Low blood pressure and dizziness
Rytary may cause a sudden drop in blood pressure when you stand up after sitting or lying down. This is called orthostatic hypotension and may cause dizziness, lightheadedness, fainting, or falls.
The risk may be greater when you first begin treatment or after your dose is increased. Older adults may also be more vulnerable to falls. Stand up slowly and hold onto something stable until you know how the medication affects you.
Contact your healthcare provider if you frequently feel dizzy, faint, or unsteady.
Hallucinations and changes in thinking
Rytary may cause hallucinations, confusion, agitation, unusual dreams, or difficulty distinguishing what is real. Hallucinations may involve seeing, hearing, or feeling things that are not present.
These effects may be more likely shortly after treatment begins or after the dose is increased. Older adults and people with a history of certain psychiatric conditions may have a greater risk.
Tell your healthcare provider promptly about hallucinations, severe confusion, suspicious thoughts, agitation, aggressive behaviour, or other significant changes in thinking or behaviour. Rytary is generally not recommended for people with a major psychotic disorder because it may worsen psychosis.
Involuntary movements
Rytary may cause new involuntary movements or worsen movements that are already present. These uncontrolled movements are called dyskinesias and may affect the face, mouth, arms, legs, or other parts of the body.
Contact your healthcare provider if these movements become troublesome. Your Rytary dose or another Parkinson’s medication may need to be adjusted. Do not change the dose on your own.
Sleepiness and driving
Rytary may cause significant drowsiness. Some people taking medications containing levodopa have fallen asleep suddenly during everyday activities, sometimes without feeling sleepy beforehand.
Do not drive, operate machinery, or perform another potentially dangerous activity until you know how Rytary affects you. Tell your healthcare provider if you experience severe daytime sleepiness or suddenly fall asleep while eating, talking, driving, or completing another activity.
Alcohol and other medications that cause drowsiness may increase this risk.
Medication interactions
Tell your healthcare provider and pharmacist about every prescription medication, over-the-counter product, vitamin, and supplement you take before starting Rytary.
Do not take Rytary with a nonselective monoamine oxidase inhibitor, also called an MAOI, or within two weeks after stopping one. Examples include phenelzine and tranylcypromine. Combining these medications may cause dangerously high blood pressure.
Certain selective MAO-B inhibitors used for Parkinson’s disease may sometimes be prescribed with Rytary, but the combination may increase the risk of low blood pressure when standing. Other medications, including dopamine-blocking antipsychotics, metoclopramide, and some iron supplements, may also affect how well Rytary works or how it is absorbed.
Do not begin, stop, or change another medication without first consulting your healthcare provider.
Medical conditions to discuss with your healthcare provider
Before taking Rytary, tell your healthcare provider about all your medical conditions, particularly heart disease, irregular heart rhythms, glaucoma, a history of hallucinations or psychosis, sleep disorders, or a history of uncontrolled urges or compulsive behaviours.
Also mention any kidney or liver disease, although the effects of these conditions on Rytary have not been fully studied. A history of stomach ulcers, asthma, or another significant medical problem should be discussed so your healthcare provider can determine whether additional monitoring is appropriate.
Changes in mood or behaviour
People with Parkinson’s disease may experience changes in mood or behaviour, and Rytary can sometimes contribute to psychiatric symptoms. Anxiety has been reported during treatment, and suicidal thoughts or attempts have occurred in some patients.
Contact your healthcare provider immediately if you develop new or worsening depression, severe anxiety, suicidal thoughts, hallucinations, unusual behaviour, or major changes in mood.
Some people may also develop intense or uncontrollable urges, such as compulsive gambling, excessive shopping, binge eating, or increased sexual urges. The person taking Rytary may not recognize these changes, so family members and caregivers should also watch for them.
Dark urine, saliva, or sweat
Rytary may cause urine, saliva, or sweat to become darker in colour. This effect is usually harmless, but it may stain clothing or bedding.
Tell your healthcare provider if the colour change occurs with other symptoms, such as painful urination, yellow skin or eyes, severe weakness, or abdominal pain, because these symptoms may have another cause.
Taking Rytary with food
Rytary may be taken with or without food. It does not have to be taken with food, although taking it with a small meal may help reduce nausea for some people.
A high-fat, high-calorie meal may delay the medication’s effect by approximately two to three hours. High-protein foods may also reduce levodopa absorption in some patients.
Try to take Rytary consistently in relation to meals and follow the meal-timing instructions provided by your healthcare provider. Do not completely eliminate protein from your diet unless a qualified healthcare professional advises you to do so.
Glaucoma
Tell your healthcare provider if you have glaucoma or increased pressure inside your eyes. People with chronic wide-angle glaucoma may sometimes use Rytary if their eye pressure is well controlled, but regular monitoring may be needed.
Report eye pain, sudden blurred vision, severe headache, halos around lights, or redness of the eye immediately, as these symptoms require urgent medical attention.
Using Rytary safely
Take Rytary exactly as prescribed. Do not increase, reduce, or suddenly stop the medication without medical guidance.
Contact your healthcare provider about persistent dizziness, fainting, severe sleepiness, uncontrolled movements, hallucinations, unusual urges, or significant changes in mood or behaviour. Seek urgent medical attention for chest pain, sudden loss of consciousness, suicidal thoughts, or a severe reaction involving fever, confusion, and extreme muscle stiffness.
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