Crixivan (Indinavir)

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Crixivan Brand

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Indinavir (Generic alternate to Crixivan) Generic
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Crixivan is a prescription medicine used to treat the symptoms of HIV Infection. Crixivan's active ingredient is indinavir, which is a medication that belongs to a class of drugs called protease inhibitors. Protease is an enzyme required for the replication and spread of the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS). Indinavir works by blocking the action of the protease enzyme, which then prevents the virus from multiplying and lowers the amount of HIV in the blood.

When taken in combination with other antiretroviral drugs known as nucleoside analogues, Crixivan (indinavir) can help to slow the progression of HIV infection and reduce the risk of developing HIV-related illnesses. However, note that Crixivan is not a cure for HIV infection and does not prevent the transmission of HIV to others.

Use and Dosage

Indinavir is typically prescribed as a capsule to take by mouth every 8 hours, or three times a day. Do not crush or chew the capsule, but it may be opened and mixed with fruit puree (such as banana). Take indinavir at around the same time every day and follow the prescription label directions carefully. Be sure to discuss this with your doctor or pharmacist if you have any questions or concerns.

Indinavir should be taken on an empty stomach, typically 1 hour before meals or 2 hours after meals, with water, skim or nonfat milk, juice, coffee, or tea. If indinavir upsets your stomach, you may take it with a light meal such as dry toast or cornflakes with skim or nonfat milk. Tell your doctor or pharmacist to determine which foods may be taken with indinavir.

Continue taking indinavir even if you feel well, and not stop taking it without consulting your doctor. If you experience certain side effects, your doctor may need to interrupt your treatment, so be sure to keep your doctor informed about how you are feeling during your treatment with indinavir.

Side Effects

Common Side Effects of Crixivan (Indinavir):

  • Altered sense of taste
  • Back pain
  • Changes in appetite
  • Changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist)
  • Diarrhea
  • Dizziness
  • Dry skin
  • Headache
  • Heartburn
  • Indigestion
  • Itching
  • Nausea
  • Rash
  • Sneezing
  • Sore throat
  • Stomach pain
  • Stuffy nose
  • Tiredness
  • Vomiting
  • Weakness

Serious Side Effects of Crixivan (Indinavir):

  • Anxiety
  • Blood in your urine
  • Blurred vision
  • Chest pain
  • Clay-colored stool
  • Cold sores
  • Confusion
  • Dark colored urine
  • Difficulty breathing
  • Drowsiness
  • Dry cough
  • Dry mouth
  • Dry skin
  • Fever
  • Fruity breath odor
  • Hives
  • Hunger
  • Impotence and
  • Increased thirst
  • Increased urination
  • Irritableness
  • Itching
  • Loss of appetite
  • Loss of bladder or bowel control
  • Loss of interest in sex
  • Menstrual changes
  • Mouth sores
  • Night sweats
  • Pain in your side or lower back
  • Painful or difficult urination
  • Pale or yellowed skin
  • Problems or eye movement
  • Rapid heart rate
  • Severe lower back pain
  • Shortness of breath
  • Sores on your genital or anal area
  • Stomach pain
  • Swelling in your neck or throat (enlarged thyroid)
  • Swelling of your face lips tongue or throat
  • Swollen glands
  • Tenderness
  • Tired feeling
  • Trouble speaking or swallowing
  • Unexplained muscle pain
  • Unusual tiredness
  • Upper stomach pain
  • Weakness or prickly feeling
  • Weakness with fever
  • Weight loss
  • Wheezing
  • Yellowing of the skin or eyes (jaundice)

Forms and Strength

Crixivan (Indinavir) is available in the following forms and strength:

Indinavir: Capsule

  • 400 mg


  • Indinavir can interact with other drugs and cause potentially serious side effects.
  • Indinavir may cause elevated liver enzyme levels and liver toxicity.
  • Crixivan can cause kidney stones and kidney problems, particularly in patients with a history of kidney disease.
  • Indinavir may interact with certain antidepressants, increasing the risk of side effects such as serotonin syndrome.
  • Indinavir can cause skin reactions, including a rash and Stevens-Johnson syndrome, a severe and potentially life-threatening skin disorder.
  • Indinavir may cause gastrointestinal side effects such as nausea, diarrhea, and vomiting.
  • The medication may increase the risk of bleeding in patients with hemophilia.
  • Patients with diabetes may experience changes in their blood sugar levels while taking Crixivan. Discuss these potential risks with a healthcare provider before taking Crixivan.
  • Patients with a history of hemophilia or those on anticoagulant therapy may be at an increased risk of bleeding when taking Crixivan.
  • The medication may increase the risk of cardiovascular disease, particularly in patients with other risk factors such as smoking or a history of heart disease.
  • Indinavir should be used with caution in patients with a history of pancreatitis or those with elevated triglyceride levels.
  • Indinavir may interact with herbal supplements, particularly St. John's Wort, which can reduce the effectiveness of Crixivan.

Frequently Asked Questions (FAQ)

Can I take Indinavir during pregnancy?

Indinavir is not recommended for use during pregnancy, as it may increase the risk of side effects in both the mother and the developing baby. If you are pregnant, talk to your doctor about alternative treatment options.

What should I avoid while taking Indinavir?

Avoid taking certain medications that can interact with Indinavir, including certain antibiotics, antifungal medications, and other HIV medications. You should also avoid drinking alcohol while taking Crixivan.

Can I breastfeed while taking Indinavir?

It is not known if Indinavir is excreted in human breast milk, women avoid breastfeeding while taking this medication.

How long does it take for Indinavir to start working?

Indinavir can start to reduce the amount of HIV in the body within 2-4 weeks of starting treatment. However, continue taking the medication as directed by your doctor, even if you start to feel better.


It's important to purchase Crixivan from verified Canadian pharmacy.

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