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Polytrim is a prescription medication that contains a combination of two antibiotics, polymyxin B and trimethoprim. It is used to treat bacterial infections of the eye such as conjunctivitis and blepharitis. Polytrim works by combining two antibiotics, polymyxin B and trimethoprim, to kill bacteria.

Polymyxin B works by interfering with the bacterial cell membrane, causing it to break down, while trimethoprim blocks the bacterial enzyme dihydrofolate reductase, which is necessary for the bacteria to produce folate. By interrupting these processes, the antibiotics can kill or prevent the growth of the bacteria causing the infection. When used correctly, Polytrim can be an effective treatment for bacterial infections of the eye.

Uses and Dosage

To ensure proper application of Polytrim eye drops, follow the instructions carefully. Before applying the drops, wash your hands thoroughly to avoid contamination. Do not wear contact lenses while using this medication. Tilt your head back, look upward, and pull down your lower eyelid to create a pouch. Place the dropper directly over your eye and squeeze one drop into the pouch according to your doctor's directions. Do not touch the dropper tip or let it touch your eye or any other surface. After applying the drop, close your eyes gently and place a finger on the corner of your eye near the nose, applying gentle pressure for 1 to 2 minutes to prevent the medication from draining out.

Avoid blinking or rubbing your eye. Repeat the process with the other eye, if directed. Wait a few minutes for your vision to clear before driving or operating machinery. Do not rinse the dropper and replace the dropper cap after each use. Follow your doctor's instructions regarding the dosage, frequency, and duration of the treatment. Do not swallow or inject the medication.

Side effect

Common Side Effects of Polytrim (Polymyxin/ Trimethoprim):

  • Eye irritation (redness, burning, stinging, or itching)
  • Eyelid swelling
  • Increased redness
  • Itching
  • Rash
  • Tearing of the eye

Serious Side Effects of Polytrim (Polymyxin/ Trimethoprim):

Form and Strength

Plendil is available in the following forms and strength:

Polytrim: Eye drops

  • No dose


  • Caution should be exercised when administering Polytrim ophthalmic solution to a nursing woman.
  • Polytrim ophthalmic solution may cause adverse effects, so it is best to consult a doctor for medical advice on minimizing side effects.
  • There are serious adverse events that could occur from using over-the-counter medication (available without a prescription) containing trimethoprim/polymyxin B in children. However, it is not clear if these risks also apply to Polytrim specifically.
  • Polytrim falls under pregnancy category C, which means that it should only be used with caution if the benefits outweigh the risks.
  • Patients should avoid wearing contact lenses while using Polytrim eye drops.
  • Polytrim should not be used to treat viral or fungal eye infections.
  • Patients should inform their doctor if they are taking any other medications, supplements, or have any other medical conditions before using Polytrim to avoid potential drug interactions.
  • Complete the full course of treatment, even if symptoms improve before the treatment is finished.

Frequently Asked Questions (FAQ)

How long does it take for Polytrim (polymyxin B / trimethoprim) to work?

Polytrim (polymyxin B / trimethoprim) starts working right away since it is placed right where the infection is. Your symptoms should start to improve in a couple of days, so let your provider know if things are not looking better after that.

How many days do you use polymyxin eye drops?

It is usually instilled once in the affected eye(s) every three hours (maximum of 6 doses in 24 hours) for 7 to 10 days. Use ophthalmic polymyxin B and trimethoprim at around the same time every day.

What is the stability of polymyxin?

Polymyxin B1 and B2 were stable for 24 hours in saline (0.9%) and glucose solution (5%), however a significant degradation of polymyxin B1 and B2 was observed after 48 hours and 72 hours of assay.


Additional information

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Polytrim (Polymixin/trimethoprim). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Polytrim (Polymixin/trimethoprim).