Valdoxan (Agomelatine)

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Valdoxan Brand
Dosage Quantity & Price
25mg
Agomelatine (Generic alternate to Valdoxan) Generic

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Table of contents:

Valdoxan is a prescription medication used in the treatment of depression and the prevention of relapse of depressive episodes. It can be indicated to treat adults with major depressive disorder, a condition in which patients have persistent feelings of sadness, worthlessness, and hopelessness that interfere with their daily life.

Valdoxan contains the active ingredient Agomelatine and is available as a film-coated tablet. Unlike most other antidepressants, it works by acting on both melatonin and serotonin receptors in the brain, rather than just the serotonin receptors.

Use and Dosage

Valdoxan (Agomelatine) comes in the form of a film-coated tablet and is taken orally. It may be taken with or without food, as advised by a doctor. Follow your doctor's instructions regarding the use and dosage of Valdoxan. Treatment should not be started or should be stopped in patients with abnormal liver enzyme levels in the blood (more than three times the normal level).

The recommended dose is one tablet once a day, taken at bedtime. The usual recommended dose is one tablet of 25mg taken orally once daily, at bedtime. It may be taken with or without food. If there is no improvement in symptoms after two weeks, the doctor may increase the dose to two tablets taken together at bedtime. Patients with depression should be treated for at least six months to ensure they are free of symptoms.

Follow the instructions of your doctor regarding the use of Valdoxan, and to not take more or less of it than prescribed. Also, do not stop taking the medication abruptly without discussing it with your doctor first, as this may cause withdrawal symptoms.

Side Effects

Common Side Effects of Valdoxan (Agomelatine):

  • Abnormal dreams
  • Difficulty in sleeping (insomnia)
  • Dizziness
  • Headache
  • Inability to remain still
  • Migraine
  • Pins and needles in the fingers and toes
  • Restless legs syndrome
  • Sleepiness

Serious Side Effects of Valdoxan (Agomelatine):

  • Abnormal bleeding or bruising
  • Aggressive behavior
  • Agitation
  • Anxiety
  • Confusion
  • Hallucinations
  • Irritability
  • Itching, skin rash or hives
  • Nightmares
  • Restlessness
  • Shortness of breath, wheezing or trouble breathing
  • Suicidal thoughts or behaviour
  • Swelling of the face, lips, tongue, or other parts of the body
  • Yellow coloring of the skin or whites of the eyes (jaundice)

Forms and Strength

Valdoxan (Agomelatine) is available in the following forms and strength:

Valdoxan: Tablets

  • 25 mcg

Cautions

  • Caution is advised when prescribing agomelatine to patients with liver disease or a history of liver disease, as the medication is metabolized in the liver.
  • Agomelatine should not be used in patients with severe kidney disease or end-stage renal failure, as there is limited information on the safety and effectiveness of the medication in this patient population.
  • There have been rare reports of hepatitis and elevated liver enzymes in patients taking agomelatine, so liver function tests should be performed before starting the medication and periodically during treatment.
  • Agomelatine should not be used in patients who are taking certain medications that can increase the risk of liver damage, such as ketoconazole or rifampicin.
  • Agomelatine can cause dizziness and somnolence, which can impair a patient's ability to drive or operate machinery. Patients should be advised to avoid these activities until they know how the medication affects them.
  • There may be an increased risk of suicidal thoughts or behavior in some patients taking antidepressant medications, including agomelatine. Patients should be closely monitored, particularly when starting the medication or changing the dose.
  • Agomelatine should not be used in pregnancy unless the potential benefits outweigh the risks. The medication is excreted in breast milk, so caution should be exercised when prescribing it to nursing mothers.
  • Agomelatine should not be used in patients with a history of mania or hypomania, as it may induce these conditions in vulnerable patients.
  • Patients taking agomelatine should be advised to avoid alcohol, as it can increase the risk of side effects such as dizziness and sedation.
  • Agomelatine should be used with caution in patients with a history of epilepsy or seizures, as it may lower the seizure threshold.
  • There is limited information on the safety and effectiveness of agomelatine in elderly patients, so caution should be exercised when prescribing the medication to this population.
  • Agomelatine should be used with caution in patients with a history of bleeding disorders or those taking anticoagulant medications, as it may increase the risk of bleeding.
  • Patients taking agomelatine should be monitored for signs of serotonin syndrome, a potentially life-threatening condition that can occur when there is an excess of serotonin in the brain.
  • Agomelatine may interact with certain medications, so patients should inform their healthcare provider of all medications they are taking before starting the medication.

Frequently Asked Questions (FAQ)

Can Valdoxan be used during pregnancy?

Valdoxan should be used with caution during pregnancy, and only if the potential benefits outweigh the risks to the fetus. Discuss any potential risks with a healthcare provider before taking the medication.

Is Valdoxan addictive?

Valdoxan is not believed to be addictive and does not have potential for abuse. However, as with all prescription medication, patients should follow their healthcare provider's instructions on use and dosing.

Can Valdoxan be used with other medications?

Valdoxan may interact with certain medications, so patients should inform their healthcare provider of all medications they are taking before starting the medication. It should not be used in combination with medications that may increase the risk of liver damage.

Resources

It's important to purchase Valdoxan from verified Canadian pharmacy.

Additional information

Generic name:

Agomelatine

Formulation:

Tablet

Strength(s):

25mg

Quantities Available:

28

REVIEWS

Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Valdoxan (Agomelatine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Valdoxan (Agomelatine).