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Prescription Prescription Required FormationFormulation: Tablet


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Prescription Prescription Required FormationFormulation: Tablet

Alogliptin Benzoate

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Nesina is a prescription medication used along with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. It contains the active ingredient Alogliptin Benzoate. Alogliptin belongs to the group of diabetes medications called DPP-4 inhibitors. Alogliptin works by preventing the breakdown of incretin. Incretin is a hormone that raises insulin levels when blood sugar is high and decreases the amount of sugar made by the body.

Alogliptin is used alone or in combination with other medications to improve blood sugar levels for adults with type 2 diabetes. Nesina should be used as part of an overall diabetes management plan that includes a diet and exercise program.

Uses and Dosage

To help manage type 2 diabetes, Nesina is taken in tablet form by mouth once a day, as prescribed by a healthcare provider, with or without food. The tablet should be swallowed whole and not chewed or crushed.

Take the tablet on a regular basis to obtain the maximum benefit. To help remember to take Nesina, it is recommended to take it at the same time every day. Follow the diabetes management plan carefully, which includes diet, exercise, and medication. Check your blood sugar levels regularly, as instructed by the healthcare provider, and note the results. If blood sugar measurements are often outside of the normal range, inform your healthcare provider. They may require adjusting your diabetes medication, exercise regime, or diet.

For adults, the suggested amount of Nesina is 25 mg taken once daily, and it can be taken either with or without food, but it should be consumed at the same time every day, roughly.

Side Effects

Common Side Effects of Nesina (Alogliptin Benzoate):

  • Abdominal pain
  • Back, bone, joint, or muscle pain
  • Cold or flu-like symptoms (e.g., sore throat, cough, stuffy nose, fever, fatigue)
  • Constipation
  • Headache
  • Heartburn
  • Itchy skin
  • Muscle spasms
  • Nausea
  • Rash
  • Tiredness
  • Trouble sleeping
  • Vomiting

Serious Side Effects of Nesina (Alogliptin Benzoate):

  • High cholesterol
  • Increased blood pressure
  • Pain or numbness in the extremities
  • Red, peeling, or blistering skin
  • Severe joint pain
  • Signs of anemia (low red blood cells, e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • Signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • Signs of muscle damage (e.g., unexplained muscle pain, tenderness, or weakness, or brown or discolored urine)
  • Signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • Stomach or abdominal pain
  • Swelling of the hands, feet, ankles
  • Symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)

Form and Strength

Nesina (Alogliptin Benzoate) is available in the following forms and strengths:

Nesina: Tablet

  • 6.25 mg
  • 12.5 mg
  • 25 mg


  • Nesina may cause hypoglycemia (low blood sugar), especially if taken in conjunction with insulin or other medications that lower blood sugar levels. Symptoms of hypoglycemia include shakiness, headaches, sweating, confusion, irritability, difficulty concentrating, and rapid heartbeat.
  • Cases of pancreatitis, a potentially serious inflammation of the pancreas, have been reported in patients taking Nesina. Symptoms of pancreatitis include severe abdominal pain, nausea, vomiting, and fever.
  • Nesina has been associated with an increased risk of heart failure, especially in patients with pre-existing heart disease or other cardiovascular risk factors. Symptoms of heart failure include shortness of breath, swelling of the legs and feet, fatigue, and rapid or irregular heartbeat.
  • Some patients may experience allergic reactions to Nesina with symptoms including rash, itching, swelling of the face, tongue, or throat, and difficulty breathing.
  • Nesina may cause an increase in liver enzymes, which may indicate liver problems. Patients should be monitored for signs of liver dysfunction such as abdominal pain, jaundice, or dark urine.
  • Nesina is primarily excreted through the kidneys, and patients with renal impairment may be at increased risk for adverse reactions. Dosing adjustments may be necessary in patients with moderate to severe renal impairment.
  • Rare cases of hypersensitivity reactions, including anaphylaxis, angioedema, and severe cutaneous adverse reactions, have been reported in patients taking Nesina.
  • The safety and efficacy of Nesina have not been established in elderly patients (age 65 or older), and caution should be used when prescribing this medication to older adults.
  • Nesina should be used with caution in patients with mild to moderate hepatic impairment, as it has not been studied in these populations.
  • Nesina may interact with other medications, such as CYP3A4 inhibitors and inducers, which can affect the metabolism of Nesina and alter its effectiveness or safety.

Frequently Asked Questions (FAQ)

Can Nesina change my weight?

While some blood sugar medications can affect your weight, Nesina doesn’t cause notable weight loss or weight gain. It is meant to be taken with a healthy diet and regular exercise to help lower your blood sugar.

When is the best time to take alogliptin?

Take alogliptin once a day. You can take it at any time, for example, in the morning or in the evening. But try to take it at the same time every day. Take your tablet with a drink of water.

Can alogliptin be taken for long time?

Alogliptin is safe to take for a long time. There do not seem to be any lasting harmful effects from taking it for many months or even years.


Additional information

Generic name:

Alogliptin Benzoate




6.25mg, 12.5mg, 25mg

Quantities Available:

28, 84


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Nesina (Alogliptin Benzoate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Nesina (Alogliptin Benzoate).