Paxil CR (Paroxetine)

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Paxil CR Brand
Dosage Quantity & Price
Paroxetine (Generic alternate to Paxil CR) Generic
Dosage Quantity & Price
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Table of contents:

Paxil CR is an antidepressant medication that is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), and other conditions.

Paxil CR contains the active ingredient paroxetine hydrochloride. It is classified as a selective serotonin reuptake inhibitor (SSRI). It works by increasing the levels of serotonin, a neurotransmitter in the brain that helps regulate mood.

Paroxetine can improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It can be used to lessen premenstrual symptoms such as irritability, increased appetite, and depression.

Use and Dosage

Paroxetine comes as a tablet to be taken orally, with or without food, as directed by your doctor, usually once daily in the morning. Swallow the tablets whole and do not crush or chew them, as doing so can increase the risk of side effects by releasing all the drugs at once.

The recommended dosage of Paroxetine varies depending on the individual's medical condition, age, and other medications that they may be taking. The maximum recommended dose of Paroxetine is typically 50-60 mg per day, depending on the reason for taking it. However, the starting dose of Paroxetine is often lower to reduce the risk of side effects. Additionally, the dosage may be adjusted gradually over time to manage symptoms effectively. Taking Paroxetine regularly can help you get the most benefit from it, so try to take it at the same time each day to remember.

If you are taking Paroxetine for premenstrual problems, your doctor may advise you to take it every day of the month or just for the two weeks before your period through the first full day of your period.

Do not stop taking Paroxetine suddenly without consulting your doctor, even if you feel better. Stopping the medication abruptly can make some conditions worse, and you may experience symptoms such as mood swings, headache, tiredness, sleep changes, or sudden feelings resembling electric shock. To avoid these symptoms, your doctor may gradually reduce your dose when stopping treatment with Paroxetine. If you experience any new or worsening symptoms, it is essential to report them right away.

Side Effects

Common Side Effects of Paxil CR (Paroxetine):

  • Constipation
  • Decreased appetite
  • Decreased sexual desire or ability
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Headache
  • Increased sweating
  • Menstrual period changes
  • Nausea
  • Nervousness
  • Nightmares
  • Sun sensitivity
  • Tremor
  • Trouble sleeping
  • Vomiting
  • Weakness
  • Weight gain
  • Yawning

Serious Side Effects of Paxil CR (Paroxetine):

  • Agitation
  • Bleeding gums
  • Blood in urine
  • Bloody nose
  • Breast discomfort
  • Breast swelling
  • Changes in behavior
  • Changes in sleep habits
  • Confusion
  • Coughing blood
  • Dark urine
  • Diarrhea
  • Difficulty concentrating
  • Dilated pupils
  • Drowsiness
  • Dryness of mouth
  • Feeling sad
  • Feelings of guilt or worthlessness
  • Feelings of paranoia
  • Hallucinations
  • Increased cholesterol levels
  • Increased thirst
  • Lack of energy
  • Losing interest in things you used to enjoy
  • Loss of appetite
  • Muscle pain or weakness
  • Nausea
  • Pale stools
  • Problems with urination
  • Restlessness
  • Seizures
  • Skin rash or hives
  • Swelling of the hands, ankles, or feet
  • Thoughts of suicide
  • Uncontrolled body or face movement
  • Vomiting
  • Weight changes
  • Weight loss
  • Yellowing of the skin or whites of the eyes

Forms and Strength

Paxil CR (Paroxetine) is available in the following forms and strength:

Paxil CR: ER Tablet

  • 12.5 mg
  • 25 mg

Paroxetine: ER Tablet

  • 12.5 mg
  • 25 mg
  • 37.5 mg


  • Suicidal Thoughts and Behavior: Paxil CR may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults who have a major depressive disorder or other psychiatric disorders. Patients who are taking the tablet should be monitored closely for changes in mood, behavior, or thinking.
  • Serotonin Syndrome: Paxil CR may cause a potentially life-threatening condition known as serotonin syndrome when used in combination with other drugs that increase serotonin levels. These drugs include other antidepressants, opioids, and triptans. Symptoms of serotonin syndrome may include agitation, hallucinations, fast heart rate, fever, sweating, muscle stiffness, tremors, and diarrhea.
  • Bleeding Risk: Paxil CR may increase the risk of bleeding, especially when used with other drugs that also increase bleeding risk, such as nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, and warfarin. Patients taking Paxil CR should be advised to report any signs of abnormal bleeding or bruising, including nosebleeds, bleeding gums, and blood in the urine or stool.
  • Pregnancy and Breastfeeding: Paxil CR should be used with caution in pregnant or breastfeeding women, as it may have harmful effects on the developing fetus or infant. Women who are pregnant or planning to become pregnant should discuss the risks and benefits of using Paxil CR with their doctor.
  • Mania/Hypomania: Paxil CR may induce a manic or hypomanic episode in patients with bipolar disorder. Patients should be carefully monitored for signs and symptoms of mania or hypomania.
  • Seizures: Paxil CR can lower the seizure threshold, which is the point at which seizures can occur. Patients with a history of epilepsy or a predisposition to seizures should use Paxil CR with caution.
  • Hyponatremia: Paxil CR may cause hyponatremia, a condition characterized by low levels of sodium in the blood. Symptoms of hyponatremia may include nausea, headache, confusion, seizures, and coma.
  • Withdrawal Symptoms: Paxil CR should be discontinued gradually to avoid withdrawal symptoms, which may include dizziness, insomnia, nausea, and irritability.
  • Drug Interactions: Paxil CR may interact with other medications, including monoamine oxidase inhibitors (MAOIs), thioridazine, and drugs that affect liver enzymes. Patients should inform their doctor of all medications they are taking before starting Paxil CR.

Frequently Asked Questions (FAQ)

Is Paxil CR addictive?

Paxil CR is not classified as an addictive medication, although some patients may experience withdrawal symptoms when they stop taking the medication.

How long does it take for Paxil CR to start working?

It may take several weeks for Paxil CR to start working and for patients to feel the full benefits of the medication.

Can Paxil CR be taken with other medications?

Paxil CR may interact with other medications, so patients should inform their doctor of all medications they are taking before starting Paxil CR.

Can Paxil CR be stopped suddenly?

Paxil CR should not be stopped suddenly as patients may experience withdrawal symptoms. Patients should consult their doctor before stopping the medication.


It's important to purchase Paxil CR from verified Canadian pharmacy.

Additional information

Generic name:

Paroxetine, Paroxetine CR


ER Tablet


12.5mg, 25mg, 37.5mg

Quantities Available:

30, 90