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Tecfidera (Dimethyl fumarate) Shopper Approved

Prescription Prescription Required FormationFormulation: Delayed Release Capsule

Tecfidera

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Prescription Prescription Required FormationFormulation: Delayed Release Capsule

Dimethyl fumarate

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Tecfidera contains the active ingredient dimethyl fumarate. It is a prescription medication used to treat certain forms of multiple sclerosis (MS).

Relapsing Forms of Multiple Sclerosis

Tecfidera is used to treat relapsing forms of multiple sclerosis.

MS is a condition in which the immune system mistakenly attacks the protective covering around nerves in the brain and spinal cord.

This damage can interfere with communication between the brain and the rest of the body.

Tecfidera may help:

  • Reduce the number of MS relapses
  • Lower disease activity seen on MRI scans
  • Slow the progression of disability in some people

Tecfidera does not cure multiple sclerosis, but it can help control disease activity over time.

How Tecfidera Works

Tecfidera belongs to a group of medications called fumarates.

Its exact mechanism in multiple sclerosis is not completely understood.

Dimethyl fumarate is rapidly converted in the body to an active substance called monomethyl fumarate.

This active form is believed to affect several pathways involved in inflammation and protection from cellular stress.

Anti-Inflammatory Effects

Tecfidera may help reduce the activity of immune cells and inflammatory signals that can damage nerves in people with MS.

By lowering inflammation, the medication may help reduce new areas of MS-related damage.

Neuroprotective Effects

Tecfidera is also thought to activate cellular pathways that help protect nerve cells from oxidative stress.

Oxidative stress can contribute to damage in the nervous system.

These protective effects may help explain how Tecfidera reduces disease activity in multiple sclerosis.

Long-Term Treatment

Tecfidera is generally used as a long-term disease-modifying therapy.

It is not intended to treat an acute MS relapse immediately.

Your healthcare provider will monitor your symptoms, blood tests, and overall response to treatment to determine whether Tecfidera continues to be appropriate for you.

Tecfidera is a delayed-release capsule taken by mouth twice daily.

It can be taken with or without food. However, taking Tecfidera with food may help reduce flushing, a common side effect.

Swallow the Capsule Whole

Swallow Tecfidera capsules whole and intact.

Do not:

  • Crush the capsules
  • Chew the capsules
  • Open the capsules
  • Sprinkle the capsule contents on food

The delayed-release formulation is designed to release the medication properly after it is swallowed.

Starting Dose

Starting dose: 120 mg twice daily for the first 7 days.

Maintenance Dose

After 7 days, the dose is increased to:

Maintenance dose: 240 mg twice daily.

Try to take your doses at approximately the same times each day to help maintain a consistent treatment schedule.

If You Have Trouble Tolerating the Maintenance Dose

If side effects make the 240 mg twice-daily dose difficult to tolerate, your healthcare provider may temporarily reduce the dose to 120 mg twice daily.

The recommended maintenance dose of 240 mg twice daily should generally be restarted within 4 weeks if tolerated.

If you are unable to return to the recommended maintenance dose, your healthcare provider may consider stopping Tecfidera.

Managing Flushing

Flushing may cause warmth, redness, itching, or a burning sensation.

Taking Tecfidera with food may help reduce how often flushing occurs or how severe it becomes.

Do not take aspirin specifically for flushing unless your healthcare provider recommends it, as aspirin may not be appropriate for everyone.

Take Tecfidera Regularly

Take Tecfidera exactly as prescribed, even when you are feeling well.

Tecfidera is used as a long-term disease-modifying treatment for multiple sclerosis, so taking it consistently is important for maintaining its effect.

Do not increase, decrease, or stop your dose without first speaking with your healthcare provider.

What to Do If You Miss a Dose

If you miss a dose, take it when you remember unless it is almost time for your next scheduled dose.

If your next dose is approaching, skip the missed dose and continue with your regular schedule.

Do not take two doses at the same time to make up for a missed dose.

Follow Your Healthcare Provider’s Instructions

Your healthcare provider may monitor blood tests and your overall response to Tecfidera during treatment.

Contact your healthcare provider if side effects become difficult to manage or if you develop new or worsening symptoms.

Common Side Effects of Tecfidera (Dimethyl Fumarate):

  • Nausea
  • Flushing
  • Redness
  • Itching
  • Indigestion
  • Headache
  • Vomiting

Serious Side Effects of Tecfidera (Dimethyl Fumarate):

  • Burning
  • Changes in your thinking, memory, walking, balance, speech, eyesight, or strength
  • Clumsiness of the arms or legs
  • Confusion
  • Dark urine
  • Extreme tiredness
  • Fever
  • Hives
  • Rash
  • Difficulty swallowing or breathing
  • Hoarseness
  • Itching
  • Loss of appetite
  • Neck stiffness
  • Pain in the upper right side of your stomach
  • Persistent vomiting
  • Severe stomach pain
  • Signs of an infection (fever, chills, persistent sore throat)
  • Signs of brain infection or progressive multifocal leukoencephalopathy (clumsiness, loss of coordination, weakness, mental changes)
  • Skin sensitivity on one side of the body or face
  • Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • Tingling
  • Weakness on one side of the body that worsens over time
  • Yellowing of the skin or eyes

Tecfidera (Dimethyl Fumarate) is available in the following forms and strengths:

Tecfidera: Delayed Release Capsule

  • 120 mg
  • 240 mg

Dimethyl Fumarate: Delayed Release Capsule

  • 240 mg

Allergic Reactions

Do not take Tecfidera if you are allergic to dimethyl fumarate or any ingredient in the capsules.

Serious allergic reactions, including anaphylaxis and angioedema, can occur.

Seek immediate medical attention if you develop:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Hives or a severe rash
  • Severe dizziness
  • Widespread itching

If a serious allergic reaction occurs, Tecfidera should be stopped and medical care should be sought right away.

Low Lymphocyte Counts

Tecfidera can lower the number of lymphocytes, a type of white blood cell that helps the body fight infections.

Tell your healthcare provider if you already have a low lymphocyte count or a condition that affects your immune system.

Blood tests are usually performed before treatment and periodically while you are taking Tecfidera.

If lymphocyte levels become too low or remain low for a long time, your healthcare provider may need to interrupt or stop treatment.

Risk of Infection

Because Tecfidera can lower lymphocyte levels, it may increase the risk of certain infections.

The risk may be higher if Tecfidera is taken with other medications that suppress the immune system or lower white blood cell counts.

Contact your healthcare provider if you develop symptoms of infection such as fever, chills, persistent cough, unusual weakness, or other new symptoms.

Flushing

Flushing is a common side effect of Tecfidera, especially when treatment is first started.

Symptoms may include:

  • Warmth
  • Redness
  • Itching
  • Burning or tingling of the skin

Flushing is often mild to moderate and may improve over time.

Taking Tecfidera with food may help reduce flushing.

Progressive Multifocal Leukoencephalopathy

A rare but serious brain infection called progressive multifocal leukoencephalopathy (PML) has been reported in people taking Tecfidera.

The risk may be greater in people with prolonged low lymphocyte counts.

Contact your healthcare provider immediately if you develop new or worsening neurological symptoms, such as:

  • Weakness on one side of the body
  • Vision changes
  • Problems with coordination
  • Difficulty speaking
  • Confusion
  • Changes in thinking or personality

These symptoms require prompt medical evaluation.

Other Medications That Affect the Immune System

Tell your healthcare provider about all medications you are taking, especially treatments that can suppress the immune system or reduce white blood cell counts.

Using multiple immune-suppressing medications together may increase the risk of infection.

Do not start or stop another medication without checking with your healthcare provider first.

How long can I take Tecfidera?

Tecfidera may be used as a long-term treatment for multiple sclerosis. You can usually continue taking it for as long as it is helping control your MS and you are not experiencing serious or unacceptable side effects. Your healthcare provider will monitor your symptoms, blood tests, and overall response to treatment to determine whether Tecfidera should be continued.

When is the best time to take Tecfidera?

Tecfidera is usually taken twice daily, with the doses spaced throughout the day. Many people take one dose in the morning and the second dose later in the day or evening. Try to take Tecfidera at about the same times each day. It may be taken with or without food, although taking it with food can help reduce flushing or stomach-related side effects.

Is hair loss a side effect of Tecfidera?

Hair loss is not considered a common side effect of Tecfidera. However, there have been occasional reports of hair thinning or hair loss in people taking dimethyl fumarate. In some reported cases, the hair grew back even while treatment was continued. Hair loss can also have many other causes, including stress, nutritional deficiencies, thyroid problems, hormonal changes, and other medications. If you notice significant or persistent hair loss while taking Tecfidera, speak with your healthcare provider so the possible cause can be evaluated.

REVIEWS

Additional Information Book
Generic name:

Dimethyl fumarate

Formulation:

Capsule, Delayed Release Capsule

Strength(s):

120mg, 240mg

Quantities Available:

56, 90

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Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Tecfidera can I order at once from a Canadian pharmacy?

When ordering Tecfidera (dimethyl fumarate) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Tecfidera is commonly prescribed in dosages of 120 mg or 240 mg, taken twice daily. For a 90-day supply, this means you would order 180 capsules (90 days x 2 capsules per day).

Do you sell dimethyl fumarate?

Yes, we sell dimethyl fumarate on our website. You can enjoy low prices when you order through us. To purchase dimethyl fumarate, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Tecfidera (dimethyl fumarate) to the United States?

Yes, we ship Tecfidera (dimethyl fumarate) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Tecfidera (Dimethyl fumarate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Tecfidera (Dimethyl fumarate).