Stomach Ulcers and Bleeding
Anaprox DS can cause serious stomach or intestinal problems, including:
- Ulcers
- Bleeding
- Perforation
These problems can happen without warning.
The risk is higher if you are older, have had stomach ulcers or gastrointestinal bleeding before, take blood thinners or corticosteroids, or use Anaprox DS for a long time.
Seek medical attention right away if you notice black stools, vomiting blood, or severe stomach pain.
Heart Attack and Stroke Risk
Anaprox DS can increase the risk of serious cardiovascular problems, including heart attack and stroke.
This risk may begin early in treatment and can increase with longer use.
Tell your healthcare provider if you have heart disease, high blood pressure, or other cardiovascular risk factors.
Anaprox DS should not be used around the time of coronary artery bypass graft, or CABG, surgery.
Kidney Problems
Naproxen can reduce kidney function, especially in people who already have kidney disease, are dehydrated, are older, or take certain blood pressure medications or diuretics.
Naproxen products are generally not recommended in people with creatinine clearance below 30 mL/min.
Your healthcare provider may check your kidney function during treatment.
Older Adults
Older adults may be more sensitive to some of the serious side effects of Anaprox DS, especially stomach bleeding and kidney problems.
The lowest effective dose should be used for the shortest possible time.
Pregnancy
Tell your healthcare provider if you are pregnant or planning to become pregnant.
NSAIDs such as naproxen should generally be avoided from about 20 weeks of pregnancy onward unless specifically recommended by a healthcare provider.
Do not use Anaprox DS in the third trimester, because NSAIDs can cause serious problems for the developing baby.
Aspirin or NSAID Allergy
Do not take Anaprox DS if you have previously developed asthma, hives, or another allergic reaction after taking aspirin or another NSAID.
A serious allergic reaction can occur.
Seek emergency medical attention if you develop swelling, wheezing, hives, or difficulty breathing.
Asthma
Tell your healthcare provider if you have asthma.
People with aspirin-sensitive asthma may have a serious reaction to naproxen and should not use it.
Other people with asthma may also need closer monitoring.
Drug Interactions
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and supplements you take.
Anaprox DS may interact with:
- Blood thinners
- Aspirin
- Other NSAIDs
- Corticosteroids
- Diuretics
- ACE inhibitors
- Angiotensin receptor blockers (ARBs)
- Lithium
- Methotrexate
Some combinations may increase the risk of bleeding, kidney problems, or other side effects.
Increased Bleeding Risk
Anaprox DS can affect how platelets work and may make bleeding more likely.
If you take a blood thinner or another medication that increases bleeding risk, use Anaprox DS only under the guidance of your healthcare provider.
Dizziness or Drowsiness
Some people may feel dizzy or drowsy while taking Anaprox DS.
Do not drive, operate machinery, or do anything that requires alertness until you know how the medication affects you.
Stomach Upset
Anaprox DS may be taken with food or milk if it causes stomach upset.
However, taking it with food does not completely prevent ulcers or gastrointestinal bleeding.
Use the Lowest Effective Dose
Take Anaprox DS exactly as prescribed.
Use the lowest effective dose for the shortest amount of time needed to control your symptoms.
Do not increase your dose or take it more often without speaking with your healthcare provider.
When to Contact Your Healthcare Provider
Seek medical attention if you develop chest pain, trouble breathing, black stools, vomiting blood, severe stomach pain, severe swelling, reduced urination, or signs of an allergic reaction while taking Anaprox DS.
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