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Fluanxol (flupentixol) is a prescription medication used to treat certain mental health conditions, including schizophrenia and, in some countries, depression with or without anxiety.

Fluanxol contains flupentixol, an active ingredient belonging to a class of medications called first-generation or typical antipsychotics.

These medications work mainly by affecting the activity of dopamine, a chemical messenger in the brain involved in thinking, movement, motivation, and emotional responses.

Fluanxol is available in different formulations, including oral tablets and long-acting injections. The conditions it is approved to treat depend on the formulation, dosage, and country.

In Canada, Fluanxol tablets and Fluanxol Depot injections are indicated for maintenance treatment of chronic schizophrenia in patients whose main symptoms do not include severe excitement, agitation, or hyperactivity. In the United Kingdom, low-dose Fluanxol tablets are indicated for the symptomatic treatment of depression with or without anxiety. 

Treatment of Schizophrenia and Other Psychotic Symptoms

Fluanxol is used to help manage symptoms of schizophrenia, a long-term mental health condition that affects how a person thinks, feels, and interprets reality.

Schizophrenia can interfere with everyday activities, communication, concentration, and social functioning.

Some people experience episodes of psychosis, which may involve hallucinations, delusions, or disorganized thinking.

Fluanxol helps reduce certain psychotic symptoms by blocking dopamine receptors in the brain.

The medication may help manage the following symptoms:

  • Hallucinations: Seeing, hearing, or sensing things that are not present. Fluanxol may help reduce the frequency and intensity of hallucinations, including hearing voices.
  • Delusions: Strong beliefs that do not reflect reality, even when evidence suggests otherwise. Fluanxol may help reduce the intensity of these beliefs.
  • Disorganized Thinking: Difficulty organizing thoughts or expressing ideas clearly. Treatment may help improve thought organization as psychotic symptoms decrease.
  • Unusual Behavior: Psychotic symptoms may affect a person’s actions, reactions, and ability to complete daily activities. Fluanxol may help stabilize certain behaviors.
  • Difficulty Maintaining Daily Activities: Managing psychotic symptoms may make it easier to participate in everyday routines and maintain communication with others.

Fluanxol is particularly used for maintenance treatment in certain patients with chronic schizophrenia.

Maintenance treatment involves taking medication regularly to help control symptoms and reduce the risk of another psychotic episode.

Fluanxol Depot is a long-acting injectable formulation that releases medication gradually over time. It may be prescribed when ongoing antipsychotic treatment is needed.

Fluanxol does not cure schizophrenia, but it may help control symptoms and support long-term stability.

Your healthcare provider will determine which formulation and dosage are appropriate based on your symptoms, treatment history, and response to medication.

Treatment of Depression With or Without Anxiety

In certain countries, low-dose Fluanxol tablets are used to treat symptoms of depression, including depression accompanied by anxiety.

Depression is a condition that can affect mood, energy, motivation, concentration, sleep, and everyday functioning.

Some people with depression also experience anxiety, which may cause excessive worry, nervousness, tension, or difficulty relaxing.

Low-dose flupentixol has different clinical uses from the higher doses prescribed for schizophrenia.

When prescribed for depressive symptoms, Fluanxol may help improve certain aspects of mood and emotional functioning.

Symptoms that may improve with appropriate treatment include:

  • Persistent Low Mood: Ongoing feelings of sadness or emotional distress.
  • Reduced Motivation: Difficulty finding the energy or interest to complete everyday activities.
  • Loss of Interest: Reduced enjoyment in activities that were previously rewarding.
  • Anxiety and Nervousness: Feelings of worry, tension, or uneasiness that accompany depression.
  • Low Energy: Persistent tiredness or reduced activity associated with depressive symptoms.
  • Difficulty Concentrating: Trouble focusing, making decisions, or maintaining attention.

The exact way low-dose flupentixol affects depressive symptoms is not fully understood.

It is thought to involve changes in dopamine signaling in areas of the brain associated with motivation and emotional functioning.

However, Fluanxol is not appropriate for every type of depression. It is not a standard first-line antidepressant in many countries, and its approved use varies by region.

Your healthcare provider will consider the severity of your symptoms, medical history, and available treatment options before prescribing it.

How Does Fluanxol Work?

Fluanxol contains flupentixol, a typical antipsychotic medication from a chemical class known as thioxanthenes.

Flupentixol affects neurotransmitters, which are chemical messengers that allow nerve cells to communicate.

One of its main targets is dopamine, a neurotransmitter involved in movement, motivation, emotional responses, and thinking.

Dopamine works by attaching to specific receptors on nerve cells, allowing signals to pass between different parts of the brain.

Fluanxol changes dopamine signaling by blocking certain dopamine receptors.

Its effects depend partly on the dose and the brain pathways involved.

Blocks Dopamine D2 Receptors

Flupentixol primarily works by blocking dopamine D2 receptors in the brain.

These receptors help regulate how nerve cells respond to dopamine.

In some people with schizophrenia, excessive dopamine activity in certain brain pathways is associated with psychotic symptoms, including hallucinations and delusions.

By blocking D2 receptors, Fluanxol reduces the effects of dopamine in these pathways.

This can help decrease psychotic symptoms and improve symptom control during ongoing treatment.

However, dopamine also plays an important role in controlling movement.

Because Fluanxol blocks dopamine receptors, it may cause movement-related side effects, including muscle stiffness, tremors, restlessness, or involuntary movements.

Your healthcare provider will monitor your response to treatment and adjust your medication when necessary.

Helps Control Psychotic Symptoms

Psychotic symptoms can affect how a person understands and responds to their surroundings.

Changes in dopamine signalling are believed to contribute to some of these symptoms.

By reducing dopamine activity in certain brain pathways, Fluanxol may help decrease hallucinations, delusions, and disorganized thinking.

As symptoms become more manageable, some people may find it easier to maintain daily routines and communicate with others.

However, the medication does not work equally well for every symptom of schizophrenia.

Some symptoms, such as reduced emotional expression or lack of motivation, may be more difficult to treat.

Affects Dopamine Activity at Lower Doses

At lower doses, flupentixol may have different effects on dopamine signaling than it does at higher antipsychotic doses.

Researchers have proposed that low-dose flupentixol may influence presynaptic dopamine receptors, potentially changing the release of dopamine between nerve cells.

These effects may contribute to its use for depressive symptoms in countries where low-dose Fluanxol is approved for that purpose.

However, the exact mechanism responsible for its effects on depression has not been fully established.

Fluanxol should not be considered interchangeable with other antidepressants or antipsychotics.

Supports Long-Term Symptom Management

For people receiving treatment for chronic schizophrenia, Fluanxol may help maintain symptom control over time.

Regular treatment helps maintain medication exposure and may reduce the likelihood of symptoms returning.

Long-acting Fluanxol Depot injections provide a gradual release of flupentixol, reducing the need for daily oral medication in selected patients.

Your healthcare provider will determine whether tablets or injections are more suitable for your treatment needs.

How Long Does Fluanxol Take to Work?

The time needed to notice improvement with Fluanxol depends on the condition being treated, dosage, formulation, and individual response.

Some people may notice changes in certain symptoms within the first several days or weeks.

However, the full antipsychotic effects may take several weeks to become apparent.

For schizophrenia, symptoms such as hallucinations and delusions may gradually improve as treatment continues.

When low-dose Fluanxol is prescribed for depression, the time needed for symptom relief may differ.

Your healthcare provider will assess your response and determine whether the prescribed treatment is effective.

Do not increase your dosage or stop taking Fluanxol suddenly without medical advice.

Stopping antipsychotic treatment without an appropriate plan may cause withdrawal symptoms or increase the risk of symptoms returning.

Important Information About Fluanxol

Fluanxol may cause side effects, including restlessness, muscle stiffness, tremors, drowsiness, sleep disturbances, and involuntary movements.

Long-term treatment may also cause a movement disorder called tardive dyskinesia, which involves repetitive, involuntary movements that can sometimes persist after stopping medication.

Tell your healthcare provider if you have a history of heart rhythm problems, seizures, Parkinson’s disease, or other significant medical conditions.

Fluanxol is not approved for treating dementia-related psychosis in older adults, and antipsychotic medications may increase serious health risks in this population.

Fluanxol helps manage certain symptoms of schizophrenia by changing dopamine activity in the brain. Low-dose tablets may also be used for depression with or without anxiety in countries where this indication is approved.

Fluanxol is a prescription medication used to manage certain symptoms of schizophrenia and, in some countries, depression with or without anxiety.

Fluanxol belongs to a class of medications called typical antipsychotics. It works mainly by blocking dopamine receptors in the brain, helping regulate dopamine activity and reduce certain psychotic symptoms.

Fluanxol is available as oral tablets that are taken by mouth. The dosage and treatment schedule depend on the condition being treated, the severity of your symptoms, and your response to the medication.

Always take Fluanxol exactly as prescribed by your healthcare provider. Do not increase your dosage, take additional tablets, or stop treatment without medical advice.

How to Take Fluanxol Tablets Correctly

Follow these general instructions when taking Fluanxol:

  1. Follow your prescribed dosage: Take the amount of Fluanxol recommended by your healthcare provider. Your dosage may change depending on your symptoms and response to treatment.
  2. Swallow the tablet with water: Take Fluanxol by mouth with a glass of water. Avoid crushing or splitting the tablet unless your pharmacist confirms that doing so is appropriate.
  3. Take the medication at scheduled times: Fluanxol may be prescribed once daily or in divided doses, depending on your condition and dosage.
  4. Maintain a consistent routine: Try to take your medication at approximately the same time each day. This can help you remember your doses and maintain consistent medication levels.
  5. Follow dosage adjustments carefully: Your healthcare provider may gradually increase or decrease your dosage based on your symptoms and any side effects.
  6. Monitor your response to treatment: Tell your healthcare provider if your symptoms do not improve or if you develop unusual side effects.
  7. Continue treatment as prescribed: Do not stop taking Fluanxol simply because you feel better. Your symptoms may return if the medication is discontinued too soon.
  8. Attend regular medical appointments: Your healthcare provider may recommend follow-up visits to assess treatment effectiveness and monitor for unwanted effects.

Recommended Dosage of Fluanxol Tablets

The recommended dosage of Fluanxol depends on the condition being treated.

For adults receiving Fluanxol tablets for schizophrenia, the Canadian product monograph recommends an initial dosage of 1 mg taken three times daily.

Your healthcare provider may gradually increase the dosage if your symptoms are not adequately controlled.

When necessary, the dose may be increased by 1 mg every 2 to 3 days until an effective response is achieved.

The usual maintenance dosage is 3 mg to 6 mg daily, taken in divided doses. Some patients may require higher doses under specialist supervision.

Treatment stage Typical adult dosage for schizophrenia
Starting dosage 1 mg three times daily
Dosage adjustment May increase by 1 mg every 2–3 days if necessary
Maintenance dosage 3–6 mg daily in divided doses

These recommendations apply to the Canadian oral treatment regimen for schizophrenia and should not be used as general dosing instructions for depression. 

Dosage for Depression With or Without Anxiety

In countries where low-dose Fluanxol tablets are approved for depression, the dosing schedule is different.

For example, UK prescribing information recommends a starting dose of 1 mg once daily in the morning for adults.

If necessary, the dosage may be increased after one week. The maximum recommended daily dose for this indication is generally 3 mg.

Older adults may require lower starting and maintenance doses.

Your healthcare provider will determine the correct dosage for your specific condition.

Do not use the schizophrenia dosing schedule to treat depression unless it has been specifically prescribed for you. 

Important Tips When Taking Fluanxol

Take Fluanxol at the Same Time Each Day

Taking Fluanxol consistently helps maintain stable medication exposure.

If your healthcare provider prescribes several daily doses, try to space them according to your treatment schedule.

For patients taking low-dose Fluanxol for depression, the medication is commonly administered in the morning.

Fluanxol may cause sleep disturbances or restlessness in some people, particularly when treatment begins.

Tell your healthcare provider if you experience difficulty sleeping or unusual daytime drowsiness. Your dosing schedule may need to be reviewed.

Follow Dosage Adjustments Carefully

Your healthcare provider may adjust your Fluanxol dosage gradually to find the amount that controls your symptoms while minimizing side effects.

Increasing the dosage too quickly may raise the risk of restlessness, tremors, muscle stiffness, dizziness, or other unwanted reactions.

Do not increase your dosage because your symptoms have not improved immediately.

Some symptoms may begin to improve within days, while others may require several weeks of consistent treatment.

If Fluanxol does not adequately control your symptoms, your healthcare provider may adjust your medication or recommend a different treatment.

Avoid Alcohol During Treatment

Alcohol may increase certain side effects of Fluanxol, including dizziness, drowsiness, and impaired concentration.

Combining alcohol with Fluanxol may also affect your coordination and ability to perform tasks that require alertness.

Avoid drinking alcohol during treatment unless your healthcare provider specifically advises otherwise.

Do not drive or operate heavy machinery until you know how Fluanxol affects you.

What Should I Do If I Miss a Dose?

If you forget to take Fluanxol, take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose.

If your next dose is approaching, skip the missed tablet and continue with your regular treatment schedule.

Do not take two doses together to make up for a missed dose.

Taking extra medication may increase the risk of side effects, including dizziness, excessive drowsiness, abnormal muscle movements, or heart rhythm problems.

If you miss several doses or are unsure how to restart treatment, contact your healthcare provider or pharmacist.

Can I Stop Taking Fluanxol Suddenly?

Do not stop taking Fluanxol suddenly without consulting your healthcare provider.

Fluanxol affects dopamine signaling in the brain. When you take the medication regularly, your body adjusts to its effects.

Stopping treatment abruptly may cause withdrawal symptoms or allow the condition being treated to return.

Possible withdrawal symptoms include:

  • Nausea and Vomiting: You may experience an upset stomach or episodes of vomiting.
  • Diarrhea: Changes in bowel movements may occur after stopping treatment.
  • Difficulty Sleeping: You may experience insomnia or disrupted sleep.
  • Loss of Appetite: Your appetite may temporarily decrease.
  • Restlessness: You may feel unusually unsettled or agitated.
  • Sweating: Some people may experience increased perspiration.
  • Return of Symptoms: Hallucinations, delusions, depression, or other symptoms may return or become worse.

Withdrawal symptoms can vary depending on your dosage, treatment duration, and individual response.

If you need to discontinue Fluanxol, your healthcare provider may recommend gradually reducing the dosage.

This process is called dose tapering.

Gradual dosage reductions allow your body time to adjust and may help reduce withdrawal symptoms.

The tapering schedule depends on how long you have taken Fluanxol, your current dosage, and the reason for stopping treatment.

Do not reduce or discontinue Fluanxol on your own. Your healthcare provider can develop a treatment plan that reduces the risk of withdrawal symptoms and symptom recurrence.

How Long Does Fluanxol Take to Work?

The time needed to notice improvement depends on the condition being treated and your individual response.

Some people may notice changes in certain symptoms within the first few days of treatment.

However, improvements in schizophrenia symptoms, including hallucinations and delusions, may develop gradually over several weeks.

For depression, the time needed to notice improvement may differ depending on the dosage and severity of symptoms.

Your healthcare provider will assess your response during follow-up appointments and determine whether dosage adjustments are necessary.

Do not take additional medication to make Fluanxol work faster.

When to Contact Your Healthcare Provider

Contact your healthcare provider if you experience persistent dizziness, severe restlessness, unusual muscle stiffness, tremors, involuntary movements, or significant sleep disturbances during treatment.

You should also seek medical advice if your symptoms become worse or return after a dosage adjustment.

Seek emergency medical attention if you develop a high fever with severe muscle stiffness, confusion, or significant changes in consciousness. These symptoms may indicate a rare but serious reaction called neuroleptic malignant syndrome.

Fluanxol may also cause serious heart rhythm problems in susceptible individuals. Seek urgent medical evaluation if you experience fainting or a rapid, irregular heartbeat.

Always take Fluanxol according to your healthcare provider’s instructions. Following the prescribed dosage, making adjustments only under medical supervision, and avoiding sudden discontinuation can help maintain symptom control while reducing the risk of unwanted effects.

Common Side Effects of Fluanxol (Flupenthixol):

  • Changes in menstrual periods
  • Constipation
  • Decreased interest in sexual activity
  • Decreased sexual ability
  • Dizziness
  • Dry mouth
  • Fatigue
  • Increased production of saliva
  • Increased sensitivity of the skin to sunlight
  • Increased sweating
  • Swelling of breasts (in men and women)
  • Unusual secretion of milk
  • Weight changes

Serious Side Effects of Fluanxol (Flupenthixol):

  • Abdominal pain
  • Blurred vision or other eye problems
  • Chewing movements
  • Circular eye movement
  • Dark urine
  • Difficult urination
  • Difficulty breathing
  • Excessive eating
  • Fast, pounding, or irregular heartbeat
  • Frequent urination
  • Increased thirst
  • Infections, fruity breath odor
  • Lip smacking or puckering
  • Loss of appetite
  • Mask-like face
  • Muscle spasms, especially of the neck and back
  • New or worsening constipation
  • Pain
  • Poor wound healing
  • Puffing cheeks
  • Redness in the arm or leg
  • Severe restlessness or need to keep moving
  • Shuffling walk
  • Skin rash
  • Stiffness of arms and legs
  • Swelling
  • Tenderness
  • Tiredness or weakness
  • Trembling and shaking of fingers and hands
  • Twisting movements
  • Unexplained weight loss
  • Warmth
  • Yellowing of skin or whites of eyes

Fluanxol (Flupenthixol) is available in the following forms and strength:

Fluanxol: Tablet

  • 0.5 mg
  • 3 mg

Before taking Fluanxol, tell your healthcare provider about your medical history, existing health conditions, and any medications you are taking.

Fluanxol is a prescription antipsychotic medication used to treat schizophrenia and, in certain countries, depression with or without anxiety.

Fluanxol works mainly by blocking dopamine receptors in the brain. Although this action helps control certain symptoms, it may also cause side effects involving movement, the nervous system, heart function, and hormone levels.

Some side effects may develop soon after starting treatment, while others may occur after prolonged use.

Your healthcare provider will determine whether Fluanxol is appropriate based on your condition, age, medical history, and response to treatment.

Tardive Dyskinesia

Fluanxol may cause tardive dyskinesia, a movement disorder involving repetitive, involuntary movements.

This condition is associated with long-term exposure to medications that block dopamine receptors, including typical antipsychotics such as flupentixol.

Tardive dyskinesia commonly affects the face, lips, tongue, and jaw. However, it may also involve the arms, legs, or other parts of the body.

Possible symptoms include:

  • Lip Smacking: Repeated movements of the lips that are difficult to control.
  • Tongue Movements: Unusual tongue movements or repeatedly sticking out the tongue.
  • Facial Grimacing: Repetitive facial expressions or muscle contractions.
  • Chewing Movements: Uncontrolled movements that resemble chewing.
  • Limb Movements: Repetitive movements of the arms, legs, fingers, or toes.

The risk of tardive dyskinesia may increase with higher doses and longer treatment periods, although it can also develop after shorter exposure.

In some people, symptoms may continue even after Fluanxol is discontinued.

Your healthcare provider may recommend regular assessments to identify early signs of abnormal movements.

Contact your healthcare provider promptly if you notice unusual movements of your face, tongue, or body.

Do not stop taking Fluanxol suddenly without medical advice. Your healthcare provider will determine whether reducing the dose, discontinuing treatment, or changing medications is appropriate. 

Extrapyramidal Symptoms and Movement Disorders

Fluanxol may cause extrapyramidal symptoms (EPS), which are movement-related side effects associated with dopamine receptor blockade.

Dopamine plays an important role in coordinating normal muscle movements.

When Fluanxol reduces dopamine activity in certain brain pathways, some people may develop muscle stiffness, tremors, restlessness, or involuntary movements.

These symptoms may occur during the early stages of treatment or after a dosage increase.

Common types of extrapyramidal symptoms include:

  • Dystonia: Sudden, involuntary muscle contractions that may cause painful spasms or unusual positions of the neck, jaw, eyes, or body.
  • Akathisia: A feeling of inner restlessness that makes it difficult to sit still. You may feel the need to pace, move your legs, or change positions frequently.
  • Drug-Induced Parkinsonism: Symptoms resembling Parkinson’s disease, including tremors, muscle stiffness, slowed movements, and difficulty maintaining balance.
  • Dyskinesia: Involuntary or repetitive movements affecting different parts of the body.

Your healthcare provider may recommend reducing your Fluanxol dosage or prescribing another medication to help manage certain movement-related side effects.

Some symptoms, such as acute dystonia or drug-induced parkinsonism, may respond to anticholinergic medications. However, these medications are not routinely recommended to prevent movement disorders and may worsen tardive dyskinesia.

Tell your healthcare provider if you experience persistent restlessness, muscle stiffness, tremors, or unusual movements.

Seek emergency medical attention if you develop severe muscle spasms that interfere with breathing or swallowing.

Liver Disease and Abnormal Liver Function

Tell your healthcare provider if you have liver disease or a history of abnormal liver function tests before taking Fluanxol.

The liver plays an important role in processing medications, including flupentixol.

If your liver is not functioning normally, the medication may be processed differently, potentially increasing the risk of unwanted effects.

Fluanxol may also cause changes in liver enzyme levels in some people.

Depending on the severity of your liver disease and the specific product information, treatment may be unsuitable or require additional monitoring.

Possible symptoms of liver problems include:

  • Yellowing of the Skin or Eyes: Also called jaundice.
  • Dark Urine: Urine may become unusually dark.
  • Persistent Nausea: Ongoing stomach discomfort or vomiting.
  • Abdominal Pain: Particularly pain in the upper right side of your abdomen.
  • Unusual Fatigue: Feeling significantly more tired or weak than normal.

Your healthcare provider may recommend liver function tests before or during treatment if you have liver disease or develop concerning symptoms.

Contact your healthcare provider promptly if you notice yellowing of your skin or eyes, dark urine, or persistent abdominal pain.

Low White Blood Cell Count

Fluanxol may rarely cause a decrease in the number of white blood cells in your body.

White blood cells help your immune system fight infections.

A low white blood cell count is called leukopenia. More severe reductions in certain white blood cells may result in neutropenia or agranulocytosis.

These conditions can make it harder for your body to fight bacterial and other infections.

Possible warning signs include:

  • Fever: An unexplained or persistent high temperature.
  • Sore Throat: Particularly when accompanied by fever or weakness.
  • Mouth Ulcers: Painful sores inside your mouth.
  • Frequent Infections: Developing infections more often than usual.
  • Unusual Weakness: Feeling significantly tired or unwell.

Tell your healthcare provider if you have previously experienced a low white blood cell count or medication-related blood disorders.

Your healthcare provider may recommend a complete blood count (CBC) when clinically appropriate, especially if you have a history of abnormal blood counts or develop signs of infection.

Contact your healthcare provider promptly if you develop an unexplained fever, persistent sore throat, or other symptoms suggesting infection. 

Low Blood Pressure and Orthostatic Hypotension

Fluanxol may cause a decrease in blood pressure, particularly when treatment begins or your dosage increases.

Some people may experience orthostatic hypotension, which occurs when blood pressure drops after standing up from a sitting or lying position.

This can temporarily reduce blood flow to the brain, causing dizziness or lightheadedness.

Possible symptoms include:

  • Dizziness: Feeling lightheaded when standing.
  • Blurred Vision: Temporary changes in vision.
  • Weakness: Feeling unsteady or unusually tired.
  • Fainting: Brief loss of consciousness caused by reduced blood pressure.
  • Loss of Balance: Difficulty standing or walking steadily.

To reduce dizziness, rise slowly from a sitting or lying position.

If you feel lightheaded, sit or lie down until the symptoms improve.

Your healthcare provider may recommend monitoring your blood pressure, particularly if you take medications for hypertension or have a history of falls.

Contact your healthcare provider if dizziness becomes frequent or interferes with your daily activities.

Seek urgent medical attention if you faint or experience a serious fall.

Epilepsy and Seizure Disorders

Fluanxol should be used with caution in people with a history of epilepsy or seizures.

Epilepsy is a neurological condition characterized by recurring seizures caused by abnormal electrical activity in the brain.

Some antipsychotic medications, including flupentixol, may lower the seizure threshold. This means seizures may become more likely in susceptible individuals.

Tell your healthcare provider if you have epilepsy, a history of convulsions, or another condition that increases your risk of seizures.

Your healthcare provider may review your seizure medications and determine whether additional monitoring is necessary.

Do not stop taking prescribed anticonvulsant medications without medical advice.

Contact your healthcare provider if you experience an increase in seizure frequency or unusual neurological symptoms.

Seek emergency medical attention if you experience a seizure lasting five minutes or longer, repeated seizures without recovery, or breathing difficulties during a seizure.

Sedation, Drowsiness, and Reduced Alertness

Fluanxol may cause drowsiness, fatigue, dizziness, or reduced alertness in some people.

These effects may be more noticeable when treatment begins or after your dosage increases.

Although Fluanxol can also cause restlessness or insomnia, some individuals experience sedation.

Sedation may affect your ability to concentrate, react quickly, or perform tasks requiring coordination.

Possible symptoms include:

  • Daytime Drowsiness: Feeling unusually sleepy during the day.
  • Reduced Concentration: Difficulty focusing on tasks.
  • Slower Reactions: Taking longer to respond to unexpected situations.
  • Dizziness: Feeling lightheaded or unsteady.
  • Fatigue: Persistent tiredness or reduced energy.

Avoid driving, operating heavy machinery, or performing potentially dangerous activities until you know how Fluanxol affects you.

Alcohol and other medications that cause drowsiness may increase these effects.

Tell your healthcare provider if sedation interferes with your daily routine or becomes difficult to manage.

Neuroleptic Malignant Syndrome

Fluanxol may rarely cause neuroleptic malignant syndrome (NMS), a serious and potentially life-threatening reaction associated with antipsychotic medications.

NMS affects the nervous system and can interfere with normal muscle function, body temperature regulation, and consciousness.

The condition can develop during treatment, particularly after starting an antipsychotic or increasing the dosage.

Symptoms may include:

  • High Fever: A sudden or unusually high body temperature.
  • Severe Muscle Stiffness: Significant muscle rigidity or difficulty moving.
  • Confusion: Changes in awareness, thinking, or behaviour.
  • Excessive Sweating: Heavy sweating unrelated to physical activity.
  • Rapid Heartbeat: An unusually fast or irregular heart rate.
  • Blood Pressure Changes: Blood pressure may become unusually high or low.
  • Reduced Consciousness: Severe drowsiness, confusion, or difficulty staying awake.

Neuroleptic malignant syndrome requires immediate medical treatment and may lead to serious complications if not recognized quickly.

Stop taking Fluanxol and seek emergency medical attention immediately if you develop a high fever with severe muscle stiffness, confusion, or changes in consciousness.

Do not take another dose until you have received medical guidance. 

Increased Prolactin Levels

Fluanxol may increase the level of prolactin, a hormone produced by the pituitary gland.

Prolactin plays an important role in breast development and milk production.

Dopamine normally helps control prolactin release. Because Fluanxol blocks dopamine receptors, it may reduce this control and cause prolactin levels to rise.

This condition is called hyperprolactinemia.

Possible symptoms include:

  • Breast Enlargement: Increased breast tissue in men or women.
  • Nipple Discharge: Milk production unrelated to pregnancy or breastfeeding.
  • Menstrual Changes: Irregular or absent menstrual periods.
  • Sexual Dysfunction: Reduced sexual interest or changes in sexual function.
  • Fertility Changes: Increased prolactin may interfere with normal reproductive hormone activity.

Not everyone taking Fluanxol will experience elevated prolactin levels or related symptoms.

However, persistent hyperprolactinemia may affect reproductive health and, in some cases, contribute to reduced bone density over time.

Tell your healthcare provider if you develop unusual breast changes, nipple discharge, missed menstrual periods, or sexual dysfunction.

Your healthcare provider may recommend checking prolactin levels or adjusting your treatment if necessary.

Cataracts and Other Eye Problems

Tell your healthcare provider if you have glaucoma, cataracts, or another existing eye condition before taking Fluanxol.

Some antipsychotic medications have been associated with visual disturbances and changes affecting the lens or other structures of the eye.

Rare cases of lens opacity have been reported with flupentixol. Related medications have also been associated with deposits affecting the lens or cornea.

Fluanxol may cause blurred vision or difficulty focusing, particularly during treatment.

Possible symptoms include:

  • Blurred Vision: Objects may appear less clear than usual.
  • Difficulty Focusing: Trouble adjusting your vision between near and distant objects.
  • Visual Changes: Unusual changes in eyesight.
  • Eye Discomfort: Persistent eye symptoms that require medical evaluation.

If you use Fluanxol for an extended period, your healthcare provider may recommend an eye examination based on your symptoms, medical history, and other risk factors.

Routine eye examinations are especially important if you already have a condition affecting your vision.

Contact your healthcare provider if you experience persistent blurred vision or other changes in eyesight.

Seek urgent medical attention if you develop sudden vision loss or severe eye pain. 

Increased Risk of Falls in Older Adults

Older adults may be more sensitive to certain side effects of Fluanxol, including dizziness, sedation, muscle stiffness, and changes in blood pressure.

These effects can increase the risk of falls and injuries.

Fluanxol may cause orthostatic hypotension, which can make you feel dizzy when standing up.

Movement-related side effects, such as tremors, stiffness, or slowed movements, may also affect balance and coordination.

Older adults may have additional risk factors, including reduced mobility, vision problems, and the use of multiple medications.

Your healthcare provider may recommend a lower starting dose and careful dosage adjustments.

If you experience dizziness, move slowly when standing and use appropriate support when walking.

Tell your healthcare provider about any falls, balance problems, or changes in mobility.

Fluanxol is not approved to treat dementia-related psychosis in older adults. Antipsychotics are associated with an increased risk of death in this population.

QT Prolongation and Heart Rhythm Problems

Fluanxol may affect the electrical signals that control your heartbeat.

In some individuals, the medication can prolong the QT interval, which measures how long the heart takes to recover electrically between beats.

A prolonged QT interval may increase the risk of serious abnormal heart rhythms.

Tell your healthcare provider if you have a history of heart disease, irregular heartbeat, heart failure, or unexplained fainting.

Additional risk factors include low potassium or magnesium levels and the use of other medications that prolong the QT interval.

Possible symptoms of an abnormal heart rhythm include:

  • Heart Palpitations: Feeling that your heart is racing, pounding, or skipping beats.
  • Dizziness: Sudden lightheadedness or weakness.
  • Fainting: Temporary loss of consciousness.
  • Chest Discomfort: Unusual chest pressure or pain.
  • Shortness of Breath: Difficulty breathing without an obvious cause.

Your healthcare provider may recommend an electrocardiogram (ECG) to assess your heart rhythm if you have relevant risk factors.

You may also need blood tests to check potassium and magnesium levels.

Seek emergency medical attention if you experience fainting, chest pain, or a persistent irregular heartbeat. 

Drug Interactions

Fluanxol may interact with medications that affect the central nervous system, heart rhythm, blood pressure, or dopamine activity.

Some interactions may increase side effects, while others may reduce the effectiveness of treatment.

Medications that may require additional precautions include:

  • Other Antipsychotics: Combining antipsychotic medications may increase the risk of movement disorders, sedation, and heart rhythm problems.
  • Sedatives and Sleeping Medications: Benzodiazepines, sleeping pills, and other sedating medicines may increase drowsiness and reduce alertness.
  • Opioid Pain Medications: Opioids may increase sedation and other central nervous system effects.
  • Blood Pressure Medications: Certain antihypertensive medications may increase the risk of low blood pressure and dizziness.
  • Heart Rhythm Medications: Medications that prolong the QT interval may increase the risk of serious arrhythmias.
  • Levodopa and Other Dopamine-Related Medications: Fluanxol may reduce the effectiveness of some medications used to treat Parkinson’s disease.
  • Lithium: Combining lithium with antipsychotics may increase the risk of certain neurological reactions and requires careful monitoring.
  • Anticholinergic Medications: These may affect movement-related side effects but can also increase dry mouth, constipation, and other unwanted reactions.

Alcohol may increase sedation, dizziness, and impaired coordination while taking Fluanxol.

Tell your healthcare provider or pharmacist about all prescription medications, over-the-counter drugs, vitamins, and herbal supplements you use.

Do not start, stop, or change another medication without consulting your healthcare provider.

When to Contact Your Healthcare Provider

Contact your healthcare provider if you experience persistent dizziness, unusual muscle movements, restlessness, tremors, changes in vision, menstrual irregularities, or excessive drowsiness while taking Fluanxol.

You should also report new signs of infection, such as unexplained fever, sore throat, or unusual weakness.

Seek urgent medical advice if you develop involuntary facial or tongue movements, significant muscle stiffness, or new neurological symptoms.

Seek emergency medical attention immediately if you experience a high fever with severe muscle rigidity, confusion, difficulty breathing, fainting, or a serious irregular heartbeat.

Do not stop Fluanxol suddenly unless you are experiencing a serious reaction requiring immediate discontinuation and emergency care. Abrupt withdrawal can cause nausea, vomiting, sweating, insomnia, and a return of the symptoms being treated.

Fluanxol can help manage certain symptoms of schizophrenia and other approved conditions, but it requires careful monitoring for movement disorders, neurological reactions, and cardiovascular effects. Taking the prescribed dose, attending regular medical appointments, and reporting unusual symptoms promptly can help reduce treatment-related risks.

How Long Does It Take for Fluanxol to Work?

Fluanxol may take several days or weeks to produce noticeable improvements in symptoms. The time needed for the medication to work depends on the condition being treated, the prescribed dosage, and your individual response. Fluanxol belongs to a class of medications called typical antipsychotics. It works mainly by blocking dopamine receptors in the brain, helping regulate dopamine activity and control certain symptoms associated with schizophrenia. Some people may notice improvements in their symptoms within the first few days of treatment. However, the full antipsychotic effects may take several weeks to develop. For people with schizophrenia, symptoms such as hallucinations, delusions, and disorganized thinking may gradually improve as treatment continues. When low-dose Fluanxol is prescribed for depression with or without anxiety, improvements in mood and emotional symptoms may occur over a different period. Your healthcare provider will monitor your response to treatment and determine whether dosage adjustments are necessary. Continue taking Fluanxol exactly as prescribed, even if you do not notice immediate improvement. Do not increase your dosage or stop treatment without consulting your healthcare provider. If your symptoms become worse or do not improve within the expected treatment period, contact your healthcare provider.

Can Fluanxol Be Used for Anxiety?

Fluanxol is not generally considered a first-line treatment for anxiety disorders. However, low-dose Fluanxol tablets may be prescribed for depression accompanied by anxiety in certain countries. Fluanxol contains flupentixol, a typical antipsychotic medication that mainly affects dopamine activity in the brain. At higher doses, Fluanxol is primarily used to manage symptoms of schizophrenia and other approved psychotic conditions. At lower doses, it may help relieve certain depressive symptoms, including nervousness, tension, and anxiety associated with depression. For example, in the United Kingdom, low-dose Fluanxol tablets are approved for the treatment of depression with or without anxiety. However, Fluanxol is not routinely prescribed to treat anxiety alone, and its approved uses vary depending on the country and formulation. Other treatments, including cognitive behavioral therapy and certain antidepressant medications, are generally preferred for common anxiety disorders. Your healthcare provider will determine whether Fluanxol is appropriate based on your symptoms, medical history, and response to previous treatments. Do not take Fluanxol for anxiety unless it has been specifically prescribed for you.

Is Fluanxol Addictive?

No, Fluanxol is not generally considered an addictive medication. Fluanxol contains flupentixol, an antipsychotic medication that works by changing dopamine activity in the brain. Unlike medications associated with addiction, Fluanxol does not typically cause drug cravings, compulsive drug-seeking behavior, or feelings of euphoria. However, your body may adjust to Fluanxol during regular treatment. Suddenly stopping the medication may cause withdrawal symptoms, including nausea, vomiting, diarrhea, difficulty sleeping, restlessness, increased sweating, and loss of appetite. Some people may also experience unusual agitation or discomfort after discontinuing treatment. Stopping Fluanxol abruptly may also cause the symptoms being treated to return or become worse. For example, people taking Fluanxol for schizophrenia may experience a return of hallucinations, delusions, or other psychotic symptoms. Experiencing withdrawal symptoms does not mean you are addicted to Fluanxol. These symptoms may occur because your body has adapted to the medication and needs time to adjust when treatment is reduced or stopped. If you need to discontinue Fluanxol, your healthcare provider may recommend gradually lowering your dosage over time. This process, called dose tapering, allows your body to adjust to lower medication levels and may help reduce withdrawal symptoms and the risk of symptom recurrence. Do not stop taking Fluanxol suddenly without consulting your healthcare provider. Your healthcare provider can recommend a safe discontinuation plan based on your current dosage, treatment duration, medical history, and individual response to the medication.

Can Fluanxol Be Used in Children?

Fluanxol is generally not recommended for children and adolescents because its safety and effectiveness have not been adequately established in pediatric patients. Fluanxol contains flupentixol, a typical antipsychotic medication that affects dopamine activity in the brain. Although antipsychotic medications are sometimes used to treat certain conditions in younger patients, not every medication is approved or appropriate for children. Fluanxol may cause side effects involving movement, hormone levels, the nervous system, and heart rhythm. Possible side effects include muscle stiffness, tremors, restlessness, involuntary movements, dizziness, and changes in prolactin levels. These effects require careful consideration in children and adolescents who are still growing and developing. The prescribing information for Fluanxol generally does not establish routine pediatric dosages, and certain formulations are not recommended for patients younger than 18 years. If your child has a condition that may require antipsychotic treatment, a qualified healthcare provider should assess their symptoms and recommend an age-appropriate medication. Do not give Fluanxol to a child unless a specialist has specifically prescribed it and established an appropriate monitoring plan.

What Should I Do If I Miss a Dose of Fluanxol?

If you forget to take a dose of Fluanxol tablets, take it as soon as you remember, unless it is almost time for your next scheduled dose. If your next dose is approaching, skip the missed dose and continue with your regular treatment schedule. Do not take two doses at the same time or take extra tablets to make up for a missed dose. Taking more Fluanxol than prescribed may increase your risk of side effects, including dizziness, excessive drowsiness, low blood pressure, muscle stiffness, and abnormal movements. To help prevent missed doses, try taking Fluanxol at approximately the same time each day. You may find it helpful to use a medication reminder, daily schedule, or pill organizer. If you frequently forget your medication, speak with your healthcare provider or pharmacist about ways to manage your treatment more consistently. If you miss several doses, contact your healthcare provider before restarting, as your treatment schedule may need to be reviewed. For patients receiving Fluanxol Depot injections, missed-dose instructions are different because the medication is administered by a healthcare professional at scheduled intervals. If you miss an injection appointment, contact your healthcare provider promptly to arrange the next dose. Always follow your prescribed Fluanxol treatment schedule. Taking your medication consistently helps maintain symptom control and reduces the risk of problems associated with missed doses or sudden treatment interruption.

REVIEWS

Additional Information Book
Generic name:

Flupenthixol

Formulation:

Tablet

Strength(s):

0.5mg, 3mg

Quantities Available:

100

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Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Fluanxol can I order at once from a Canadian pharmacy?

When ordering Fluanxol (flupenthixol) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Fluanxol is commonly prescribed in dosages of 0.5 mg or 3 mg, taken once to three times daily. For a 90-day supply, this means you would order up to 270 tablets (90 days x 3 tablets per day) depending on your prescribed dosage.

Do you sell flupenthixol?

No, we do not sell flupenthixol directly on our website. However, you can still enjoy low prices on Fluanxol, which contains flupenthixol as an active ingredient. To purchase Fluanxol, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Fluanxol (flupenthixol) to the United States?

Yes, we ship Fluanxol (flupenthixol) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Fluanxol (Flupenthixol). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Fluanxol (Flupenthixol).