Otezla (Apremilast)

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Otezla Brand

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Apremilast (Generic alternate to Otezla) Generic
Dosage Quantity & Price
10mg
20mg
30mg
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Table of contents:

Otezla is an oral medication used for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. Its active ingredient is apremilast. Apremilast belongs to a class of drugs known as phosphodiesterase 4 (PDE4) inhibitors. It works inside inflammatory cells to reduce overactive Phosphodiesterase 4 (PDE4) activity. A reduction in PDE4 activity is thought to help reduce the overactive inflammation that happens in people with plaque psoriasis.

Uses and Dosage

Otezla comes in the form of tablet to take by mouth with or without food as directed by your doctor, usually twice daily. To reduce your risk of side effects, do not crush, split, or chew the tablet before taking it. The dosage is based on your medical condition and response to treatment.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

The recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6, after 5 days of an initial schedule of titration dosing.

Side effect

Common Side Effects of Otezla (Apremilast):

Serious Side Effects of Otezla (Apremilast):

  • Gastrointestinal problems, including:
    • Nausea
    • Vomiting
    • Diarrhea
    • Abdominal pain
    • Dyspepsia, also known as indigestion
    • Increased frequency and volume of bowel movements
  • Feelings of malaise, including:
    • Fatigue
    • Insomnia
    • Back pain
    • Arthralgias, also known as joint pain
  • Severe diarrhea or vomiting
  • Severe hypersensitivity or allergic reactions
  • Psychological disturbances and mood changes, including:
    • Depression
    • Suicidal ideation (thinking about or planning suicide)

Form and strength

Otezla (Apremilast) is available in the following forms and strength:

Apremilast: Tablet

  • 10 mg
  • 30 mg

Caution

  • In elderly patients Otezla can increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.
  • Before taking apremilast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. It may contain inactive ingredients, which can cause allergic reactions or other problems.
  • Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.
  • Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat, or arms.
  • Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.
  • Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Frequently Asked Questions (FAQ)

Can Otezla be used to treat psoriatic arthritis?

Yes, Otezla is approved for the treatment of psoriatic arthritis.

How long does it take for Otezla to start working?

It may take a few weeks or months to see the full effects of Otezla. Your doctor may direct you to start with a low dose and gradually increase the dose to minimize the risk of side effects.

Can I drink alcohol while taking Otezla?

Avoid alcohol while taking Otezla, as it may increase the risk of side effects such as dizziness.

Can I take Otezla if I am pregnant or breastfeeding?

Take Otezla if you are pregnant or breastfeeding, as the effects on the fetus or infant are not known. Make sure to discuss any concerns with your doctor.

Resources

It's important to purchase Otezla from verified Canadian pharmacy.

Additional information

Generic name:

Apremilast

Formulation:

Tablet

Strength(s):

10mg, 20mg, 30mg

Quantities Available:

60, 90

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