorticoid receptor antagonists
  • Other medicines that support heart function

Do not stop or change another heart medication when starting Apresoline unless your healthcare provider tells you to do so.

How Apresoline Works

Apresoline belongs to a class of medications called direct-acting vasodilators.

It acts mainly on the smooth muscles in the walls of the arteries. When these muscles relax, the arteries widen.

This produces several effects:

  • Blood pressure decreases
  • Resistance to blood flow is reduced
  • Blood moves more easily through the arteries
  • The heart can pump against less pressure
  • Blood flow to body tissues may improve

Hydralazine generally reduces diastolic blood pressure more than systolic blood pressure. It may also cause the heart rate and cardiac output to increase as the body responds to the widened blood vessels.

Why Other Medications May Be Needed

When Apresoline widens the arteries, the body may respond by increasing the heart rate and retaining salt and water.

For this reason, a healthcare provider may prescribe it with:

  • A beta-blocker to control a rapid heartbeat
  • A diuretic to reduce fluid retention
  • Other blood pressure medications to improve overall control

Using several medications together may allow blood pressure to be controlled with lower doses of each medicine.

Expected Benefits

When Apresoline is working effectively, it may help:

  • Lower blood pressure readings
  • Reduce strain on the heart
  • Improve blood flow
  • Make some heart failure symptoms easier to manage
  • Reduce breathing difficulty caused by heart strain
  • Improve the ability to perform daily activities

You may not feel a noticeable difference when your blood pressure improves. Blood pressure measurements and medical examinations are used to determine whether treatment is working.

Gradual Dose Adjustment

A healthcare provider may begin treatment with a low dose and gradually increase it.

Increasing the dose slowly can help reduce side effects such as:

  • Headache
  • Dizziness
  • Flushing
  • Nausea
  • A rapid or pounding heartbeat
  • Low blood pressure

Do not increase the dose because your blood pressure remains high after only a few doses. It may take time to determine the most effective treatment schedule.

Regular Monitoring

Your healthcare provider may monitor:

  • Blood pressure
  • Heart rate
  • Heart failure symptoms
  • Swelling and body weight
  • Kidney function
  • Blood-cell counts
  • Signs of medication-related side effects

Blood tests may also be needed during longer treatment because hydralazine can rarely cause an immune reaction similar to lupus.

Role in Long-Term Care

Apresoline can help manage high blood pressure and heart failure, but it does not permanently cure either condition.

Treatment may also include:

  • A heart-healthy diet
  • Limiting sodium
  • Regular physical activity when medically appropriate
  • Maintaining a healthy weight
  • Avoiding smoking
  • Taking other prescribed heart medications
  • Monitoring blood pressure at home

Take Apresoline consistently and attend all scheduled follow-up appointments. Contact your healthcare provider if your blood pressure remains high, your heart failure symptoms worsen, or you develop significant side effects.

Take Apresoline exactly as prescribed by your healthcare provider.

Hydralazine comes as an oral tablet and is usually taken several times each day. Depending on your treatment plan, it may be taken two to four times daily.

Swallow the tablet with water. Take each dose at approximately the same times every day to maintain a steady amount of medication in your body.

Taking Apresoline With Food

Apresoline may be taken with or without food. However, food can affect how the body absorbs hydralazine.

Take every dose consistently in the same way. For example, if you usually take it with food, continue taking it with food each day.

Following a consistent routine helps the medication work more predictably.

Starting With a Low Dose

Apresoline is often started at a low dose and gradually increased.

Increasing the dose slowly allows your healthcare provider to assess how your blood pressure responds. It may also reduce the risk of headache, flushing, dizziness, nausea, or a rapid heartbeat.

Do not increase the dose on your own, even if your blood pressure remains high during the first few days.

Common Starting Schedule

A commonly recommended adult schedule for high blood pressure is:

  • 10 mg four times daily for the first two to four days
  • 25 mg four times daily for the rest of the first week
  • 50 mg four times daily beginning in the second week

This is a general dosing schedule from hydralazine prescribing information. Your healthcare provider may prescribe a different dose or increase it more slowly based on your blood pressure, age, other medications, and overall health.

Maintenance Dose

Once your blood pressure is controlled, your healthcare provider will adjust the dose to the lowest amount that continues to work effectively.

The maintenance dose is different for each patient. Some people need smaller doses, while others require a higher total daily amount.

Using the lowest effective dose may help reduce the risk of side effects during long-term treatment.

Dividing the Daily Dose

Hydralazine does not remain active in the body for an entire day after one tablet. This is why it is often taken in divided doses.

If you take it four times daily, your healthcare provider or pharmacist can help you create a practical schedule. Try to space the doses evenly while following the times shown on your prescription label.

Do not take doses too close together unless specifically instructed.

Dosage for Heart Failure

When hydralazine is used for heart failure, it is commonly combined with a nitrate medication and other heart failure treatments.

The dose and schedule used for heart failure may be different from the standard schedule used for high blood pressure.

Follow the instructions from your heart specialist. Do not substitute separate medications or change combination doses without medical guidance.

Older Adults

Older adults may be more sensitive to dizziness, low blood pressure, or changes in heart rate.

A healthcare provider may begin with a lower dose and increase it more carefully. Kidney, liver, and heart function may also be considered when selecting the dose.

Monitoring Blood Pressure

Check your blood pressure as directed by your healthcare provider.

Keep a record of your readings, including the time they were taken and whether you had symptoms such as dizziness, headache, or weakness.

Do not adjust your medication based on a single blood-pressure reading unless your healthcare provider has given you specific instructions.

Low Blood Pressure

Apresoline may sometimes lower blood pressure too much, especially when treatment begins or the dose is increased.

Possible symptoms include:

  • Dizziness
  • Light-headedness
  • Weakness
  • Blurred vision
  • Fainting

Stand up slowly from a sitting or lying position. Contact your healthcare provider if these symptoms are severe or persistent.

Rapid Heartbeat

The body may respond to widened blood vessels by making the heart beat faster.

Your healthcare provider may prescribe a beta-blocker or another heart medication to control this effect.

Contact your healthcare provider if you develop a persistent rapid or pounding heartbeat, chest discomfort, severe dizziness, or fainting.

Fluid Retention

Hydralazine may sometimes cause the body to retain salt and water.

A diuretic, also called a water pill, may be prescribed to help prevent or control fluid buildup.

Contact your healthcare provider if you develop swelling in the legs or ankles, sudden weight gain, or worsening shortness of breath.

Missed Dose

Take a missed dose as soon as you remember.

However, skip it if it is almost time for your next scheduled dose. Take your next dose at the regular time.

Do not take two doses at once or take extra tablets to replace a missed dose.

Accidental Overdose

Taking too much Apresoline may cause dangerously low blood pressure, a rapid heartbeat, severe headache, dizziness, fainting, or chest pain.

Contact a poison control center or seek emergency medical care immediately if you take more than prescribed.

Continuing Treatment

Continue taking Apresoline even if you feel well. High blood pressure often does not cause noticeable symptoms.

Do not stop taking the medication suddenly or change your dose without speaking with your healthcare provider. Your blood pressure or heart failure symptoms may worsen if treatment is interrupted.

Regular Medical Monitoring

Your healthcare provider may monitor:

  • Blood pressure
  • Heart rate
  • Swelling and body weight
  • Kidney function
  • Blood-cell counts
  • Heart failure symptoms
  • Signs of medication-related lupus

Attend all scheduled appointments and laboratory tests so the dose can be adjusted safely.

Common Side Effects of Apresoline (Hydralazine):

  • Chest pain
  • Fast heart rate
  • Headache
  • Vomiting
  • Diarrhea
  • Loss of appetite

Serious Side Effects of Apresoline (Hydralazine):

  • Allergic reactions:
    • Skin rash
    • Itching
    • Hives
    • Swelling of the face
    • Lips
    • Tongue
    • Throat
  • Heart attack:
    • Pain or tightness in the chest, shoulders, arms, or jaw
    • Nausea
    • Shortness of breath
    • Cold or clammy skin
    • Feeling faint or lightheaded
  • Low blood pressure:
    • Dizziness
    • Feeling faint or lightheaded
    • Blurry vision
  • Lupus-like syndrome:
    • Joint pain, swelling, or stiffness
    • Butterfly-shaped rash on the face
    • Rashes that get worse in the sun, fever
    • Unusual weakness or fatigue
  • Pain, tingling, or numbness in the hands or feet

Apresoline (Hydralazine) is available in the following forms and strengths:

Hydralazine: Tablet

  • 10 mg
  • 25 mg
  • 50 mg

Blood Pressure Monitoring

Check your blood pressure regularly as directed by your healthcare provider.

Keep a record of your readings and bring it to your medical appointments. Your healthcare provider may adjust your dose based on your blood pressure, symptoms, and response to treatment.

Do not change your dose on your own.

Allergic Reactions

Do not take Apresoline if you are allergic to hydralazine or any other ingredient in the product.

Apresoline does not contain hydrochlorothiazide unless it is part of a separate combination product.

Stop taking the medication and seek immediate medical care if you develop:

  • Hives or a severe rash
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe dizziness or fainting

Pregnancy

Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant.

Hydralazine may be used during pregnancy in certain situations, particularly when high blood pressure requires treatment. Your healthcare provider will consider the benefits and possible risks before recommending it.

Do not start or stop Apresoline during pregnancy without medical guidance.

Medical History

Before taking Apresoline, tell your healthcare provider about all medical conditions you have.

Be sure to mention if you have:

  • Kidney disease
  • Liver disease
  • Lupus or another autoimmune condition
  • A history of stroke
  • Chest pain
  • Heart disease
  • Low blood pressure
  • A rapid or irregular heartbeat

These conditions may affect whether Apresoline is appropriate or whether closer monitoring is needed.

Coronary Artery Disease

Apresoline may increase the heart rate and make the heart work harder.

It may not be suitable for people with coronary artery disease because it can worsen chest pain or increase the risk of heart-related complications.

Seek immediate medical care if you develop severe chest pain, shortness of breath, fainting, or a rapid or irregular heartbeat.

Rheumatic Mitral Valve Disease

Apresoline may not be suitable for people with rheumatic heart disease affecting the mitral valve.

Tell your healthcare provider if you have a heart valve condition. They will determine whether another blood pressure treatment is safer and more appropriate.

What Is Apresoline Used For?

Apresoline contains hydralazine, a medication used to lower high blood pressure. It relaxes and widens the arteries, making it easier for blood to flow. Lowering blood pressure may reduce the risk of stroke, heart attack, heart failure, and kidney damage. Hydralazine may also be used in hospitals to treat dangerously high blood pressure. In certain situations, it may be given to manage severe high blood pressure during pregnancy, including cases associated with pre-eclampsia or eclampsia.

What Is the Best Time to Take Hydralazine?

Take hydralazine at the times prescribed by your healthcare provider. It is often taken several times daily because its effects do not usually last for a full 24 hours. Space the doses as evenly as possible and take them at approximately the same times each day. Hydralazine may be taken with or without food, but take every dose consistently in the same way. There is no general rule that the last dose must be taken before 6 p.m.

Can Hydralazine Be Taken Every Day?

Yes. Hydralazine may be taken every day when prescribed for ongoing blood pressure control or heart failure. Continue taking it regularly, even if you feel well. High blood pressure often does not cause noticeable symptoms. Do not stop treatment or change your dose without speaking with your healthcare provider.

When Should Hydralazine Not Be Taken?

Do not take hydralazine if you are allergic to it or any ingredient in the medication. It may also be unsuitable for people with coronary artery disease or rheumatic heart disease affecting the mitral valve. Tell your healthcare provider if you have chest pain, heart disease, a previous heart attack, or a heart valve condition. Kidney or liver disease does not always prevent hydralazine use, but closer monitoring or dose adjustments may be needed. Hydralazine is not automatically prohibited during pregnancy. It may be prescribed when a healthcare provider determines that the expected benefit is greater than the possible risk. Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

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Additional Information Book
Generic name:

Hydralazine

Formulation:

Tablet

Strength(s):

10mg, 25mg, 50mg

Quantities Available:

100

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Apresoline can I order at once from a Canadian pharmacy?

When ordering Apresoline (hydralazine) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is standard for prescription medications to ensure continuous management of conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Apresoline is commonly prescribed in dosages of 10 mg, 25 mg and 50 mg, taken multiple times per day depending on the individual’s condition and response to treatment. For a 90-day supply, the quantity you would order depends on your prescribed dosage:

For example, if prescribed 25 mg tablets to be taken 3 times daily, for a 90-day supply, you would order approximately 270 tablets (90 days x 3 tablets per day).

Do you sell hydralazine?

Yes, we sell hydralazine. You can enjoy low prices on this medication through our website. To purchase hydralazine, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely and appropriately. You have the option to conveniently submit your prescription by mailing it, faxing it, or uploading it through your secure online account.

Do you offer shipping of Apresoline (hydralazine) to the United States?

Yes, we ship Apresoline (hydralazine) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Apresoline (Hydralazine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Apresoline (Hydralazine).