Motilium DT (Domperidone)

Indications

Motilium DT is a prescription oral medication which is used as an anti-emetic medicine for the treatment of nausea and vomiting caused by slow-moving stomach resulting in delayed emptying. It can be known for its effect on increasing breast milk production by raising levels of prolactin.

Motilium contains Domperidone as an active ingredient. Domperidone is an antiemetic (anti-sickness) and prokinetic drug. It works by blocking certain receptors such as dopamine and serotonin that trigger these symptoms.

Use and Dosage

Domperidone comes as a tablet that should be taken with a glass of water before meals, and the dose and duration of treatment should be determined by a healthcare professional. The tablets should be swallowed whole with a drink of water and not crushed or chewed.

The recommended dosages of Domperidone tablets vary slightly depending on the source, but the usual dose is 10mg tablet taken up to three times per day, preferably before meals. The maximum daily dose is typically 30mg per day. However, the dosage and duration of treatment should be determined by a healthcare professional and may be adjusted depending on the individual's medical condition and response to the medication.

If you miss a dose of Motilium DT (Domperidone), take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Side Effects

Common Side Effects of Motilium DT (Domperidone):

• A blood test shows changes in the way your liver is working
• Abnormal eye movements
• Breast enlargement in men
• Feeling agitated or irritable
• Feeling more nervous than usual
• In women, menstrual cycles may become irregular or stop
• Inability to urinate

Serious Side Effects of Motilium DT (Domperidone):

• Diarrhea
• Feeling anxious
• Feeling drowsy
• Headaches
• Irregular eye movements
• Itchy skin
• Lowering of sexual drive (libido) in men
• Muscle stiffness
• Painful or tender breasts
• Seizure
• Trembling
• Unusual movements of the tongue, and abnormal posture such as a twisted neck
• Unusual production of breast milk in men and women
• Very fast or unusual heartbeat
• You get swelling of the hands, feet, ankles, face, lips, or throat which may cause difficulty in swallowing or breathing
• You may also notice an itchy, lumpy rash (hives) or nettle rash (urticaria)
• A general feeling of weakness

Forms and Strength

Motilium DT (Domperidone) is available in the following forms and strength:

Domperidone: Dispersible Tablet

• 5 mg

Cautions

• Domperidone should only be used under medical supervision and after considering the risks versus benefits, especially in patients with pre-existing cardiac conditions.
• Domperidone may cause side effects such as dry mouth, headache, dizziness, abdominal cramps, diarrhea, and skin rash.
• The use of domperidone may also occasionally lead to serious side effects such as abnormal heartbeat, seizure, or allergic reactions, and it should be discontinued immediately if any of these occur.
• In some rare cases, domperidone has been linked to a serious condition affecting the heart rhythm, especially when taken in high doses or in combination with certain medications.
• Domperidone should not be used in patients with known intolerance or allergy to domperidone or any of its ingredients.
• Domperidone can pass into breastmilk and may not be suitable for use in breastfeeding mothers. The decision to use it in such cases should be made in consultation with a healthcare professional.
• Domperidone is contraindicated in patients with pituitary gland tumors.
• Patients with liver or kidney problems should use domperidone with caution and under medical supervision due to the potential for decreased clearance of the drug from the body.
• Domperidone may interact with certain medications such as antifungal drugs, antibiotics, and medications that affect heart rhythm, which may increase the risk of side effects or drug interactions.
• Domperidone should not be used in patients who are taking medications that may prolong the QT interval (a measure of the electrical signal in the heart), such as some antidepressants or antipsychotics.
• Domperidone is not recommended for use in children under 12 years of age, as there is limited data available on its safety and effectiveness in this population.
• In some countries, including the United States, domperidone is not approved for use due to concerns about its safety.

Frequently Asked Questions (FAQ)

Is it safe to use domperidone?

The safety of using domperidone should be assessed by considering its risks versus benefits and taking caution in patients with pre-existing cardiac conditions, liver or kidney problems, or other medications that may prolong the QT interval.

Is domperidone effective for reducing gastro-oesophageal reflux (GOR)?

The efficacy of domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) is still being studied, and there is limited evidence available to support its use.

Can domperidone increase breast milk production?

Yes, domperidone is known to increase breast milk production by raising levels of prolactin in the body.

Is domperidone safe for use in children?

The safety of using domperidone in children under 12 years of age is still being studied, and caution should be exercised in this population.

Resources

• https://www.apollopharmacy.in/medicine/motilium-m-tablet
• https://www.netmeds.com/prescriptions/motinorm-dt-10mg-tablet-10-s
• https://www.1mg.com/drugs/motinorm-dt-10mg-tablet-227611
• https://www.drugs.com/domperidone.html
• https://thewomens.r.worldssl.net/images/uploads/fact-sheets/Domperidone-for-increasing-breast-milk-supply-260219.pdf