Xerese (Acyclovir/Hydrocortisone)

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Xerese Brand
Dosage Quantity & Price
Acyclovir/Hydrocortisone (Generic alternate to Xerese) Generic

We don't sell this generic-version medication.

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Table of contents:

Xerese is a topical cream medication indicated for early treatment of recurrent herpes labialis to reduce the likelihood of lesion development and shorten the healing time. It can be used to treat cold sores (herpes labialis). Xerese contains acyclovir and hydrocortisone.

Acyclovir is an antiviral medication that works by stopping the growth of the virus causing the cold sore. Hydrocortisone is a corticosteroid that helps relieve itching, pain, and swelling. Together, the two medications in Xerese are used to treat cold sores and to lessen the healing time of cold sores caused by the herpes simplex virus.

Use and Dosage

Xerese cream is a prescription medication used to treat cold sores (herpes labialis) on and around the mouth. Here are some tips for using Xerese:

  1. Use Xerese cream at the first sign of a cold sore outbreak.
  2. Before applying the cream, wash your hands with soap and water to prevent the spread of infection.
  3. Clean and dry the affected area before applying the cream.
  4. Apply a thin layer of Xerese cream over the affected area as directed by your healthcare provider. This is usually done 5 times a day (every 3 to 4 hours) for 5 days.
  5. Make sure to apply enough cream to cover all affected areas, but avoid rubbing the cream into your skin, as this can make the cold sore worse or spread the virus to other areas around your mouth.
  6. Do not apply other skin products like make-up, sunscreen, or lip balm to the affected area, and do not cover the area with a bandage.
  7. To prevent washing off the medication, wait at least 30 minutes after applying the Xerese cream before bathing, showering, or swimming.

Xerese cream should not be applied in the eyes, nose, mouth, or genitals. It is also not a cure for herpes and will not prevent the spread of the virus to other people. Therefore, you should avoid kissing or sharing eating utensils, cups, razors, or towels during an outbreak. If you do touch the cold sore, make sure to wash your hands afterward.

Use Xerese cream regularly as directed by your healthcare provider to get the most benefit from it. If your condition lasts or worsens after 2 weeks, be sure to inform your healthcare provider.

Side Effects

Common Side Effects of Xerese (Acyclovir/Hydrocortisone):

  • Bitter taste in your mouth after applying for the medicine
  • Burning or tingling following application
  • Changes in skin color
  • Drying or flaking of the skin
  • Inflammation at the application site
  • Skin redness

Serious Side Effects of Xerese (Acyclovir/Hydrocortisone):

  • Hives
  • Difficulty breathing
  • Swelling of your face, lips, tongue, or throat
  • Burning, stinging, or irritation of treated skin
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

Forms and Strength

Xerese (Acyclovir/Hydrocortisone) is available in the following forms and strength:

Xerese: Cream

  • 5/1%


  • Xerese is intended for cutaneous use only for herpes labialis of the lips and around the mouth.
  • Xerese should not be used in individuals who are allergic to acyclovir or hydrocortisone.
  • Before using Xerese, you should inform your healthcare provider if you have any medical conditions or are taking any medications, including over-the-counter drugs and herbal remedies.
  • Xerese may cause serious side effects including hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.
  • Xerese should be used with caution in individuals with immune system problems, as they may be more susceptible to the side effects of the medication.
  • Xerese is not recommended for use during pregnancy or while breastfeeding.
  • Xerese should not be used in individuals with chickenpox or shingles, as it may make the condition worse.
  • Xerese should be applied to the affected area only. It should not be applied near the eyes, inside the nose or mouth, or on the genitals.
  • Xerese should be used for the full course of treatment as prescribed by your healthcare provider, even if symptoms improve before the end of treatment.
  • Xerese may interact with other medications, including prescription and over-the-counter drugs, supplements, and herbal remedies.
  • Xerese may increase the risk of developing a bacterial infection or a fungal infection.
  • Xerese may increase your risk of sunburn. You should avoid prolonged sun exposure and wear protective clothing and sunscreen while using Xerese.
  • Xerese may cause hormonal changes in some individuals. It should be used with caution in individuals with diabetes, hypertension, or other endocrine disorders.

Frequently Asked Questions (FAQ)

How long should I use Xerese?

Xerese should be used for the full course of treatment as prescribed by your healthcare provider, even if symptoms improve before the end of treatment.

Can Xerese be used to prevent cold sores?

No, Xerese is not recommended for the prevention of cold sores. It should only be used to treat an active outbreak.

Can Xerese be used in children?

Xerese has not been studied extensively in children, and its safety and effectiveness in pediatric patients have not been established.

Can Xerese be used for other skin conditions?

No, Xerese is specifically indicated for the treatment of cold sores caused by herpes simplex virus.


It's important to purchase Xerese from verified Canadian pharmacy.

Additional information

Generic name:






Quantities Available:

5g, 10g, 15g