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Twynsta is a prescription medication used to treat high blood pressure, also known as hypertension. It is a combination drug that contains two active ingredients: telmisartan, which belongs to a class of drugs called angiotensin receptor blockers (ARBs), and amlodipine, which belongs to a class of drugs called calcium channel blockers.

Twynsta works by blocking receptors in the body that cause blood vessels to narrow and by relaxing the blood vessels to help improve blood flow and lower blood pressure. Twynsta is typically prescribed for adults who need multiple medications to help control their blood pressure.

Use and Dosage

Twynsta comes in the form of tablet to take orally with or without food, as directed by a doctor, typically once per day. The specific dosage of this medication is determined by your medical condition and your individual response to treatment.

The recommended dosage of Twynsta varies depending on the individual's needs and can be as low as 40/5 mg once daily and as high as 80/10 mg once daily. However, the maximum recommended dose of Twynsta is 80/10 mg once daily. The dosage should be individualized and subject to the prescribing doctor's recommendation. Consult with a healthcare professional before starting or changing any medication.

To ensure you receive maximum benefits from Twynsta, take the tablet regularly at the same time each day. Even if you are feeling well, continue taking the medication since most people with high blood pressure do not experience any symptoms. In some cases, it may take at least four weeks to notice the full benefits of using Twynsta. If your condition fails to improve or even worsens, such as blood pressure readings that remain high or increase, inform your doctor as soon as possible.

Side Effects

Common Side Effects of Twynsta (Amlodipine/Telmisartan):

  • Back pain
  • Diarrhea
  • Dizziness or lightheadedness as your body adjusts to the medication
  • Drowsiness
  • Fast or pounding heartbeats
  • Flushing (warmth, redness, or tingly feeling)
  • Nausea
  • Swelling in your hands or feet
  • Tired feeling
  • Vomiting

Serious Side Effects of Twynsta (Amlodipine/Telmisartan):

  • Fainting
  • Fast/pounding/irregular heartbeat
  • Fluttering in your chest
  • Lightheadedness
  • Loss of movement
  • Muscle stiffness
  • Nausea
  • New or worsening chest pain
  • Pounding heartbeats
  • Rapid weight gain
  • Shortness of breath
  • Slow or unusual heart rate
  • Swelling
  • Symptoms of high potassium levels in the blood (such as muscle weakness, slow/irregular heartbeat)
  • Tremors
  • Twitching
  • Unusual changes in the amount of urine
  • Weakness

Forms and Strength

Twynsta (Amlodipine/Telmisartan) is available in the following forms and strength:

Twynsta: Tablet

  • 5/40 mg
  • 5/80 mg
  • 10/40 mg
  • 10/80 mg

Amlodipine/Telmisartan: Tablet

  • 5/40 mg
  • 5/80 mg


  • Fetal toxicity: Twynsta has been associated with fetal toxicity, so it should not be used during pregnancy. Women who are pregnant or planning to become pregnant should talk to their doctor about alternative treatments.
  • Renal impairment: There is limited experience with the use of Twynsta in patients with severe renal impairment or those undergoing hemodialysis, so caution is advised.
  • Hepatic impairment: Twynsta should be used with caution in patients with hepatic impairment because it is metabolized by the liver.
  • Hypotension: Twynsta can cause symptomatic hypotension, particularly in patients with severe volume depletion or intravascular fluid volume depletion. The risk of hypotension may be higher in patients with severe hypertension.
  • Hyperkalemia: Twynsta can cause hyperkalemia (elevated levels of potassium in the blood) in some patients, particularly those with renal impairment or diabetes, or those taking other medications that increase potassium levels. Serum potassium levels should be monitored regularly in such patients.
  • Concomitant use with other antihypertensives: Twynsta should be used with caution in patients taking other antihypertensive medications, as concomitant use can increase the risk of hypotension.
  • Angioedema: Twynsta may cause angioedema (swelling of the face, lips, tongue, or throat), which can be life-threatening. Patients who develop angioedema should stop taking Twynsta and seek immediate medical attention.
  • Hypertension: Twynsta may not be appropriate for all patients with hypertension, particularly those with severe hypertension or underlying conditions such as kidney disease.
  • Use in elderly patients: Twynsta should be used with caution in elderly patients, who may be more sensitive to the effects of the medication.
  • Potential drug interactions: Twynsta may interact with other medications, including diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), lithium, and certain other blood pressure medications. Patients should inform their doctor of all medications they are taking before starting treatment with Twynsta.

Frequently Asked Questions (FAQ)

Can Twynsta be taken during pregnancy or while breastfeeding?

Twynsta should not be taken during pregnancy or while breastfeeding, as it can harm an unborn or nursing baby. Talk to your doctor if you are pregnant or planning to become pregnant, or if you are breastfeeding.

What should I do if I miss a dose of Twynsta?

If you miss a dose of Twynsta, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not double the dose to catch up.

Can Twynsta cause allergic reactions?

Yes, Twynsta can cause allergic reactions in some people. Signs of an allergic reaction may include rash, itching, swelling, or difficulty breathing. If you experience any of these symptoms, seek medical attention immediately.

How long does it take for Twynsta to start working?

Twynsta can start working within a few hours of taking the first dose, but it may take several weeks to achieve the full blood pressure-lowering effects. Continue taking the medication as prescribed, even if you feel well.


Additional information

Generic name:





5/40mg, 5/80mg, 10/40mg, 10/80mg

Quantities Available:

84, 90


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Twynsta (Amlodipine/Telmisartan). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Twynsta (Amlodipine/Telmisartan).