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Rapamune contains the active ingredient sirolimus. It is a prescription immunosuppressive medication used to help prevent rejection of a transplanted kidney.
Rapamune is used as part of an immunosuppressive treatment plan in adults who have received a kidney transplant.
After a transplant, the immune system may recognize the new kidney as foreign. Without treatment, immune cells can attack the transplanted organ and interfere with how well it works. This process is called organ rejection.
Rapamune helps reduce this immune response so the transplanted kidney has a better chance of continuing to function.
The immune system is designed to identify and destroy substances that it sees as foreign.
A transplanted kidney comes from another person, so the immune system may recognize proteins on the donor organ as different from the body’s own tissues. This can activate immune cells, especially certain white blood cells called T lymphocytes.
These immune cells can attack the transplanted kidney and cause inflammation and tissue damage.
Immunosuppressive medications such as Rapamune help reduce this immune activity.
Rapamune belongs to a class of medications called immunosuppressants.
Sirolimus works by blocking a protein called mammalian target of rapamycin (mTOR). This protein plays an important role in the growth, activation, and multiplication of certain immune cells.
By blocking mTOR, Rapamune reduces the ability of immune cells to multiply and respond to the transplanted kidney.
This helps:
T cells are an important part of the immune system and play a major role in organ rejection.
Normally, when T cells are activated, they receive signals that tell them to grow and multiply. Sirolimus interferes with these signals.
By limiting T-cell growth and activity, Rapamune helps prevent the immune system from mounting a strong attack against the transplanted kidney.
Rapamune is often used together with other medications that suppress the immune system.
Depending on the treatment plan, these may include:
Using medications that work through different mechanisms can provide stronger protection against rejection.
The exact combination depends on factors such as kidney function, transplant history, risk of rejection, and how well the patient tolerates treatment.
The risk of rejection is often highest during the early period after a kidney transplant, but it can remain present long term.
Rapamune may therefore be used as part of either an early or long-term immunosuppressive treatment plan.
The goal is to use enough medication to prevent rejection while minimizing side effects caused by excessive suppression of the immune system.
The amount of sirolimus in the bloodstream needs to stay within a specific range.
If the level is too low, there may not be enough medication to prevent rejection. If the level becomes too high, the risk of side effects can increase.
For this reason, your healthcare provider may order regular blood tests to measure sirolimus trough levels and adjust your dose when needed.
Rapamune can affect several body systems, so regular follow-up is important.
Your healthcare provider may monitor:
These tests help determine whether treatment is working safely and effectively.
Because Rapamune suppresses the immune system, it can make it harder for the body to fight infections.
Patients may be more likely to develop bacterial, viral, fungal, or other infections while taking the medication.
Contact your healthcare provider if you develop symptoms such as fever, chills, persistent cough, unusual tiredness, or other signs of infection.
Preventing organ rejection often requires long-term immunosuppressive therapy.
Rapamune helps control the immune response but does not permanently eliminate the risk of rejection. It is important to continue taking the medication exactly as prescribed, even if you feel well.
Do not stop Rapamune, skip doses, or change your dose without speaking with your healthcare provider. Suddenly reducing immunosuppression may increase the risk of transplant rejection.
Rapamune is only one part of kidney transplant care.
Long-term management may also include:
Your transplant team will adjust treatment over time based on how well the transplanted kidney is working and how your body responds to immunosuppressive therapy.
Rapamune contains sirolimus and is usually taken by mouth once daily. Take it at about the same time each day to help maintain a consistent amount of medication in your body.
Use Rapamune exactly as prescribed by your healthcare provider. Do not take more or less than prescribed, and do not change your dosing schedule on your own.
Rapamune may be taken with or without food, but it is important to take it the same way every day.
For example, if you usually take Rapamune with food, continue taking it with food. If you take it on an empty stomach, continue taking it that way.
Taking Rapamune consistently in relation to meals helps keep the amount absorbed by your body more predictable.
Swallow Rapamune tablets whole with water.
Do not crush, chew, or split the tablets unless your healthcare provider or pharmacist specifically tells you that your particular product can be handled differently.
If you have difficulty swallowing the tablets, ask your healthcare provider or pharmacist whether another dosage form is appropriate.
If you are taking cyclosporine as part of your transplant treatment, Rapamune is generally taken about 4 hours after your cyclosporine dose.
Taking the medications too close together can increase sirolimus exposure and may raise the risk of side effects.
Follow the exact timing instructions provided by your transplant team, because your immunosuppressive treatment schedule may be individualized.
Take Rapamune every day according to your prescribed schedule, even if you feel well.
Rapamune helps prevent transplant rejection by suppressing the immune system. You may not notice any symptoms when the medication is working, so it is important to continue taking it consistently.
Do not skip doses or stop treatment without speaking with your healthcare provider.
Your Rapamune dose is individualized and may depend on several factors, including:
Your healthcare provider may adjust your dose based on blood tests and other monitoring.
Regular blood tests are important while you are taking Rapamune.
Your healthcare provider may measure the amount of sirolimus in your blood to make sure the level is high enough to prevent rejection but not so high that it increases the risk of side effects.
Do not change your dose based on a blood test result unless your healthcare provider tells you to.
If you miss a dose of Rapamune, contact your healthcare provider, pharmacist, or transplant team for instructions, especially if you are also taking cyclosporine.
Do not take two doses at the same time or take extra medication to make up for a missed dose unless your healthcare provider specifically tells you to.
Because maintaining steady immunosuppressive treatment is important after a transplant, repeated missed doses may increase the risk of organ rejection.
Do not stop taking Rapamune or change your dose without first speaking with your healthcare provider.
Stopping or reducing immunosuppressive treatment on your own may allow your immune system to attack the transplanted kidney and increase the risk of rejection.
Rapamune (Sirolimus) is available in the following forms and strength:
Rapamune is not recommended for preventing rejection after liver or lung transplantation. Serious complications, including increased risk of graft loss and death, have been reported when sirolimus has been used in these types of transplants.
Tell your healthcare provider about your transplant history before starting Rapamune.
Rapamune suppresses the immune system, which can make it harder for your body to fight infections.
Contact your healthcare provider if you develop symptoms such as:
Some infections can become serious in people taking immunosuppressive medications.
Long-term suppression of the immune system may increase the risk of certain cancers, especially lymphoma and skin cancer.
Limit unnecessary sun exposure, avoid tanning beds, and follow your healthcare provider’s recommendations for sun protection and routine skin examinations.
Tell your healthcare provider if you notice unusual skin changes, new lumps, or enlarged lymph nodes.
If cyclosporine is part of your transplant treatment, Rapamune is generally taken about 4 hours after the cyclosporine dose.
Taking these medications too close together can affect sirolimus levels and increase the risk of side effects.
Follow the exact dosing schedule provided by your transplant team.
Take Rapamune exactly as prescribed. Do not increase, decrease, or stop your dose without speaking with your healthcare provider.
Your dose is based on factors such as your blood sirolimus level, medical condition, other medications, and response to treatment.
Changing your dose on your own may increase the risk of side effects or transplant rejection.
Rapamune can increase cholesterol and triglyceride levels.
Tell your healthcare provider if you already have high cholesterol or high triglycerides. Blood tests may be performed regularly to monitor your lipid levels during treatment.
Your healthcare provider may recommend dietary changes or cholesterol-lowering medication if needed.
Rapamune can cause side effects such as:
Tell your healthcare provider if these effects become severe, persistent, or interfere with your daily activities.
Seek prompt medical attention if you develop serious symptoms such as:
These symptoms may require immediate medical evaluation.
Rapamune can interact with many medications and may change sirolimus levels in the blood.
Tell your healthcare provider about everything you take, including:
Do not start or stop another medication without first checking with your healthcare provider or pharmacist.
Tell your healthcare provider if you are pregnant or planning to become pregnant before taking Rapamune.
Sirolimus may harm a developing fetus. Effective contraception may be recommended before treatment, throughout treatment, and for a period after Rapamune is stopped.
Do not stop Rapamune on your own if you become pregnant. Contact your healthcare provider promptly so your transplant treatment can be reviewed safely.
Yes. Sirolimus is the active ingredient in Rapamune. Sirolimus is also known as rapamycin, which was the original name given to the compound after it was discovered in a soil sample from Easter Island, also known as Rapa Nui.
Rapamune is generally not recommended during pregnancy because sirolimus may harm a developing fetus. Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant while taking Rapamune. Your healthcare provider can review the risks and benefits of your treatment and determine the safest approach. Do not stop Rapamune on your own, especially if you are taking it to prevent transplant rejection.
Yes. Rapamune can interact with many medications, and some interactions may increase or decrease the amount of sirolimus in your blood. These may include certain antibiotics, antifungal medications, seizure medications, other immunosuppressants, some heart or blood pressure medications, and herbal products or supplements. Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use. Do not start or stop another medication without first checking with your healthcare provider or pharmacist.
The length of Rapamune treatment depends on your medical condition, transplant history, response to treatment, and overall immunosuppressive treatment plan. For kidney transplant patients, Rapamune may be used long term to help prevent organ rejection. Some patients may take it for many months or years. Continue taking Rapamune for as long as your healthcare provider recommends. Do not stop treatment suddenly, because this may increase the risk of transplant rejection.
Seizures are not among the most common side effects of Rapamune, but serious neurological problems can occur rarely during immunosuppressive treatment. Seek immediate medical attention if you experience a seizure, loss of consciousness, severe confusion, unusual weakness, or other sudden neurological symptoms while taking Rapamune. Your healthcare provider may need to evaluate whether the symptoms are related to Rapamune, another medication, or another medical condition.
| Generic name: | Sirolimus |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 1mg, 2mg |
| Quantities Available: | 90, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Rapamune (sirolimus) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Rapamune is available in 1 mg tablet. The dosage and quantity prescribed will depend on your healthcare provider’s instructions and your specific medical needs. For example, if you are prescribed 2 mg daily, for a 90-day supply, you would order 180 tablets (90 days x 2 tablets per day).
Yes, we sell sirolimus on our website. You can enjoy low prices when you order through us. To purchase sirolimus, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Rapamune (sirolimus) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Rapamune (Sirolimus). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Rapamune (Sirolimus).
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