Otezla (Apremilast) Shopper Approved

Prescription Prescription Required FormationFormulation: Tablet


We don't sell this brand-version medication.

Prescription Prescription Required FormationFormulation: Tablet


(Generic Alternative)

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Otezla (active ingredient: apremilast) is a prescription medication indicated for:

  1. Treatment of Psoriatic Arthritis: Otezla is indicated for the treatment of adult patients with active psoriatic arthritis.
  2. Treatment of Moderate to Severe Plaque Psoriasis: Otezla is also indicated for the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.

Otezla belongs to the drug class known as phosphodiesterase 4 (PDE4) inhibitors, which work by modulating the immune response to reduce inflammation associated with psoriatic arthritis and plaque psoriasis.

Uses and Dosage

Otezla comes in the form of tablet to take by mouth with or without food as directed by your doctor, usually twice daily. To reduce your risk of side effects, do not crush, split, or chew the tablet before taking it. The dosage is based on your medical condition and response to treatment.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

The recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6, after 5 days of an initial schedule of titration dosing.

Side Effect

Common Side Effects of Otezla (Apremilast):

Serious Side Effects of Otezla (Apremilast):

  • Gastrointestinal problems, including:
    • Nausea
    • Vomiting
    • Diarrhea
    • Abdominal pain
    • Dyspepsia, also known as indigestion
    • Increased frequency and volume of bowel movements
  • Feelings of malaise, including:
    • Fatigue
    • Insomnia
    • Back pain
    • Arthralgias, also known as joint pain
  • Severe diarrhea or vomiting
  • Severe hypersensitivity or allergic reactions
  • Psychological disturbances and mood changes, including:
    • Depression
    • Suicidal ideation (thinking about or planning suicide)

Form and Strength

Otezla (Apremilast) is available in the following forms and strength:

Apremilast: Tablet

  • 10 mg
  • 20 mg
  • 30 mg


  • In elderly patients Otezla can increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.
  • Before taking apremilast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. It may contain inactive ingredients, which can cause allergic reactions or other problems.
  • Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.
  • Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat, or arms.
  • Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.
  • Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Frequently Asked Questions (FAQ)

Can Otezla be used to treat psoriatic arthritis?

Yes, Otezla is approved for the treatment of psoriatic arthritis.

How long does it take for Otezla to start working?

It may take a few weeks or months to see the full effects of Otezla. Your doctor may direct you to start with a low dose and gradually increase the dose to minimize the risk of side effects.

Can I drink alcohol while taking Otezla?

Avoid alcohol while taking Otezla, as it may increase the risk of side effects such as dizziness.

Can I take Otezla if I am pregnant or breastfeeding?

Take Otezla if you are pregnant or breastfeeding, as the effects on the fetus or infant are not known. Make sure to discuss any concerns with your doctor.


Additional information

Generic name:





10mg, 20mg, 30mg

Quantities Available:

60, 180


Additional Information Book

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Kelsey Stalvey Medically reviewed by
Kelsey Stalvey, PharmD

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How to Order

How much Otezla can I order at once from a Canadian pharmacy?

When ordering Otezla (apremilast) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Otezla is commonly prescribed in dosages of 10 mg, 20 mg, or 30 mg taken orally twice daily. For a 90-day supply, you would order 180 tablets (90 days x 2 tablets per day).

Do you sell apremilast?

Yes, we sell apremilast. You can enjoy low prices on this medication when you order from us. You will need a valid prescription from your healthcare provider to purchase apremilast. We require this to dispense the medication. You can mail, fax, or upload your prescription through your online account.

Do you offer shipping of Otezla (apremilast) to the United States?

Yes, we ship Otezla (apremilast) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Otezla (Apremilast). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Otezla (Apremilast).