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Avalide contains two active ingredients: irbesartan and hydrochlorothiazide. It is a prescription medication used to lower high blood pressure when treatment with one medication alone does not provide enough control.
Avalide is used to treat hypertension, also called high blood pressure.
Blood pressure is the force of blood pushing against the walls of the arteries. When this pressure remains too high, the heart must work harder to pump blood throughout the body.
High blood pressure often does not cause noticeable symptoms. However, if it is not controlled, it can gradually damage the blood vessels, heart, kidneys, brain, and other organs.
Over time, uncontrolled high blood pressure may increase the risk of:
Avalide may be prescribed when irbesartan, hydrochlorothiazide, or another blood pressure medication does not lower blood pressure enough when used alone.
It may also be prescribed as an initial treatment when a healthcare provider believes that a patient is likely to need more than one medication to reach their blood pressure goal.
Avalide helps control high blood pressure, but it does not cure it. Continue taking the medication as prescribed, even if you feel well.
Avalide combines two medications that lower blood pressure in different ways.
Irbesartan
Irbesartan belongs to a group of medications called angiotensin II receptor blockers, also known as ARBs.
Angiotensin II is a natural substance in the body that causes blood vessels to tighten and narrow. It can also encourage the body to retain sodium and water.
Irbesartan blocks angiotensin II from attaching to its receptors. This allows the blood vessels to relax and widen.
As a result:
Hydrochlorothiazide
Hydrochlorothiazide is a thiazide diuretic, commonly called a water pill.
It works in the kidneys by increasing the removal of sodium and water from the body through urine. Reducing excess fluid lowers the amount of blood circulating through the blood vessels.
This helps:
Hydrochlorothiazide may also affect certain electrolytes in the blood, including potassium and sodium. A healthcare provider may order blood tests during treatment to monitor these levels.
Combined Effect
Irbesartan and hydrochlorothiazide work together to provide stronger blood pressure control than either medication may provide alone.
Irbesartan relaxes the blood vessels, while hydrochlorothiazide helps remove excess sodium and water from the body. These combined effects reduce pressure inside the arteries and make it easier for the heart to circulate blood.
Avalide may take several weeks to provide its full blood pressure-lowering benefit. Regular blood pressure checks help the healthcare provider determine how well the medication is working and whether the dose needs to be adjusted.
Avalide is available as an oral tablet containing irbesartan and hydrochlorothiazide. Take it exactly as prescribed by your healthcare provider, usually once daily.
You may take Avalide with or without food. Swallow the tablet with water and try to take it at approximately the same time each day. A consistent schedule can help you remember your dose and maintain steady blood pressure control.
Do not take more tablets, use the medication more often, or change your dose without speaking with your healthcare provider.
Hydrochlorothiazide is a diuretic, sometimes called a water pill. It may cause you to urinate more often, especially during the first few hours after taking a dose.
Taking Avalide in the morning may help reduce the need to urinate during the night. When a morning dose is not possible, try to take it at least four hours before bedtime unless your healthcare provider gives you different instructions.
For patients whose blood pressure is not adequately controlled with irbesartan or hydrochlorothiazide alone, the available dosing options include:
The appropriate starting dose depends on the medication and dose you were taking before switching to Avalide. The dose should be individualized rather than automatically started at the same strength for every patient.
Your healthcare provider may check your blood pressure and adjust the dose based on your response to treatment.
The full blood pressure-lowering effect of a dose may take approximately two to four weeks to develop. Your healthcare provider may wait during this period before deciding whether you need a higher dose.
The maximum recommended dose is 300 mg of irbesartan with 25 mg of hydrochlorothiazide once daily.
Do not increase the dose on your own, even if your blood pressure remains high. Taking too much may cause very low blood pressure, dizziness, fainting, dehydration, kidney problems, or changes in electrolyte levels.
Certain cholesterol-lowering medicines, known as bile acid–binding resins, can reduce the absorption of hydrochlorothiazide.
Examples include:
Take Avalide at least four hours before or four to six hours after these medicines. This spacing helps prevent the cholesterol medicine from reducing the amount of hydrochlorothiazide absorbed by your body.
Take Avalide every day, even if you feel well. High blood pressure often does not cause symptoms, so you may not feel a noticeable difference while the medication is working.
Avalide controls high blood pressure but does not cure it. Stopping treatment may cause your blood pressure to rise again and increase the risk of heart, brain, kidney, or blood vessel complications.
Do not stop taking Avalide unless your healthcare provider tells you to do so.
Your healthcare provider may check your blood pressure and order blood tests before and during treatment.
These tests may be used to monitor:
Monitoring is especially important after treatment begins, after the dose is increased, or if you develop vomiting, diarrhea, excessive sweating, or reduced fluid intake.
Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your normal schedule.
Do not take two doses at the same time to make up for a missed dose.
Taking too much Avalide may cause severe dizziness, weakness, fainting, dehydration, increased urination, or an unusually fast or slow heartbeat.
Contact a poison control center or seek immediate medical care if you or someone else takes more than the prescribed amount.
Rise slowly from a sitting or lying position, especially when you first start treatment or after your dose is increased. This may help reduce dizziness or lightheadedness.
Contact your healthcare provider if you experience severe dizziness, fainting, very low blood pressure, ongoing vomiting or diarrhea, unusual weakness, muscle cramps, confusion, reduced urination, or an irregular heartbeat.
Avalide (Irbesartan/HCTZ) is available in the following forms and strength:
Do not take Avalide during pregnancy. Irbesartan affects the renin-angiotensin system and may cause serious harm or death to an unborn baby.
The risk is especially serious during the second and third trimesters. Avalide may reduce the baby’s kidney function and lead to low amniotic fluid, poor lung or bone development, kidney failure, or death.
Stop taking Avalide and contact your healthcare provider immediately if you become pregnant or think you may be pregnant.
Avalide may interact with many prescription medications, over-the-counter medicines, vitamins, and supplements. Some interactions may increase side effects, affect kidney function, alter electrolyte levels, or change how well Avalide works.
Tell your healthcare provider and pharmacist about every product you take. Do not start, stop, or change another medication without medical advice.
Hydrochlorothiazide may rarely cause sudden nearsightedness or a serious condition called angle-closure glaucoma. These problems may develop within hours or weeks after starting treatment.
Seek immediate medical attention if you experience:
People with a history of sulfonamide or penicillin allergy may have a higher risk of these reactions.
Avalide may reduce kidney function or worsen existing kidney disease. The risk may be higher in people with severe heart failure, dehydration, reduced blood flow to the kidneys, or previous kidney problems.
Your healthcare provider may order blood and urine tests before and during treatment to monitor kidney function.
Contact your healthcare provider if you notice:
Avalide may cause blood pressure to become too low. This may lead to dizziness, weakness, lightheadedness, or fainting.
The risk is higher in people who are dehydrated, receiving dialysis, taking high doses of diuretics, following a low-salt diet, or losing fluids through vomiting, diarrhea, or heavy sweating.
Tell your healthcare provider if you have experienced significant fluid or electrolyte loss. These problems may need to be corrected before treatment begins.
Stand up slowly from a sitting or lying position. Contact your healthcare provider if dizziness is severe or persistent, or if you faint.
Avalide may cause an allergic reaction. The risk may be higher in people with asthma or a previous allergy to hydrochlorothiazide, sulfonamide medications, or other drug ingredients.
Stop taking Avalide and seek emergency medical care if you develop:
Weight gain is not a common side effect of Avalide. However, sudden weight gain may be a sign of fluid retention or worsening heart or kidney problems. Contact your healthcare provider if you notice rapid weight gain, swelling in your feet or legs, or increased shortness of breath.
Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Yes. Avalide may be taken with or without food. Try to take it at the same time each day. Because it may increase urination, taking it in the morning may help reduce nighttime trips to the bathroom.
Avalide may be used long-term when prescribed and monitored by a healthcare provider. However, it may affect kidney function, blood pressure, blood sugar, and electrolyte levels such as sodium and potassium. Your healthcare provider may order regular blood tests and blood pressure checks to make sure the medication remains safe and effective.
Do not stop taking Avalide without speaking with your healthcare provider. Avalide controls high blood pressure but does not cure it. Stopping treatment may cause your blood pressure to rise again, even if you feel well. This may increase the risk of stroke, heart attack, kidney damage, and other complications.
| Generic name: | Ibesartan/HCTZ, Irbesartan/HCTZ, Irbesartan/Hctz |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 150/12.5mg, 300/12.5mg, 300/25mg |
| Quantities Available: | 84, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Avalide (irbesartan/HCTZ) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is standard for prescription medications to ensure effective management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Avalide is available in different strengths combining irbesartan and hydrochlorothiazide (e.g., 150/12.5 mg, 300/12.5 mg, 300/25 mg). For a 90-day supply, the quantity would depend on your prescribed dosage.
For instance, if prescribed Avalide 150/12.5 mg to be taken once daily, then fo a 90-day supply, you would order 90 tablets (90 days x 1 tablet per day).
Yes, we sell irbesartan/HCTZ on our website, and you can enjoy low prices on this medication. To purchase irbesartan/HCTZ from us, you will need a valid prescription from your healthcare provider. We require this to ensure safe and legal dispensing of the medication. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Avalide (irbesartan/HCTZ) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Avalide (Irbesartan/Hctz). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Avalide (Irbesartan/Hctz).
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